| Sep 5, 1980 | Northern Illinois 16, Long Beach State 9 | Box score |
| Sep 6, 1980 | 2Alabama 26, Georgia Tech 3 | Box score |
| Sep 6, 1980 | Cal State Fullerton 39, Fresno State 25 | Box score |
| Sep 6, 1980 | Central Michigan 21, Ball State 17 | Box score |
| Sep 6, 1980 | Colorado State 21, Air Force 9 | Box score |
| Sep 6, 1980 | East Carolina 35, Duke 10 | Box score |
| Sep 6, 1980 | 13Florida State 16, LSU 0 | Box score |
| Sep 6, 1980 | 16Georgia 16, Tennessee 15 | Box score |
| Sep 6, 1980 | Illinois 35, Northwestern 9 | Box score |
| Sep 6, 1980 | Indiana State 13, Drake 10 | Box score |
| Sep 6, 1980 | Kentucky 17, Utah State 10 | Box score |
| Sep 6, 1980 | Louisiana 14, New Mexico State 12 | Box score |
| Sep 6, 1980 | Maryland 7, Villanova 3 | Box score |
| Sep 6, 1980 | McNeese 20, West Texas 17 | Box score |
| Sep 6, 1980 | Miami 24, Louisville 10 | Box score |
| Sep 6, 1980 | Mississippi State 34, Memphis 7 | Box score |
| Sep 6, 1980 | New Mexico 25, BYU 21upset | Box score |
| Sep 6, 1980 | 14North Carolina 35, Furman 13 | Box score |
| Sep 6, 1980 | NC State 42, William & Mary 0 | Box score |
| Sep 6, 1980 | North Texas 31, Texas–Arlington 14upset | Box score |
| Sep 6, 1980 | 11Notre Dame 31, 9Purdue 10upset | Box score |
| Sep 6, 1980 | 18Penn State 54, Colgate 10 | Box score |
| Sep 6, 1980 | Richmond 20, Bowling Green 17 | Box score |
| Sep 6, 1980 | South Carolina 37, Pacific 0 | Box score |
| Sep 6, 1980 | Southern Miss 17, Tulane 14 | Box score |
| Sep 6, 1980 | 15Stanford 35, Oregon 25 | Box score |
| Sep 6, 1980 | Texas A&M 23, Ole Miss 20 | Box score |
| Sep 6, 1980 | Texas Tech 35, UTEP 7 | Box score |
| Sep 6, 1980 | Virginia Tech 16, Wake Forest 7 | Box score |
| Sep 6, 1980 | West Virginia 41, Cincinnati 27 | Box score |
| Sep 6, 1980 | Western Carolina 16, VMI 14 | Box score |
| Sep 6, 1980 | Western Michigan 37, Eastern Michigan 0 | Box score |
| Sep 6, 1980 | Wichita State 31, Southern Illinois 14 | Box score |