| Nov 22, 1980 | Arizona 24, Oregon State 7 | Box score |
| Nov 22, 1980 | Arizona State 42, Oregon 37 | Box score |
| Nov 22, 1980 | Ball State 28, Indiana State 21 | Box score |
| Nov 22, 1980 | 11Baylor 16, 20Texas 0 | Box score |
| Nov 22, 1980 | 13BYU 56, Utah 6 | Box score |
| Nov 22, 1980 | Brown 31, Columbia 13 | Box score |
| Nov 22, 1980 | California 28, Stanford 23upset | Box score |
| Nov 22, 1980 | Cincinnati 23, Miami (OH) 13upset | Box score |
| Nov 22, 1980 | Clemson 27, 14South Carolina 6upset | Box score |
| Nov 22, 1980 | Cornell 31, Pennsylvania 9 | Box score |
| Nov 22, 1980 | Furman 28, The Citadel 15 | Box score |
| Nov 22, 1980 | Houston 34, Texas Tech 7 | Box score |
| Nov 22, 1980 | Iowa 41, Michigan State 0upset | Box score |
| Nov 22, 1980 | Iowa State 23, Oklahoma State 21upset | Box score |
| Nov 22, 1980 | Kansas State 17, Colorado 14 | Box score |
| Nov 22, 1980 | Kent State 34, Toledo 14upset | Box score |
| Nov 22, 1980 | Long Beach State 21, Drake 7 | Box score |
| Nov 22, 1980 | LSU 24, Tulane 7 | Box score |
| Nov 22, 1980 | UL Monroe 19, Louisiana Tech 14 | Box score |
| Nov 22, 1980 | Louisville 6, Southern Miss 3upset | Box score |
| Nov 22, 1980 | Maryland 31, Virginia 0 | Box score |
| Nov 22, 1980 | McNeese 14, Louisiana 0 | Box score |
| Nov 22, 1980 | Memphis 6, Wichita State 0 | Box score |
| Nov 22, 1980 | Miami 26, North Texas 8 | Box score |
| Nov 22, 1980 | 10Michigan 9, 5Ohio State 3upset | Box score |
| Nov 22, 1980 | 17Mississippi State 19, Ole Miss 14 | Box score |
| Nov 22, 1980 | Missouri 31, Kansas 6 | Box score |
| Nov 22, 1980 | 15North Carolina 44, Duke 21 | Box score |
| Nov 22, 1980 | NC State 36, East Carolina 14 | Box score |
| Nov 22, 1980 | Northern Illinois 38, Eastern Michigan 6 | Box score |
| Nov 22, 1980 | 2Notre Dame 24, Air Force 10 | Box score |
| Nov 22, 1980 | Ohio 21, Bowling Green 20 | Box score |
| Nov 22, 1980 | 9Oklahoma 21, 4Nebraska 17upset | Box score |
| Nov 22, 1980 | Pacific 32, Cal State Fullerton 26 | Box score |
| Nov 22, 1980 | Princeton 27, Dartmouth 24 | Box score |
| Nov 22, 1980 | Purdue 24, Indiana 23 | Box score |
| Nov 22, 1980 | Richmond 26, William & Mary 14 | Box score |
| Nov 22, 1980 | Rutgers 35, Colgate 13 | Box score |
| Nov 22, 1980 | San Diego State 24, New Mexico 22 | Box score |
| Nov 22, 1980 | Syracuse 20, West Virginia 7 | Box score |
| Nov 22, 1980 | Tennessee 45, Kentucky 14 | Box score |
| Nov 22, 1980 | Texas A&M 13, TCU 10 | Box score |
| Nov 22, 1980 | Texas–Arlington 44, Lamar 27 | Box score |
| Nov 22, 1980 | Tulsa 21, New Mexico State 20 | Box score |
| Nov 22, 1980 | 18UCLA 20, 12USC 17upset | Box score |
| Nov 22, 1980 | Utah State 44, San José State 38 | Box score |
| Nov 22, 1980 | Vanderbilt 31, Chattanooga 29upset | Box score |
| Nov 22, 1980 | Villanova 23, Temple 7 | Box score |
| Nov 22, 1980 | Wake Forest 28, App State 16 | Box score |
| Nov 22, 1980 | 16Washington 30, Washington State 23 | Box score |
| Nov 22, 1980 | West Texas 23, Southern Illinois 20 | Box score |
| Nov 22, 1980 | Wisconsin 25, Minnesota 7 | Box score |
| Nov 22, 1980 | Wyoming 52, UTEP 7 | Box score |
| Nov 22, 1980 | Yale 14, Harvard 0 | Box score |
| Nov 23, 1980 | SMU 31, Arkansas 7 | Box score |