| Sep 15, 1979 | 17Arkansas 36, Colorado State 3 | Box score |
| Sep 15, 1979 | Auburn 26, Kansas State 18 | Box score |
| Sep 15, 1979 | Baylor 17, Texas A&M 7 | Box score |
| Sep 15, 1979 | California 10, Arizona 7 | Box score |
| Sep 15, 1979 | Chattanooga 24, Louisiana Tech 7 | Box score |
| Sep 15, 1979 | Duke 28, East Carolina 14 | Box score |
| Sep 15, 1979 | 18Florida State 31, Arizona State 3 | Box score |
| Sep 15, 1979 | 13Houston 14, Florida 10 | Box score |
| Sep 15, 1979 | Indiana 44, Vanderbilt 13 | Box score |
| Sep 15, 1979 | Iowa State 38, Bowling Green 10 | Box score |
| Sep 15, 1979 | LSU 44, Colorado 0 | Box score |
| Sep 15, 1979 | UL Monroe 18, Arkansas State 17 | Box score |
| Sep 15, 1979 | Maryland 19, Clemson 0 | Box score |
| Sep 15, 1979 | McNeese 21, West Texas 0 | Box score |
| Sep 15, 1979 | Miami 24, Louisville 12 | Box score |
| Sep 15, 1979 | Miami (OH) 15, Kentucky 14 | Box score |
| Sep 15, 1979 | 10Michigan State 41, Oregon 17 | Box score |
| Sep 15, 1979 | Ole Miss 38, Memphis 34 | Box score |
| Sep 15, 1979 | 11Missouri 14, Illinois 6 | Box score |
| Sep 15, 1979 | Navy 26, The Citadel 7 | Box score |
| Sep 15, 1979 | 8Nebraska 35, Utah State 14 | Box score |
| Sep 15, 1979 | New Mexico State 14, UTEP 13 | Box score |
| Sep 15, 1979 | 19NC State 31, Virginia 27 | Box score |
| Sep 15, 1979 | North Texas 19, Texas–Arlington 14 | Box score |
| Sep 15, 1979 | Northwestern 27, Wyoming 22 | Box score |
| Sep 15, 1979 | 9Notre Dame 12, 6Michigan 10upset | Box score |
| Sep 15, 1979 | Ohio 20, Eastern Michigan 7 | Box score |
| Sep 15, 1979 | 15Ohio State 21, Minnesota 17 | Box score |
| Sep 15, 1979 | 3Oklahoma 21, Iowa 6 | Box score |
| Sep 15, 1979 | Oklahoma State 16, Wichita State 6 | Box score |
| Sep 15, 1979 | 7Penn State 45, Rutgers 10 | Box score |
| Sep 15, 1979 | 16Pittsburgh 24, Kansas 0 | Box score |
| Sep 15, 1979 | Rice 21, Tulane 17 | Box score |
| Sep 15, 1979 | South Carolina 24, Western Michigan 7 | Box score |
| Sep 15, 1979 | 1USC 42, Oregon State 5 | Box score |
| Sep 15, 1979 | Southern Illinois 18, Tennessee State 16 | Box score |
| Sep 15, 1979 | 20SMU 27, TCU 7 | Box score |
| Sep 15, 1979 | Southern Miss 24, Cincinnati 6 | Box score |
| Sep 15, 1979 | Stanford 45, San José State 29 | Box score |
| Sep 15, 1979 | Syracuse 24, West Virginia 14 | Box score |
| Sep 15, 1979 | Temple 43, Drake 21 | Box score |
| Sep 15, 1979 | Tennessee 28, Boston College 16 | Box score |
| Sep 15, 1979 | Texas Tech 17, New Mexico 7 | Box score |
| Sep 15, 1979 | Toledo 31, Ball State 14upset | Box score |
| Sep 15, 1979 | Tulsa 28, Louisiana 20 | Box score |
| Sep 15, 1979 | UCLA 31, 5Purdue 21upset | Box score |
| Sep 15, 1979 | VMI 17, Richmond 7 | Box score |
| Sep 15, 1979 | Virginia Tech 41, App State 32 | Box score |
| Sep 15, 1979 | Wake Forest 22, 12Georgia 21upset | Box score |
| Sep 15, 1979 | 14Washington 41, Utah 7 | Box score |
| Sep 15, 1979 | Western Carolina 24, Marshall 0 | Box score |
| Sep 15, 1979 | William & Mary 28, Colgate 15 | Box score |
| Sep 15, 1979 | Wisconsin 38, Air Force 0 | Box score |