| Oct 10, 1981 | Arizona 13, 1USC 10upset | Box score |
| Oct 10, 1981 | Arizona State 24, Oregon 0 | Box score |
| Oct 10, 1981 | Arkansas 26, Texas Tech 14 | Box score |
| Oct 10, 1981 | Arkansas State 14, Louisiana 3 | Box score |
| Oct 10, 1981 | Auburn 19, LSU 7 | Box score |
| Oct 10, 1981 | Brown 26, Pennsylvania 24 | Box score |
| Oct 10, 1981 | Cal State Fullerton 13, Fresno State 10 | Box score |
| Oct 10, 1981 | Central Michigan 15, Western Michigan 13 | Box score |
| Oct 10, 1981 | Chattanooga 20, Marshall 0 | Box score |
| Oct 10, 1981 | Cincinnati 19, Ohio 9upset | Box score |
| Oct 10, 1981 | 9Clemson 27, Virginia 0 | Box score |
| Oct 10, 1981 | Drake 24, Wichita State 23 | Box score |
| Oct 10, 1981 | Duke 14, Virginia Tech 7 | Box score |
| Oct 10, 1981 | East Carolina 17, Richmond 13 | Box score |
| Oct 10, 1981 | Florida 15, Maryland 10 | Box score |
| Oct 10, 1981 | 20Florida State 19, Notre Dame 13 | Box score |
| Oct 10, 1981 | Furman 22, App State 18 | Box score |
| Oct 10, 1981 | 11Georgia 37, Ole Miss 7 | Box score |
| Oct 10, 1981 | Harvard 27, Cornell 10 | Box score |
| Oct 10, 1981 | Hawai’i 14, Wyoming 9 | Box score |
| Oct 10, 1981 | Indiana State 31, Ball State 7 | Box score |
| Oct 10, 1981 | 15Iowa 42, Indiana 28 | Box score |
| Oct 10, 1981 | Kent State 31, Northern Illinois 10 | Box score |
| Oct 10, 1981 | Lamar 17, UL Monroe 13upset | Box score |
| Oct 10, 1981 | Louisville 14, Memphis 7 | Box score |
| Oct 10, 1981 | Bowling Green 7, Miami (OH) 7 | Box score |
| Oct 10, 1981 | 6Michigan 38, Michigan State 20 | Box score |
| Oct 10, 1981 | Minnesota 35, Northwestern 23 | Box score |
| Oct 10, 1981 | 19Mississippi State 37, Colorado State 27 | Box score |
| Oct 10, 1981 | 13Missouri 58, Kansas State 13 | Box score |
| Oct 10, 1981 | Navy 30, Air Force 13 | Box score |
| Oct 10, 1981 | Nebraska 59, Colorado 0 | Box score |
| Oct 10, 1981 | UNLV 45, 8BYU 41upset | Box score |
| Oct 10, 1981 | New Mexico 26, UTEP 3 | Box score |
| Oct 10, 1981 | 5North Carolina 48, Wake Forest 10 | Box score |
| Oct 10, 1981 | North Texas 38, New Mexico State 16 | Box score |
| Oct 10, 1981 | Oklahoma State 20, Kansas 7 | Box score |
| Oct 10, 1981 | 2Penn State 38, Boston College 7 | Box score |
| Oct 10, 1981 | 4Pittsburgh 17, West Virginia 0 | Box score |
| Oct 10, 1981 | Princeton 21, Columbia 14 | Box score |
| Oct 10, 1981 | Purdue 44, Illinois 20 | Box score |
| Oct 10, 1981 | Rice 41, TCU 28 | Box score |
| Oct 10, 1981 | Rutgers 17, Army 0 | Box score |
| Oct 10, 1981 | San Diego State 52, 12Iowa State 31upset | Box score |
| Oct 10, 1981 | South Carolina 28, Kentucky 14 | Box score |
| Oct 10, 1981 | Southern Illinois 29, West Texas 22upset | Box score |
| Oct 10, 1981 | 14SMU 37, Baylor 20 | Box score |
| Oct 10, 1981 | Southern Miss 13, 7Alabama 13 | Box score |
| Oct 10, 1981 | Stanford 26, 17UCLA 23upset | Box score |
| Oct 10, 1981 | Temple 31, Colgate 0 | Box score |
| Oct 10, 1981 | Tennessee 10, Georgia Tech 7 | Box score |
| Oct 10, 1981 | 3Texas 34, 10Oklahoma 14 | Box score |
| Oct 10, 1981 | Texas A&M 7, Houston 6 | Box score |
| Oct 10, 1981 | Texas–Arlington 31, Louisiana Tech 14 | Box score |
| Oct 10, 1981 | Toledo 42, Eastern Michigan 7 | Box score |
| Oct 10, 1981 | Tulane 14, Vanderbilt 10 | Box score |
| Oct 10, 1981 | Utah State 17, Pacific 14 | Box score |
| Oct 10, 1981 | VMI 14, The Citadel 0 | Box score |
| Oct 10, 1981 | Washington 27, California 26 | Box score |
| Oct 10, 1981 | Washington State 23, Oregon State 0 | Box score |
| Oct 10, 1981 | William & Mary 12, Dartmouth 7upset | Box score |
| Oct 10, 1981 | Wisconsin 24, 18Ohio State 21upset | Box score |
| Oct 10, 1981 | Yale 29, Holy Cross 28 | Box score |