| Oct 14, 1978 | 7Alabama 23, Florida 12 | Box score |
| Oct 14, 1978 | Arizona State 20, 2USC 7upset | Box score |
| Oct 14, 1978 | Arkansas State 26, Southern Illinois 24 | Box score |
| Oct 14, 1978 | Auburn 49, Vanderbilt 7 | Box score |
| Oct 14, 1978 | Bowling Green 28, Kent State 20 | Box score |
| Oct 14, 1978 | BYU 17, Oregon 16 | Box score |
| Oct 14, 1978 | Brown 14, Pennsylvania 0 | Box score |
| Oct 14, 1978 | California 33, Arizona 20 | Box score |
| Oct 14, 1978 | Central Michigan 45, Illinois State 7 | Box score |
| Oct 14, 1978 | Clemson 30, Virginia 14 | Box score |
| Oct 14, 1978 | Colgate 20, Villanova 14upset | Box score |
| Oct 14, 1978 | Colorado State 31, Air Force 13 | Box score |
| Oct 14, 1978 | Columbia 14, Princeton 10 | Box score |
| Oct 14, 1978 | Cornell 25, Harvard 20upset | Box score |
| Oct 14, 1978 | Dartmouth 10, Yale 3 | Box score |
| Oct 14, 1978 | Georgia 24, 11LSU 17upset | Box score |
| Oct 14, 1978 | Georgia Tech 24, Miami 19 | Box score |
| Oct 14, 1978 | Holy Cross 31, Army 0 | Box score |
| Oct 14, 1978 | 17Houston 33, 6Texas A&M 0upset | Box score |
| Oct 14, 1978 | Indiana 38, Northwestern 10 | Box score |
| Oct 14, 1978 | Indiana State 13, Drake 0 | Box score |
| Oct 14, 1978 | Kentucky 24, Ole Miss 17 | Box score |
| Oct 14, 1978 | Long Beach State 33, Utah State 17upset | Box score |
| Oct 14, 1978 | Louisiana Tech 17, Ball State 7 | Box score |
| Oct 14, 1978 | 10Maryland 24, Syracuse 9 | Box score |
| Oct 14, 1978 | McNeese 31, UL Monroe 10 | Box score |
| Oct 14, 1978 | Memphis 26, Wichita State 13 | Box score |
| Oct 14, 1978 | Miami (OH) 29, Marshall 3 | Box score |
| Oct 14, 1978 | Michigan State 24, 5Michigan 15upset | Box score |
| Oct 14, 1978 | Minnesota 22, Iowa 20 | Box score |
| Oct 14, 1978 | Mississippi State 55, 15Florida State 27upset | Box score |
| Oct 14, 1978 | 19Missouri 26, 20Iowa State 13 | Box score |
| Oct 14, 1978 | Navy 31, Duke 8 | Box score |
| Oct 14, 1978 | 8Nebraska 48, Kansas State 14 | Box score |
| Oct 14, 1978 | UNLV 30, Hawai’i 20upset | Box score |
| Oct 14, 1978 | New Mexico State 23, Tulsa 20 | Box score |
| Oct 14, 1978 | North Carolina 34, Wake Forest 29 | Box score |
| Oct 14, 1978 | Notre Dame 26, 9Pittsburgh 17upset | Box score |
| Oct 14, 1978 | 1Oklahoma 17, Kansas 16 | Box score |
| Oct 14, 1978 | Oklahoma State 24, 13Colorado 20upset | Box score |
| Oct 14, 1978 | Pacific 27, Fresno State 7 | Box score |
| Oct 14, 1978 | Purdue 27, 16Ohio State 16upset | Box score |
| Oct 14, 1978 | Rice 21, TCU 14 | Box score |
| Oct 14, 1978 | South Carolina 24, Ohio 7 | Box score |
| Oct 14, 1978 | SMU 28, Baylor 21 | Box score |
| Oct 14, 1978 | Southern Miss 17, East Carolina 16 | Box score |
| Oct 14, 1978 | Temple 16, Cincinnati 13 | Box score |
| Oct 14, 1978 | 12Texas 26, North Texas 16 | Box score |
| Oct 14, 1978 | Texas Tech 36, New Mexico 23 | Box score |
| Oct 14, 1978 | Texas–Arlington 24, Louisiana 3 | Box score |
| Oct 14, 1978 | Tulane 9, Boston College 3 | Box score |
| Oct 14, 1978 | 14UCLA 45, Washington State 31 | Box score |
| Oct 14, 1978 | VMI 23, Richmond 6 | Box score |
| Oct 14, 1978 | Virginia Tech 16, West Virginia 3 | Box score |
| Oct 14, 1978 | Washington 34, 18Stanford 31upset | Box score |
| Oct 14, 1978 | West Texas 55, Lamar 16 | Box score |
| Oct 14, 1978 | Western Carolina 38, The Citadel 24 | Box score |
| Oct 14, 1978 | Western Michigan 17, Toledo 7 | Box score |
| Oct 14, 1978 | Illinois 20, Wisconsin 20 | Box score |
| Oct 14, 1978 | Wyoming 31, San Diego State 22upset | Box score |