| Nov 8, 1980 | 6Alabama 28, LSU 7 | Box score |
| Nov 8, 1980 | VMI 16, App State 16 | Box score |
| Nov 8, 1980 | Arizona State 34, California 6 | Box score |
| Nov 8, 1980 | Army 47, Air Force 24 | Box score |
| Nov 8, 1980 | Auburn 31, Southern Miss 0 | Box score |
| Nov 8, 1980 | Ball State 34, Kent State 7 | Box score |
| Nov 8, 1980 | 16Baylor 42, Arkansas 15 | Box score |
| Nov 8, 1980 | 13BYU 41, North Texas 23 | Box score |
| Nov 8, 1980 | Central Michigan 32, Bowling Green 10 | Box score |
| Nov 8, 1980 | Chattanooga 39, Western Carolina 14 | Box score |
| Nov 8, 1980 | Cincinnati 14, Memphis 10 | Box score |
| Nov 8, 1980 | Colorado State 37, UTEP 7 | Box score |
| Nov 8, 1980 | Cornell 24, Yale 6upset | Box score |
| Nov 8, 1980 | Dartmouth 48, Columbia 0 | Box score |
| Nov 8, 1980 | 3Florida State 31, Virginia Tech 7 | Box score |
| Nov 8, 1980 | Fresno State 31, Southern Illinois 14upset | Box score |
| Nov 8, 1980 | 2Georgia 26, 20Florida 21 | Box score |
| Nov 8, 1980 | Harvard 24, William & Mary 13 | Box score |
| Nov 8, 1980 | Hawai’i 31, San Diego State 6 | Box score |
| Nov 8, 1980 | Illinois State 15, Eastern Michigan 7 | Box score |
| Nov 8, 1980 | Kentucky 31, Vanderbilt 10 | Box score |
| Nov 8, 1980 | Lamar 23, Arkansas State 22 | Box score |
| Nov 8, 1980 | Long Beach State 20, Cal State Fullerton 10 | Box score |
| Nov 8, 1980 | Louisiana 30, Texas–Arlington 13 | Box score |
| Nov 8, 1980 | McNeese 45, Louisiana Tech 8 | Box score |
| Nov 8, 1980 | Miami 23, East Carolina 10 | Box score |
| Nov 8, 1980 | Miami (OH) 34, Western Michigan 24 | Box score |
| Nov 8, 1980 | 12Michigan 24, Wisconsin 0 | Box score |
| Nov 8, 1980 | Michigan State 42, Northwestern 10 | Box score |
| Nov 8, 1980 | Minnesota 31, Indiana 7 | Box score |
| Nov 8, 1980 | Missouri 14, Iowa State 10 | Box score |
| Nov 8, 1980 | Navy 6, Syracuse 3 | Box score |
| Nov 8, 1980 | 5Nebraska 55, Kansas State 8 | Box score |
| Nov 8, 1980 | UNLV 33, Wyoming 26 | Box score |
| Nov 8, 1980 | Wichita State 14, New Mexico State 14 | Box score |
| Nov 8, 1980 | 14North Carolina 24, Clemson 19 | Box score |
| Nov 8, 1980 | Georgia Tech 3, 1Notre Dame 3 | Box score |
| Nov 8, 1980 | Ohio 28, Marshall 20 | Box score |
| Nov 8, 1980 | 7Ohio State 49, Illinois 42 | Box score |
| Nov 8, 1980 | 11Oklahoma 21, Kansas 19 | Box score |
| Nov 8, 1980 | Oklahoma State 42, Colorado 7 | Box score |
| Nov 8, 1980 | Oregon 20, 8UCLA 14upset | Box score |
| Nov 8, 1980 | 10Penn State 21, NC State 13 | Box score |
| Nov 8, 1980 | 9Pittsburgh 41, Louisville 23 | Box score |
| Nov 8, 1980 | 17Purdue 58, Iowa 13 | Box score |
| Nov 8, 1980 | Rutgers 19, Virginia 17 | Box score |
| Nov 8, 1980 | San José State 28, Pacific 23 | Box score |
| Nov 8, 1980 | 15South Carolina 45, The Citadel 24 | Box score |
| Nov 8, 1980 | 4USC 34, Stanford 9 | Box score |
| Nov 8, 1980 | 18SMU 34, Rice 14 | Box score |
| Nov 8, 1980 | Texas 15, Houston 13 | Box score |
| Nov 8, 1980 | TCU 24, Texas Tech 17upset | Box score |
| Nov 8, 1980 | Toledo 13, Northern Illinois 6 | Box score |
| Nov 8, 1980 | Tulsa 30, Indiana State 7 | Box score |
| Nov 8, 1980 | Utah 49, New Mexico 21 | Box score |
| Nov 8, 1980 | Villanova 34, Pennsylvania 3 | Box score |
| Nov 8, 1980 | Wake Forest 27, Duke 24 | Box score |
| Nov 8, 1980 | Washington 45, Arizona 22 | Box score |
| Nov 8, 1980 | Washington State 28, Oregon State 7 | Box score |
| Nov 8, 1980 | West Virginia 41, Temple 28upset | Box score |