| Oct 27, 1978 | 10UCLA 24, Arizona 14 | Box score |
| Oct 28, 1978 | Air Force 26, Kent State 10 | Box score |
| Oct 28, 1978 | 3Alabama 35, Virginia Tech 0 | Box score |
| Oct 28, 1978 | Arkansas State 27, Texas–Arlington 7 | Box score |
| Oct 28, 1978 | Army 28, Colgate 3 | Box score |
| Oct 28, 1978 | Auburn 21, Wake Forest 7 | Box score |
| Oct 28, 1978 | Ball State 21, Eastern Michigan 0 | Box score |
| Oct 28, 1978 | Baylor 28, TCU 21 | Box score |
| Oct 28, 1978 | Brown 31, Holy Cross 25 | Box score |
| Oct 28, 1978 | Cal State Fullerton 37, Fresno State 8upset | Box score |
| Oct 28, 1978 | Central Michigan 38, Bowling Green 7 | Box score |
| Oct 28, 1978 | Cincinnati 38, Louisiana 13 | Box score |
| Oct 28, 1978 | 20Clemson 33, NC State 10 | Box score |
| Oct 28, 1978 | Colorado 28, 13Missouri 27upset | Box score |
| Oct 28, 1978 | Dartmouth 14, Cornell 7 | Box score |
| Oct 28, 1978 | East Carolina 21, Richmond 14 | Box score |
| Oct 28, 1978 | Florida State 38, Southern Miss 16 | Box score |
| Oct 28, 1978 | Furman 42, Marshall 12 | Box score |
| Oct 28, 1978 | 16Georgia 17, Kentucky 16 | Box score |
| Oct 28, 1978 | Georgia Tech 17, Florida 13 | Box score |
| Oct 28, 1978 | Princeton 24, Harvard 24 | Box score |
| Oct 28, 1978 | 11Houston 20, 9Arkansas 9upset | Box score |
| Oct 28, 1978 | Indiana 31, Illinois 10 | Box score |
| Oct 28, 1978 | Iowa State 13, Kansas 7 | Box score |
| Oct 28, 1978 | Long Beach State 27, San Diego State 25 | Box score |
| Oct 28, 1978 | UL Monroe 14, Indiana State 0 | Box score |
| Oct 28, 1978 | Louisville 33, William & Mary 21 | Box score |
| Oct 28, 1978 | 5Maryland 27, Duke 0 | Box score |
| Oct 28, 1978 | McNeese 28, Chattanooga 24 | Box score |
| Oct 28, 1978 | Miami (OH) 28, Toledo 7 | Box score |
| Oct 28, 1978 | 8Michigan 42, Minnesota 10 | Box score |
| Oct 28, 1978 | Michigan State 55, Wisconsin 2 | Box score |
| Oct 28, 1978 | Ole Miss 35, Vanderbilt 10 | Box score |
| Oct 28, 1978 | Mississippi State 34, Tennessee 21 | Box score |
| Oct 28, 1978 | 18Navy 21, 15Pittsburgh 11upset | Box score |
| Oct 28, 1978 | 4Nebraska 22, Oklahoma State 14 | Box score |
| Oct 28, 1978 | New Mexico 21, UTEP 0 | Box score |
| Oct 28, 1978 | New Mexico State 31, Wichita State 21upset | Box score |
| Oct 28, 1978 | North Carolina 24, South Carolina 22 | Box score |
| Oct 28, 1978 | North Texas 16, Louisiana Tech 14 | Box score |
| Oct 28, 1978 | Northern Illinois 14, Southern Illinois 13upset | Box score |
| Oct 28, 1978 | 19Notre Dame 20, Miami 0 | Box score |
| Oct 28, 1978 | Ohio 10, Western Michigan 7upset | Box score |
| Oct 28, 1978 | Ohio State 63, Northwestern 20 | Box score |
| Oct 28, 1978 | 1Oklahoma 56, Kansas State 19 | Box score |
| Oct 28, 1978 | Oregon 31, Washington State 7upset | Box score |
| Oct 28, 1978 | Pacific 27, Hawai’i 17 | Box score |
| Oct 28, 1978 | 2Penn State 49, West Virginia 21 | Box score |
| Oct 28, 1978 | 17Purdue 34, Iowa 7 | Box score |
| Oct 28, 1978 | Rutgers 69, Columbia 0 | Box score |
| Oct 28, 1978 | 6USC 42, California 17 | Box score |
| Oct 28, 1978 | Stanford 24, Oregon State 6 | Box score |
| Oct 28, 1978 | 7Texas 22, SMU 3 | Box score |
| Oct 28, 1978 | Texas A&M 38, Rice 21 | Box score |
| Oct 28, 1978 | Tulane 41, Memphis 24 | Box score |
| Oct 28, 1978 | Tulsa 44, Drake 20 | Box score |
| Oct 28, 1978 | Utah State 31, San José State 21 | Box score |
| Oct 28, 1978 | Washington 41, 12Arizona State 7upset | Box score |
| Oct 28, 1978 | Western Carolina 41, VMI 12upset | Box score |
| Oct 28, 1978 | Wyoming 13, Colorado State 3 | Box score |
| Oct 28, 1978 | Pennsylvania 17, Yale 17 | Box score |