| Oct 21, 1978 | 4Alabama 30, Tennessee 17 | Box score |
| Oct 21, 1978 | App State 42, The Citadel 14 | Box score |
| Oct 21, 1978 | Arkansas State 6, McNeese 3 | Box score |
| Oct 21, 1978 | Ball State 14, Illinois State 7 | Box score |
| Oct 21, 1978 | Baylor 24, 12Texas A&M 6upset | Box score |
| Oct 21, 1978 | BYU 44, UTEP 0 | Box score |
| Oct 21, 1978 | Brown 21, Cornell 13 | Box score |
| Oct 21, 1978 | Cal State Fullerton 34, Long Beach State 9upset | Box score |
| Oct 21, 1978 | Central Michigan 34, Northern Illinois 7 | Box score |
| Oct 21, 1978 | Chattanooga 13, Furman 9 | Box score |
| Oct 21, 1978 | Clemson 28, Duke 8 | Box score |
| Oct 21, 1978 | Yale 3, Columbia 3 | Box score |
| Oct 21, 1978 | Florida 31, Army 7 | Box score |
| Oct 21, 1978 | 18Georgia 31, Vanderbilt 10 | Box score |
| Oct 21, 1978 | Georgia Tech 24, Auburn 10 | Box score |
| Oct 21, 1978 | Harvard 24, Dartmouth 19 | Box score |
| Oct 21, 1978 | 11Houston 42, SMU 28 | Box score |
| Oct 21, 1978 | Kent State 20, Marshall 17 | Box score |
| Oct 21, 1978 | 16LSU 21, Kentucky 0 | Box score |
| Oct 21, 1978 | 6Maryland 39, Wake Forest 0 | Box score |
| Oct 21, 1978 | Miami 17, Utah State 16 | Box score |
| Oct 21, 1978 | Miami (OH) 18, Bowling Green 7 | Box score |
| Oct 21, 1978 | 9Michigan 42, Wisconsin 0 | Box score |
| Oct 21, 1978 | Michigan State 49, Indiana 14 | Box score |
| Oct 21, 1978 | Minnesota 38, Northwestern 14 | Box score |
| Oct 21, 1978 | 13Missouri 56, Kansas State 14 | Box score |
| Oct 21, 1978 | 17Navy 9, William & Mary 0 | Box score |
| Oct 21, 1978 | 5Nebraska 52, Colorado 14 | Box score |
| Oct 21, 1978 | UNLV 33, Colorado State 6upset | Box score |
| Oct 21, 1978 | New Mexico 35, New Mexico State 20 | Box score |
| Oct 21, 1978 | NC State 34, North Carolina 7 | Box score |
| Oct 21, 1978 | 20Notre Dame 38, Air Force 15 | Box score |
| Oct 21, 1978 | Ohio State 31, Iowa 7 | Box score |
| Oct 21, 1978 | 1Oklahoma 34, Iowa State 6 | Box score |
| Oct 21, 1978 | Oklahoma State 21, Kansas 7 | Box score |
| Oct 21, 1978 | 2Penn State 45, Syracuse 15 | Box score |
| Oct 21, 1978 | 15Pittsburgh 7, Florida State 3 | Box score |
| Oct 21, 1978 | Princeton 13, Colgate 12 | Box score |
| Oct 21, 1978 | 19Purdue 13, Illinois 0 | Box score |
| Oct 21, 1978 | Rutgers 24, Villanova 9 | Box score |
| Oct 21, 1978 | San Diego State 31, Pacific 28 | Box score |
| Oct 21, 1978 | San José State 26, Fresno State 16 | Box score |
| Oct 21, 1978 | South Carolina 18, Ole Miss 17 | Box score |
| Oct 21, 1978 | 7USC 38, Oregon State 7 | Box score |
| Oct 21, 1978 | Southern Miss 13, Memphis 10 | Box score |
| Oct 21, 1978 | Stanford 43, Washington State 27 | Box score |
| Oct 21, 1978 | Temple 28, West Virginia 27 | Box score |
| Oct 21, 1978 | 8Texas 28, 3Arkansas 21upset | Box score |
| Oct 21, 1978 | TCU 13, Tulane 7upset | Box score |
| Oct 21, 1978 | Texas Tech 42, Rice 28 | Box score |
| Oct 21, 1978 | Texas–Arlington 37, Lamar 17 | Box score |
| Oct 21, 1978 | Toledo 28, Ohio 14upset | Box score |
| Oct 21, 1978 | Tulsa 27, Cincinnati 26 | Box score |
| Oct 21, 1978 | 10UCLA 45, California 0 | Box score |
| Oct 21, 1978 | Virginia 17, Virginia Tech 7upset | Box score |
| Oct 21, 1978 | Washington 20, Oregon 14 | Box score |
| Oct 21, 1978 | West Texas 36, Indiana State 7 | Box score |
| Oct 21, 1978 | Western Michigan 32, Eastern Michigan 0 | Box score |
| Oct 21, 1978 | Wichita State 33, Southern Illinois 7 | Box score |
| Oct 21, 1978 | Wyoming 34, Utah 21 | Box score |