| Oct 5, 1979 | 20BYU 38, Hawai’i 15 | Box score |
| Oct 6, 1979 | 2Alabama 38, Wichita State 0 | Box score |
| Oct 6, 1979 | 13Arkansas 16, TCU 13 | Box score |
| Oct 6, 1979 | Arkansas State 24, Richmond 3 | Box score |
| Oct 6, 1979 | Auburn 44, 14NC State 31upset | Box score |
| Oct 6, 1979 | Brown 31, Princeton 12 | Box score |
| Oct 6, 1979 | Central Michigan 26, Ohio 0 | Box score |
| Oct 6, 1979 | Chattanooga 24, App State 21 | Box score |
| Oct 6, 1979 | The Citadel 21, Western Carolina 19 | Box score |
| Oct 6, 1979 | Clemson 17, Virginia 7 | Box score |
| Oct 6, 1979 | Columbia 12, Pennsylvania 7 | Box score |
| Oct 6, 1979 | Army 17, Duke 17 | Box score |
| Oct 6, 1979 | 9Florida State 27, Louisville 0 | Box score |
| Oct 6, 1979 | Georgia 24, Ole Miss 21 | Box score |
| Oct 6, 1979 | Holy Cross 13, Dartmouth 7upset | Box score |
| Oct 6, 1979 | 6Houston 13, Baylor 10 | Box score |
| Oct 6, 1979 | Indiana 3, Wisconsin 0 | Box score |
| Oct 6, 1979 | Indiana State 18, Ball State 13 | Box score |
| Oct 6, 1979 | Iowa 13, Illinois 7 | Box score |
| Oct 6, 1979 | Kent State 18, Western Michigan 13upset | Box score |
| Oct 6, 1979 | 17LSU 20, Florida 3 | Box score |
| Oct 6, 1979 | Louisiana Tech 17, Louisiana 0 | Box score |
| Oct 6, 1979 | McNeese 14, Texas–Arlington 13 | Box score |
| Oct 6, 1979 | Miami (OH) 28, Marshall 0 | Box score |
| Oct 6, 1979 | 11Michigan 21, 16Michigan State 7 | Box score |
| Oct 6, 1979 | Minnesota 31, 12Purdue 14upset | Box score |
| Oct 6, 1979 | Mississippi State 28, 19Tennessee 9upset | Box score |
| Oct 6, 1979 | Navy 13, Air Force 9 | Box score |
| Oct 6, 1979 | 5Nebraska 57, New Mexico State 0 | Box score |
| Oct 6, 1979 | 18North Carolina 35, Cincinnati 14 | Box score |
| Oct 6, 1979 | Eastern Michigan 0, Northern Illinois 0 | Box score |
| Oct 6, 1979 | 10Notre Dame 21, Georgia Tech 13 | Box score |
| Oct 6, 1979 | 8Ohio State 16, Northwestern 7 | Box score |
| Oct 6, 1979 | 3Oklahoma 49, Colorado 24 | Box score |
| Oct 6, 1979 | Oregon 19, California 14 | Box score |
| Oct 6, 1979 | Pacific 24, Iowa State 7upset | Box score |
| Oct 6, 1979 | Penn State 27, Maryland 7 | Box score |
| Oct 6, 1979 | Pittsburgh 28, Boston College 7 | Box score |
| Oct 6, 1979 | San Diego State 35, New Mexico 7 | Box score |
| Oct 6, 1979 | San José State 23, Cal State Fullerton 0 | Box score |
| Oct 6, 1979 | South Carolina 23, Oklahoma State 16 | Box score |
| Oct 6, 1979 | 1USC 50, Washington State 21 | Box score |
| Oct 6, 1979 | Southern Illinois 7, Illinois State 0 | Box score |
| Oct 6, 1979 | Southern Miss 30, North Texas 10 | Box score |
| Oct 6, 1979 | Stanford 27, UCLA 24 | Box score |
| Oct 6, 1979 | Syracuse 45, Kansas 27 | Box score |
| Oct 6, 1979 | Temple 41, Rutgers 20 | Box score |
| Oct 6, 1979 | 4Texas 26, Rice 9 | Box score |
| Oct 6, 1979 | Texas Tech 21, Texas A&M 20 | Box score |
| Oct 6, 1979 | Toledo 23, Bowling Green 17 | Box score |
| Oct 6, 1979 | Tulane 42, Vanderbilt 14 | Box score |
| Oct 6, 1979 | Tulsa 9, Kansas State 6 | Box score |
| Oct 6, 1979 | Utah 21, Colorado State 16 | Box score |
| Oct 6, 1979 | Utah State 51, Long Beach State 28 | Box score |
| Oct 6, 1979 | Wake Forest 19, Virginia Tech 14upset | Box score |
| Oct 6, 1979 | 7Washington 41, Oregon State 0 | Box score |
| Oct 6, 1979 | Lamar 12, West Texas 12 | Box score |
| Oct 6, 1979 | West Virginia 10, Kentucky 6upset | Box score |
| Oct 6, 1979 | Wyoming 23, UTEP 3 | Box score |
| Oct 6, 1979 | Yale 27, Colgate 0 | Box score |