| Sep 27, 1980 | Illinois 20, Air Force 20 | Box score |
| Sep 27, 1980 | 1Alabama 41, Vanderbilt 0 | Box score |
| Sep 27, 1980 | Arizona 31, California 24 | Box score |
| Sep 27, 1980 | 15Arkansas 13, Tulsa 10 | Box score |
| Sep 27, 1980 | Baylor 11, Texas Tech 3 | Box score |
| Sep 27, 1980 | BYU 41, Long Beach State 25 | Box score |
| Sep 27, 1980 | Central Michigan 21, Kent State 6 | Box score |
| Sep 27, 1980 | The Citadel 29, Chattanooga 13 | Box score |
| Sep 27, 1980 | Clemson 17, Western Carolina 10 | Box score |
| Sep 27, 1980 | Colgate 38, Cornell 20 | Box score |
| Sep 27, 1980 | Florida 21, Mississippi State 15 | Box score |
| Sep 27, 1980 | Furman 21, VMI 16 | Box score |
| Sep 27, 1980 | 10Georgia 34, TCU 3 | Box score |
| Sep 27, 1980 | Georgia Tech 17, Memphis 8 | Box score |
| Sep 27, 1980 | Harvard 14, Holy Cross 13 | Box score |
| Sep 27, 1980 | Houston 24, North Texas 17 | Box score |
| Sep 27, 1980 | Indiana 49, Colorado 7 | Box score |
| Sep 27, 1980 | Iowa State 10, Iowa 7 | Box score |
| Sep 27, 1980 | Kansas State 31, Arkansas State 7 | Box score |
| Sep 27, 1980 | Kentucky 21, Bowling Green 20 | Box score |
| Sep 27, 1980 | UL Monroe 24, Louisiana 0 | Box score |
| Sep 27, 1980 | Louisville 17, Kansas 9 | Box score |
| Sep 27, 1980 | Miami 10, 9Florida State 9upset | Box score |
| Sep 27, 1980 | Miami (OH) 42, Ball State 9 | Box score |
| Sep 27, 1980 | Michigan State 33, Western Michigan 7 | Box score |
| Sep 27, 1980 | 12Missouri 31, San Diego State 7 | Box score |
| Sep 27, 1980 | Navy 45, William & Mary 6 | Box score |
| Sep 27, 1980 | 3Nebraska 21, 11Penn State 7 | Box score |
| Sep 27, 1980 | UNLV 56, Colorado State 15 | Box score |
| Sep 27, 1980 | New Mexico 52, New Mexico State 19 | Box score |
| Sep 27, 1980 | 14North Carolina 17, 19Maryland 3 | Box score |
| Sep 27, 1980 | Northern Illinois 22, Ohio 21 | Box score |
| Sep 27, 1980 | 2Ohio State 38, 20Arizona State 21 | Box score |
| Sep 27, 1980 | Oregon 34, 13Washington 10upset | Box score |
| Sep 27, 1980 | Pacific 28, UTEP 14 | Box score |
| Sep 27, 1980 | 6Pittsburgh 36, Temple 2 | Box score |
| Sep 27, 1980 | Rice 17, LSU 7upset | Box score |
| Sep 27, 1980 | Rutgers 44, Princeton 13 | Box score |
| Sep 27, 1980 | South Carolina 17, 17Michigan 14upset | Box score |
| Sep 27, 1980 | 5USC 24, Minnesota 7 | Box score |
| Sep 27, 1980 | Southern Illinois 34, Drake 28 | Box score |
| Sep 27, 1980 | SMU 52, Texas–Arlington 16 | Box score |
| Sep 27, 1980 | Southern Miss 35, East Carolina 7 | Box score |
| Sep 27, 1980 | Stanford 31, 4Oklahoma 14upset | Box score |
| Sep 27, 1980 | Syracuse 42, Northwestern 21 | Box score |
| Sep 27, 1980 | Tennessee 42, 18Auburn 0upset | Box score |
| Sep 27, 1980 | 7Texas 35, Oregon State 0 | Box score |
| Sep 27, 1980 | Toledo 49, Eastern Michigan 7 | Box score |
| Sep 27, 1980 | Tulane 26, Ole Miss 24 | Box score |
| Sep 27, 1980 | 16UCLA 35, Wisconsin 0 | Box score |
| Sep 27, 1980 | Utah 27, Fresno State 12 | Box score |
| Sep 27, 1980 | Villanova 20, Boston College 9 | Box score |
| Sep 27, 1980 | Virginia 20, Duke 17 | Box score |
| Sep 27, 1980 | Wake Forest 27, NC State 7upset | Box score |
| Sep 27, 1980 | Washington State 31, Army 18 | Box score |
| Sep 27, 1980 | West Virginia 31, Richmond 28 | Box score |
| Sep 27, 1980 | Wichita State 13, Cincinnati 8 | Box score |
| Sep 27, 1980 | Wyoming 45, Hawai’i 20 | Box score |