| Oct 7, 1978 | 8Alabama 20, Washington 17 | Box score |
| Oct 7, 1978 | Arizona State 56, Northwestern 14 | Box score |
| Oct 7, 1978 | 4Arkansas 42, TCU 3 | Box score |
| Oct 7, 1978 | Ball State 7, Indiana State 0 | Box score |
| Oct 7, 1978 | Bowling Green 45, Toledo 27 | Box score |
| Oct 7, 1978 | Brown 44, Princeton 16 | Box score |
| Oct 7, 1978 | California 21, Oregon 18 | Box score |
| Oct 7, 1978 | Central Michigan 17, Ohio 3 | Box score |
| Oct 7, 1978 | Chattanooga 72, App State 14 | Box score |
| Oct 7, 1978 | The Citadel 41, Marshall 0 | Box score |
| Oct 7, 1978 | Clemson 38, Virginia Tech 7 | Box score |
| Oct 7, 1978 | 13Colorado 17, Kansas 7 | Box score |
| Oct 7, 1978 | Colorado State 39, UTEP 29 | Box score |
| Oct 7, 1978 | Drake 48, Wichita State 22 | Box score |
| Oct 7, 1978 | Duke 20, Virginia 13 | Box score |
| Oct 7, 1978 | East Carolina 19, VMI 6 | Box score |
| Oct 7, 1978 | 18Florida State 26, Cincinnati 21 | Box score |
| Oct 7, 1978 | Georgia 42, Ole Miss 3 | Box score |
| Oct 7, 1978 | Georgia Tech 6, South Carolina 3 | Box score |
| Oct 7, 1978 | Harvard 24, Colgate 21 | Box score |
| Oct 7, 1978 | Hawai’i 25, San José State 11 | Box score |
| Oct 7, 1978 | Houston 20, Baylor 18 | Box score |
| Oct 7, 1978 | Kansas State 18, Oklahoma State 7 | Box score |
| Oct 7, 1978 | Long Beach State 24, Northern Illinois 19 | Box score |
| Oct 7, 1978 | Louisiana 24, Louisiana Tech 6 | Box score |
| Oct 7, 1978 | 11LSU 34, Florida 21 | Box score |
| Oct 7, 1978 | Lamar 17, UL Monroe 17 | Box score |
| Oct 7, 1978 | 12Maryland 31, 20NC State 7 | Box score |
| Oct 7, 1978 | Miami 17, 19Auburn 15upset | Box score |
| Oct 7, 1978 | Miami (OH) 7, North Carolina 3upset | Box score |
| Oct 7, 1978 | 3Michigan 21, Arizona 17 | Box score |
| Oct 7, 1978 | Missouri 45, Illinois 3 | Box score |
| Oct 7, 1978 | Navy 37, Air Force 8 | Box score |
| Oct 7, 1978 | 10Nebraska 23, 15Iowa State 0 | Box score |
| Oct 7, 1978 | New Mexico 19, Wyoming 15 | Box score |
| Oct 7, 1978 | North Texas 35, West Texas 0 | Box score |
| Oct 7, 1978 | Notre Dame 29, Michigan State 25 | Box score |
| Oct 7, 1978 | 1Oklahoma 31, 6Texas 10 | Box score |
| Oct 7, 1978 | Oregon State 17, Minnesota 14upset | Box score |
| Oct 7, 1978 | Pacific 35, Cal State Fullerton 17 | Box score |
| Oct 7, 1978 | 5Penn State 30, Kentucky 0 | Box score |
| Oct 7, 1978 | Pennsylvania 31, Columbia 19 | Box score |
| Oct 7, 1978 | 9Pittsburgh 32, Boston College 15 | Box score |
| Oct 7, 1978 | Purdue 14, Wake Forest 7 | Box score |
| Oct 7, 1978 | Rutgers 28, Yale 27upset | Box score |
| Oct 7, 1978 | San Diego State 31, Fresno State 14 | Box score |
| Oct 7, 1978 | Southern Illinois 26, Illinois State 0 | Box score |
| Oct 7, 1978 | 14Ohio State 35, SMU 35 | Box score |
| Oct 7, 1978 | Southern Miss 22, Mississippi State 17 | Box score |
| Oct 7, 1978 | Syracuse 31, West Virginia 15 | Box score |
| Oct 7, 1978 | William & Mary 22, Temple 22 | Box score |
| Oct 7, 1978 | Tennessee 31, Army 13 | Box score |
| Oct 7, 1978 | 7Texas A&M 38, Texas Tech 9 | Box score |
| Oct 7, 1978 | Texas–Arlington 28, New Mexico State 17 | Box score |
| Oct 7, 1978 | Tulane 38, Vanderbilt 3 | Box score |
| Oct 7, 1978 | Tulsa 24, Louisville 7 | Box score |
| Oct 7, 1978 | 16UCLA 27, 17Stanford 26 | Box score |
| Oct 7, 1978 | Utah 13, Iowa 9 | Box score |
| Oct 7, 1978 | Utah State 24, BYU 7upset | Box score |
| Oct 7, 1978 | Villanova 17, Richmond 14 | Box score |
| Oct 7, 1978 | Western Michigan 14, Kent State 0 | Box score |
| Oct 7, 1978 | Wisconsin 34, Indiana 7 | Box score |