| Sep 20, 1980 | 1Alabama 59, Ole Miss 35 | Box score |
| Sep 20, 1980 | Arizona State 42, Oregon State 14 | Box score |
| Sep 20, 1980 | 17Arkansas 33, Oklahoma State 20 | Box score |
| Sep 20, 1980 | Army 26, California 19 | Box score |
| Sep 20, 1980 | 19Auburn 35, Duke 28 | Box score |
| Sep 20, 1980 | Ball State 27, Toledo 7 | Box score |
| Sep 20, 1980 | Baylor 43, West Texas 15 | Box score |
| Sep 20, 1980 | Boston College 30, 11Stanford 13upset | Box score |
| Sep 20, 1980 | BYU 28, Wisconsin 3 | Box score |
| Sep 20, 1980 | Central Michigan 16, Illinois State 0 | Box score |
| Sep 20, 1980 | Chattanooga 14, App State 7 | Box score |
| Sep 20, 1980 | Colorado State 15, Arizona 13upset | Box score |
| Sep 20, 1980 | Cornell 17, Princeton 7 | Box score |
| Sep 20, 1980 | Dartmouth 40, Pennsylvania 7 | Box score |
| Sep 20, 1980 | Drake 38, Lamar 7upset | Box score |
| Sep 20, 1980 | Florida 45, Georgia Tech 12 | Box score |
| Sep 20, 1980 | 9Florida State 63, East Carolina 7 | Box score |
| Sep 20, 1980 | Fresno State 16, Louisiana 14 | Box score |
| Sep 20, 1980 | Furman 28, Western Carolina 14 | Box score |
| Sep 20, 1980 | 10Georgia 20, Clemson 16 | Box score |
| Sep 20, 1980 | Harvard 26, Columbia 6 | Box score |
| Sep 20, 1980 | Hawai’i 25, Pacific 14 | Box score |
| Sep 20, 1980 | Indiana 36, Kentucky 30 | Box score |
| Sep 20, 1980 | Iowa State 27, San José State 6 | Box score |
| Sep 20, 1980 | Long Beach State 23, Bowling Green 21 | Box score |
| Sep 20, 1980 | LSU 23, Colorado 20 | Box score |
| Sep 20, 1980 | UL Monroe 35, Arkansas State 12upset | Box score |
| Sep 20, 1980 | Maryland 14, West Virginia 11 | Box score |
| Sep 20, 1980 | Miami 14, 18Houston 7upset | Box score |
| Sep 20, 1980 | Mississippi State 24, Vanderbilt 14 | Box score |
| Sep 20, 1980 | 15Missouri 52, Illinois 7 | Box score |
| Sep 20, 1980 | Navy 31, Kent State 3 | Box score |
| Sep 20, 1980 | 6Nebraska 57, Iowa 0 | Box score |
| Sep 20, 1980 | New Mexico State 18, Southern Illinois 17 | Box score |
| Sep 20, 1980 | NC State 27, Virginia 13 | Box score |
| Sep 20, 1980 | North Texas 35, UTEP 15 | Box score |
| Sep 20, 1980 | 8Notre Dame 29, 14Michigan 27 | Box score |
| Sep 20, 1980 | Ohio 34, Eastern Michigan 6 | Box score |
| Sep 20, 1980 | 2Ohio State 47, Minnesota 0 | Box score |
| Sep 20, 1980 | Oregon 35, Michigan State 7 | Box score |
| Sep 20, 1980 | 12Penn State 25, Texas A&M 9 | Box score |
| Sep 20, 1980 | 5Pittsburgh 18, Kansas 3 | Box score |
| Sep 20, 1980 | Rutgers 24, Cincinnati 7 | Box score |
| Sep 20, 1980 | San Diego State 13, Air Force 10 | Box score |
| Sep 20, 1980 | 4USC 23, 20South Carolina 13 | Box score |
| Sep 20, 1980 | SMU 17, TCU 14 | Box score |
| Sep 20, 1980 | Southern Miss 38, Louisiana Tech 11 | Box score |
| Sep 20, 1980 | Syracuse 36, Miami (OH) 24 | Box score |
| Sep 20, 1980 | Tennessee 35, Washington State 23 | Box score |
| Sep 20, 1980 | 7Texas 35, Utah State 17 | Box score |
| Sep 20, 1980 | Texas Tech 28, New Mexico 17 | Box score |
| Sep 20, 1980 | Tulane 35, Rice 14 | Box score |
| Sep 20, 1980 | UCLA 23, Purdue 14 | Box score |
| Sep 20, 1980 | Utah 45, UNLV 29 | Box score |
| Sep 20, 1980 | VMI 17, Marshall 3 | Box score |
| Sep 20, 1980 | Virginia Tech 7, William & Mary 3 | Box score |
| Sep 20, 1980 | Wake Forest 24, The Citadel 7 | Box score |
| Sep 20, 1980 | 16Washington 45, Northwestern 7 | Box score |
| Sep 20, 1980 | Western Michigan 35, Northern Illinois 6 | Box score |
| Sep 20, 1980 | Wichita State 23, Tulsa 10upset | Box score |
| Sep 20, 1980 | Wyoming 35, Richmond 14 | Box score |
| Sep 20, 1980 | Yale 45, Brown 17 | Box score |