| Sep 13, 1980 | App State 17, The Citadel 14 | Box score |
| Sep 13, 1980 | Arizona State 29, 9Houston 13upset | Box score |
| Sep 13, 1980 | Army 28, Holy Cross 7 | Box score |
| Sep 13, 1980 | 18Auburn 10, TCU 7 | Box score |
| Sep 13, 1980 | Ball State 18, Northern Illinois 17 | Box score |
| Sep 13, 1980 | Baylor 42, Lamar 7 | Box score |
| Sep 13, 1980 | BYU 35, San Diego State 11 | Box score |
| Sep 13, 1980 | Central Michigan 15, Miami (OH) 14 | Box score |
| Sep 13, 1980 | Clemson 19, Rice 3 | Box score |
| Sep 13, 1980 | Eastern Michigan 18, Bowling Green 16upset | Box score |
| Sep 13, 1980 | Florida 41, California 13upset | Box score |
| Sep 13, 1980 | 10Florida State 52, Louisville 0 | Box score |
| Sep 13, 1980 | 12Georgia 42, Texas A&M 0 | Box score |
| Sep 13, 1980 | Illinois 20, Michigan State 17 | Box score |
| Sep 13, 1980 | Iowa 16, Indiana 7 | Box score |
| Sep 13, 1980 | Iowa State 42, UL Monroe 7 | Box score |
| Sep 13, 1980 | Oregon 7, Kansas 7 | Box score |
| Sep 13, 1980 | Louisiana 27, East Carolina 21upset | Box score |
| Sep 13, 1980 | LSU 21, Kansas State 0 | Box score |
| Sep 13, 1980 | Marshall 17, Kent State 7 | Box score |
| Sep 13, 1980 | Maryland 31, Vanderbilt 6 | Box score |
| Sep 13, 1980 | McNeese 20, Toledo 17 | Box score |
| Sep 13, 1980 | 11Michigan 17, Northwestern 10 | Box score |
| Sep 13, 1980 | Minnesota 38, Ohio 14 | Box score |
| Sep 13, 1980 | Ole Miss 61, Memphis 7 | Box score |
| Sep 13, 1980 | Mississippi State 31, Louisiana Tech 11 | Box score |
| Sep 13, 1980 | 17Missouri 47, New Mexico 16 | Box score |
| Sep 13, 1980 | 8Nebraska 55, Utah 9 | Box score |
| Sep 13, 1980 | UNLV 35, Fresno State 6 | Box score |
| Sep 13, 1980 | New Mexico State 6, UTEP 3 | Box score |
| Sep 13, 1980 | 15North Carolina 9, Texas Tech 3 | Box score |
| Sep 13, 1980 | 1Ohio State 31, Syracuse 21 | Box score |
| Sep 13, 1980 | 4Oklahoma 29, Kentucky 7 | Box score |
| Sep 13, 1980 | 3Pittsburgh 14, Boston College 6 | Box score |
| Sep 13, 1980 | 20Purdue 12, Wisconsin 6 | Box score |
| Sep 13, 1980 | Richmond 21, Villanova 7upset | Box score |
| Sep 13, 1980 | Rutgers 21, Temple 3upset | Box score |
| Sep 13, 1980 | San José State 31, Washington State 26 | Box score |
| Sep 13, 1980 | South Carolina 73, Wichita State 0 | Box score |
| Sep 13, 1980 | 5USC 20, Tennessee 17 | Box score |
| Sep 13, 1980 | SMU 28, North Texas 9 | Box score |
| Sep 13, 1980 | 13Stanford 19, Tulane 14 | Box score |
| Sep 13, 1980 | Tulsa 31, Cincinnati 13 | Box score |
| Sep 13, 1980 | UCLA 56, Colorado 14 | Box score |
| Sep 13, 1980 | Virginia 6, Navy 3 | Box score |
| Sep 13, 1980 | VMI 13, William & Mary 10 | Box score |
| Sep 13, 1980 | 19Washington 50, Air Force 7 | Box score |
| Sep 13, 1980 | West Texas 20, Oklahoma State 19 | Box score |
| Sep 13, 1980 | West Virginia 52, Colorado State 24 | Box score |
| Sep 13, 1980 | Western Michigan 31, Illinois State 17 | Box score |
| Sep 13, 1980 | Wyoming 30, Oregon State 10 | Box score |