| Nov 1, 1980 | App State 27, Western Carolina 24 | Box score |
| Nov 1, 1980 | Arizona 23, 2UCLA 17upset | Box score |
| Nov 1, 1980 | Boston College 23, Air Force 0 | Box score |
| Nov 1, 1980 | Bowling Green 24, Ball State 21 | Box score |
| Nov 1, 1980 | 17BYU 83, UTEP 7 | Box score |
| Nov 1, 1980 | Central Michigan 51, Eastern Michigan 15 | Box score |
| Nov 1, 1980 | Clemson 35, Wake Forest 33 | Box score |
| Nov 1, 1980 | Colorado 17, Iowa State 9 | Box score |
| Nov 1, 1980 | Colorado State 28, Wyoming 25 | Box score |
| Nov 1, 1980 | Drake 38, Wichita State 15 | Box score |
| Nov 1, 1980 | Duke 17, Georgia Tech 12 | Box score |
| Nov 1, 1980 | East Carolina 31, William & Mary 23 | Box score |
| Nov 1, 1980 | Florida 21, Auburn 10 | Box score |
| Nov 1, 1980 | 5Florida State 45, Tulsa 2 | Box score |
| Nov 1, 1980 | Furman 35, Marshall 0 | Box score |
| Nov 1, 1980 | 4Georgia 13, 14South Carolina 10 | Box score |
| Nov 1, 1980 | Harvard 17, Brown 16 | Box score |
| Nov 1, 1980 | Hawai’i 31, Cal State Fullerton 21 | Box score |
| Nov 1, 1980 | Holy Cross 26, Columbia 0 | Box score |
| Nov 1, 1980 | Houston 37, TCU 5 | Box score |
| Nov 1, 1980 | Indiana State 37, West Texas 18 | Box score |
| Nov 1, 1980 | Iowa 22, Wisconsin 13 | Box score |
| Nov 1, 1980 | Kansas 20, Kansas State 18 | Box score |
| Nov 1, 1980 | Long Beach State 34, Fresno State 9 | Box score |
| Nov 1, 1980 | Louisiana 21, Southern Illinois 3 | Box score |
| Nov 1, 1980 | LSU 38, Ole Miss 16 | Box score |
| Nov 1, 1980 | Louisiana Tech 28, Arkansas State 0 | Box score |
| Nov 1, 1980 | Maryland 24, NC State 0 | Box score |
| Nov 1, 1980 | McNeese 31, Texas–Arlington 17 | Box score |
| Nov 1, 1980 | 18Michigan 35, Indiana 0 | Box score |
| Nov 1, 1980 | Minnesota 21, Illinois 18 | Box score |
| Nov 1, 1980 | Mississippi State 6, 1Alabama 3upset | Box score |
| Nov 1, 1980 | 8Nebraska 38, 15Missouri 16 | Box score |
| Nov 1, 1980 | UNLV 72, New Mexico 7 | Box score |
| Nov 1, 1980 | North Texas 38, New Mexico State 28 | Box score |
| Nov 1, 1980 | Northern Illinois 35, Kent State 14 | Box score |
| Nov 1, 1980 | 3Notre Dame 33, Navy 0 | Box score |
| Nov 1, 1980 | 9Ohio State 48, Michigan State 16 | Box score |
| Nov 1, 1980 | 16Oklahoma 41, 6North Carolina 7upset | Box score |
| Nov 1, 1980 | Oklahoma State 15, San Diego State 6 | Box score |
| Nov 1, 1980 | Oregon 20, Washington State 10 | Box score |
| Nov 1, 1980 | 13Penn State 27, Miami 12 | Box score |
| Nov 1, 1980 | 11Pittsburgh 43, Syracuse 6 | Box score |
| Nov 1, 1980 | Princeton 28, Pennsylvania 21 | Box score |
| Nov 1, 1980 | 20Purdue 52, Northwestern 31 | Box score |
| Nov 1, 1980 | Rice 17, Arkansas 16upset | Box score |
| Nov 1, 1980 | Richmond 24, Cincinnati 10 | Box score |
| Nov 1, 1980 | Rutgers 37, Army 21 | Box score |
| Nov 1, 1980 | San José State 30, 10Baylor 22upset | Box score |
| Nov 1, 1980 | 7USC 60, California 7 | Box score |
| Nov 1, 1980 | 19SMU 27, Texas A&M 0 | Box score |
| Nov 1, 1980 | Southern Miss 36, Lamar 10 | Box score |
| Nov 1, 1980 | Stanford 54, Oregon State 13 | Box score |
| Nov 1, 1980 | Temple 17, Louisville 12 | Box score |
| Nov 1, 1980 | Texas Tech 24, 12Texas 20upset | Box score |
| Nov 1, 1980 | Toledo 17, Miami (OH) 14 | Box score |
| Nov 1, 1980 | Tulane 24, Kentucky 22 | Box score |
| Nov 1, 1980 | Utah State 21, Pacific 7 | Box score |
| Nov 1, 1980 | Vanderbilt 14, Memphis 10upset | Box score |
| Nov 1, 1980 | Virginia 16, Tennessee 13upset | Box score |
| Nov 1, 1980 | Virginia Tech 34, West Virginia 11 | Box score |
| Nov 1, 1980 | Washington 25, Arizona State 0 | Box score |
| Nov 1, 1980 | Western Michigan 13, Ohio 7 | Box score |
| Nov 1, 1980 | Yale 35, Dartmouth 7 | Box score |