| Sep 22, 1979 | 2Alabama 45, Baylor 0 | Box score |
| Sep 22, 1979 | App State 35, Western Carolina 27 | Box score |
| Sep 22, 1979 | Arizona State 49, Toledo 0 | Box score |
| Sep 22, 1979 | 15Arkansas 27, Oklahoma State 7 | Box score |
| Sep 22, 1979 | Arkansas State 24, Southern Illinois 16 | Box score |
| Sep 22, 1979 | Army 17, Stanford 13upset | Box score |
| Sep 22, 1979 | Auburn 31, Southern Miss 9 | Box score |
| Sep 22, 1979 | Ball State 35, Kent State 10 | Box score |
| Sep 22, 1979 | Boston College 34, Villanova 7 | Box score |
| Sep 22, 1979 | California 13, San José State 10 | Box score |
| Sep 22, 1979 | Central Michigan 24, Bowling Green 0 | Box score |
| Sep 22, 1979 | Chattanooga 45, Furman 14 | Box score |
| Sep 22, 1979 | The Citadel 27, Vanderbilt 14 | Box score |
| Sep 22, 1979 | Clemson 12, Georgia 7 | Box score |
| Sep 22, 1979 | Cornell 52, Pennsylvania 13 | Box score |
| Sep 22, 1979 | Drake 13, Colorado 9upset | Box score |
| Sep 22, 1979 | 14Florida State 40, Miami 23 | Box score |
| Sep 22, 1979 | Florida 7, Georgia Tech 7 | Box score |
| Sep 22, 1979 | Harvard 26, Columbia 7 | Box score |
| Sep 22, 1979 | Hawai’i 20, New Mexico 3 | Box score |
| Sep 22, 1979 | Illinois 27, Air Force 19 | Box score |
| Sep 22, 1979 | Illinois State 24, Eastern Michigan 15 | Box score |
| Sep 22, 1979 | Indiana 18, Kentucky 10 | Box score |
| Sep 22, 1979 | Indiana State 40, New Mexico State 23 | Box score |
| Sep 22, 1979 | Kansas State 22, Oregon State 16 | Box score |
| Sep 22, 1979 | Lamar 19, Louisiana Tech 7 | Box score |
| Sep 22, 1979 | Louisiana 19, West Texas 10 | Box score |
| Sep 22, 1979 | LSU 47, Rice 3 | Box score |
| Sep 22, 1979 | Louisville 22, Cincinnati 19 | Box score |
| Sep 22, 1979 | Maryland 35, Mississippi State 14 | Box score |
| Sep 22, 1979 | McNeese 12, UL Monroe 10 | Box score |
| Sep 22, 1979 | Memphis 16, Wichita State 10 | Box score |
| Sep 22, 1979 | 11Michigan 28, Kansas 7 | Box score |
| Sep 22, 1979 | 8Michigan State 24, Miami (OH) 21 | Box score |
| Sep 22, 1979 | 9Missouri 33, Ole Miss 7 | Box score |
| Sep 22, 1979 | 7Nebraska 24, Iowa 21 | Box score |
| Sep 22, 1979 | North Carolina 17, 13Pittsburgh 7upset | Box score |
| Sep 22, 1979 | 19NC State 38, West Virginia 14 | Box score |
| Sep 22, 1979 | Ohio 35, Marshall 0 | Box score |
| Sep 22, 1979 | 16Ohio State 45, Washington State 29 | Box score |
| Sep 22, 1979 | 3Oklahoma 49, Tulsa 13 | Box score |
| Sep 22, 1979 | Princeton 16, Dartmouth 0upset | Box score |
| Sep 22, 1979 | 17Purdue 28, 5Notre Dame 22upset | Box score |
| Sep 22, 1979 | San Diego State 32, Fresno State 23 | Box score |
| Sep 22, 1979 | South Carolina 35, Duke 0 | Box score |
| Sep 22, 1979 | 1USC 48, Minnesota 14 | Box score |
| Sep 22, 1979 | 18SMU 20, North Texas 9 | Box score |
| Sep 22, 1979 | Syracuse 54, Northwestern 21 | Box score |
| Sep 22, 1979 | Tennessee 51, Utah 18 | Box score |
| Sep 22, 1979 | 4Texas 17, Iowa State 9 | Box score |
| Sep 22, 1979 | Texas A&M 27, 6Penn State 14upset | Box score |
| Sep 22, 1979 | Arizona 14, Texas Tech 14 | Box score |
| Sep 22, 1979 | UTEP 17, UNLV 15 | Box score |
| Sep 22, 1979 | Tulane 33, TCU 19 | Box score |
| Sep 22, 1979 | 20UCLA 37, Wisconsin 12 | Box score |
| Sep 22, 1979 | Utah State 24, Colorado State 0 | Box score |
| Sep 22, 1979 | Virginia 19, VMI 0 | Box score |
| Sep 22, 1979 | Virginia Tech 35, William & Mary 14 | Box score |
| Sep 22, 1979 | Wake Forest 23, East Carolina 20upset | Box score |
| Sep 22, 1979 | 12Washington 21, Oregon 17 | Box score |
| Sep 22, 1979 | Western Michigan 45, Northern Illinois 17 | Box score |
| Sep 22, 1979 | Wyoming 9, Richmond 7 | Box score |
| Sep 22, 1979 | Yale 13, Brown 12 | Box score |