| Nov 15, 1980 | Air Force 25, Wyoming 7upset | Box score |
| Nov 15, 1980 | Arizona 63, Pacific 35 | Box score |
| Nov 15, 1980 | Arkansas 27, Texas A&M 24 | Box score |
| Nov 15, 1980 | Ball State 37, Ohio 18 | Box score |
| Nov 15, 1980 | 12Baylor 16, Rice 6 | Box score |
| Nov 15, 1980 | Boston College 27, Syracuse 16 | Box score |
| Nov 15, 1980 | 13BYU 45, Colorado State 14 | Box score |
| Nov 15, 1980 | Central Michigan 22, Western Michigan 10 | Box score |
| Nov 15, 1980 | Chattanooga 27, Illinois State 19 | Box score |
| Nov 15, 1980 | Cornell 24, Columbia 0 | Box score |
| Nov 15, 1980 | Dartmouth 28, Brown 24upset | Box score |
| Nov 15, 1980 | 20Florida 17, Kentucky 15 | Box score |
| Nov 15, 1980 | 1Georgia 31, Auburn 21 | Box score |
| Nov 15, 1980 | Harvard 28, Pennsylvania 17 | Box score |
| Nov 15, 1980 | Hawai’i 24, UNLV 19upset | Box score |
| Nov 15, 1980 | Indiana 26, Illinois 24 | Box score |
| Nov 15, 1980 | Indiana State 33, New Mexico State 28 | Box score |
| Nov 15, 1980 | Kansas 42, Colorado 3 | Box score |
| Nov 15, 1980 | Long Beach State 28, Utah State 27 | Box score |
| Nov 15, 1980 | Louisiana 27, Louisiana Tech 9 | Box score |
| Nov 15, 1980 | Louisville 20, Cincinnati 0 | Box score |
| Nov 15, 1980 | Maryland 34, Clemson 7 | Box score |
| Nov 15, 1980 | McNeese 35, Lamar 3 | Box score |
| Nov 15, 1980 | Miami 24, Vanderbilt 17 | Box score |
| Nov 15, 1980 | Miami (OH) 49, Kent State 14 | Box score |
| Nov 15, 1980 | 11Michigan 26, 16Purdue 0 | Box score |
| Nov 15, 1980 | Michigan State 30, Minnesota 12upset | Box score |
| Nov 15, 1980 | Ole Miss 20, Tennessee 9 | Box score |
| Nov 15, 1980 | 19Mississippi State 55, LSU 31 | Box score |
| Nov 15, 1980 | Navy 19, Georgia Tech 8 | Box score |
| Nov 15, 1980 | 4Nebraska 35, Iowa State 0 | Box score |
| Nov 15, 1980 | 15North Carolina 26, Virginia 3 | Box score |
| Nov 15, 1980 | NC State 38, Duke 21 | Box score |
| Nov 15, 1980 | North Texas 26, UL Monroe 18 | Box score |
| Nov 15, 1980 | 6Notre Dame 7, 5Alabama 0upset | Box score |
| Nov 15, 1980 | 7Ohio State 41, Iowa 7 | Box score |
| Nov 15, 1980 | 10Oklahoma 17, Missouri 7 | Box score |
| Nov 15, 1980 | Oklahoma State 10, Kansas State 0 | Box score |
| Nov 15, 1980 | Oregon 40, Oregon State 21 | Box score |
| Nov 15, 1980 | 9Penn State 50, Temple 7 | Box score |
| Nov 15, 1980 | 8Pittsburgh 45, Army 7 | Box score |
| Nov 15, 1980 | San Diego State 28, UTEP 7 | Box score |
| Nov 15, 1980 | San José State 33, Cal State Fullerton 21 | Box score |
| Nov 15, 1980 | 14South Carolina 39, Wake Forest 38 | Box score |
| Nov 15, 1980 | Southern Miss 33, Richmond 12 | Box score |
| Nov 15, 1980 | Texas 51, TCU 26 | Box score |
| Nov 15, 1980 | Texas Tech 14, 18SMU 0upset | Box score |
| Nov 15, 1980 | Texas–Arlington 36, Arkansas State 14 | Box score |
| Nov 15, 1980 | Toledo 38, Marshall 10 | Box score |
| Nov 15, 1980 | Tulane 21, Memphis 16 | Box score |
| Nov 15, 1980 | Tulsa 41, Southern Illinois 7 | Box score |
| Nov 15, 1980 | 17UCLA 23, Arizona State 14 | Box score |
| Nov 15, 1980 | Villanova 45, Holy Cross 13 | Box score |
| Nov 15, 1980 | Virginia Tech 21, VMI 6 | Box score |
| Nov 15, 1980 | Washington 20, 2USC 10upset | Box score |
| Nov 15, 1980 | Washington State 31, California 17 | Box score |
| Nov 15, 1980 | West Virginia 24, Rutgers 15upset | Box score |
| Nov 15, 1980 | Wichita State 20, West Texas 18 | Box score |
| Nov 15, 1980 | Wisconsin 39, Northwestern 19 | Box score |
| Nov 15, 1980 | Yale 25, Princeton 13 | Box score |