| Sep 8, 1979 | 2Alabama 30, Georgia Tech 6 | Box score |
| Sep 8, 1979 | Arizona 22, Washington State 7 | Box score |
| Sep 8, 1979 | Baylor 20, Lamar 7 | Box score |
| Sep 8, 1979 | Bowling Green 32, Eastern Michigan 6 | Box score |
| Sep 8, 1979 | BYU 18, 14Texas A&M 17upset | Box score |
| Sep 8, 1979 | California 17, 18Arizona State 9upset | Box score |
| Sep 8, 1979 | Central Michigan 10, Western Michigan 0 | Box score |
| Sep 8, 1979 | Clemson 21, Furman 0 | Box score |
| Sep 8, 1979 | Drake 14, New Mexico State 13 | Box score |
| Sep 8, 1979 | 19Florida State 17, Southern Miss 14 | Box score |
| Sep 8, 1979 | 16Houston 24, UCLA 16 | Box score |
| Sep 8, 1979 | Indiana 30, Iowa 26 | Box score |
| Sep 8, 1979 | Indiana State 28, Wichita State 9 | Box score |
| Sep 8, 1979 | Marshall 31, Toledo 14 | Box score |
| Sep 8, 1979 | Maryland 24, Villanova 20 | Box score |
| Sep 8, 1979 | Memphis 14, Mississippi State 13upset | Box score |
| Sep 8, 1979 | Miami (OH) 27, Ball State 3 | Box score |
| Sep 8, 1979 | 7Michigan 49, Northwestern 7 | Box score |
| Sep 8, 1979 | 10Michigan State 33, Illinois 16 | Box score |
| Sep 8, 1979 | Minnesota 24, Ohio 10 | Box score |
| Sep 8, 1979 | 12Missouri 45, San Diego State 15 | Box score |
| Sep 8, 1979 | UNLV 35, Cal State Fullerton 14 | Box score |
| Sep 8, 1979 | New Mexico 35, Oregon State 16 | Box score |
| Sep 8, 1979 | North Carolina 28, South Carolina 0 | Box score |
| Sep 8, 1979 | NC State 34, East Carolina 20 | Box score |
| Sep 8, 1979 | Ohio State 31, Syracuse 8 | Box score |
| Sep 8, 1979 | Oklahoma State 25, North Texas 7 | Box score |
| Sep 8, 1979 | Oregon 33, Colorado 19upset | Box score |
| Sep 8, 1979 | 6Purdue 41, Wisconsin 20 | Box score |
| Sep 8, 1979 | Rutgers 28, Holy Cross 0 | Box score |
| Sep 8, 1979 | 1USC 21, Texas Tech 7 | Box score |
| Sep 8, 1979 | Southern Illinois 17, Louisiana 7 | Box score |
| Sep 8, 1979 | SMU 35, Rice 17 | Box score |
| Sep 8, 1979 | Temple 38, West Virginia 16 | Box score |
| Sep 8, 1979 | Texas–Arlington 10, West Texas 6 | Box score |
| Sep 8, 1979 | UTEP 31, Pacific 7 | Box score |
| Sep 8, 1979 | Tulane 33, 13Stanford 10upset | Box score |
| Sep 8, 1979 | Tulsa 24, Air Force 7 | Box score |
| Sep 8, 1979 | Utah 27, Hawai’i 23 | Box score |
| Sep 8, 1979 | San José State 48, Utah State 48 | Box score |
| Sep 8, 1979 | Virginia 31, Richmond 0 | Box score |
| Sep 8, 1979 | VMI 7, William & Mary 3 | Box score |
| Sep 8, 1979 | Virginia Tech 15, Louisville 14 | Box score |
| Sep 8, 1979 | Wake Forest 30, App State 23 | Box score |
| Sep 8, 1979 | 15Washington 38, Wyoming 2 | Box score |