| Sep 29, 1978 | 3USC 30, Michigan State 9 | Box score |
| Sep 30, 1978 | 7Alabama 51, Vanderbilt 28 | Box score |
| Sep 30, 1978 | Arizona 23, Iowa 3 | Box score |
| Sep 30, 1978 | Arizona State 27, UTEP 0 | Box score |
| Sep 30, 1978 | 2Arkansas 21, Tulsa 13 | Box score |
| Sep 30, 1978 | Auburn 29, Tennessee 10 | Box score |
| Sep 30, 1978 | Ball State 27, Central Michigan 0 | Box score |
| Sep 30, 1978 | BYU 27, New Mexico 23 | Box score |
| Sep 30, 1978 | California 28, West Virginia 21 | Box score |
| Sep 30, 1978 | Clemson 31, Villanova 0 | Box score |
| Sep 30, 1978 | 16Colorado 55, Northwestern 7 | Box score |
| Sep 30, 1978 | Cornell 21, Colgate 12upset | Box score |
| Sep 30, 1978 | East Carolina 23, Texas–Arlington 17 | Box score |
| Sep 30, 1978 | Eastern Michigan 17, Toledo 12 | Box score |
| Sep 30, 1978 | Florida 34, Mississippi State 0 | Box score |
| Sep 30, 1978 | Furman 52, App State 34 | Box score |
| Sep 30, 1978 | Georgia Tech 28, The Citadel 0 | Box score |
| Sep 30, 1978 | Hawai’i 42, Cal State Fullerton 33 | Box score |
| Sep 30, 1978 | Holy Cross 35, Dartmouth 0 | Box score |
| Sep 30, 1978 | Houston 27, 10Florida State 21upset | Box score |
| Sep 30, 1978 | Illinois 28, Syracuse 14upset | Box score |
| Sep 30, 1978 | 17Iowa State 35, Drake 7 | Box score |
| Sep 30, 1978 | Kansas State 34, Air Force 21 | Box score |
| Sep 30, 1978 | Kent State 20, Ohio 14 | Box score |
| Sep 30, 1978 | Louisiana 23, Lamar 16 | Box score |
| Sep 30, 1978 | 11LSU 37, Rice 7 | Box score |
| Sep 30, 1978 | Louisiana Tech 34, McNeese 20 | Box score |
| Sep 30, 1978 | Louisville 31, Indiana State 12 | Box score |
| Sep 30, 1978 | 15Maryland 20, Kentucky 3 | Box score |
| Sep 30, 1978 | Miami 38, Kansas 6 | Box score |
| Sep 30, 1978 | 4Michigan 52, Duke 0 | Box score |
| Sep 30, 1978 | Ole Miss 16, Southern Miss 13 | Box score |
| Sep 30, 1978 | Navy 19, Boston College 8 | Box score |
| Sep 30, 1978 | 12Nebraska 69, Indiana 17 | Box score |
| Sep 30, 1978 | NC State 34, Wake Forest 10 | Box score |
| Sep 30, 1978 | North Texas 12, Oklahoma State 7 | Box score |
| Sep 30, 1978 | Northern Illinois 49, Illinois State 21 | Box score |
| Sep 30, 1978 | Notre Dame 10, Purdue 6 | Box score |
| Sep 30, 1978 | 13Ohio State 34, Baylor 28 | Box score |
| Sep 30, 1978 | 1Oklahoma 45, 14Missouri 23 | Box score |
| Sep 30, 1978 | Pacific 14, Long Beach State 0 | Box score |
| Sep 30, 1978 | 5Penn State 58, TCU 0 | Box score |
| Sep 30, 1978 | 9Pittsburgh 20, North Carolina 16 | Box score |
| Sep 30, 1978 | Richmond 51, Cincinnati 28 | Box score |
| Sep 30, 1978 | Rutgers 24, Princeton 0 | Box score |
| Sep 30, 1978 | South Carolina 27, 19Georgia 10upset | Box score |
| Sep 30, 1978 | Southern Illinois 43, New Mexico State 39 | Box score |
| Sep 30, 1978 | 20Stanford 17, Tulane 14 | Box score |
| Sep 30, 1978 | 6Texas 24, Texas Tech 7 | Box score |
| Sep 30, 1978 | 8Texas A&M 58, Memphis 0 | Box score |
| Sep 30, 1978 | 18UCLA 17, Minnesota 3 | Box score |
| Sep 30, 1978 | Utah 30, Colorado State 6 | Box score |
| Sep 30, 1978 | Utah State 20, Wyoming 13 | Box score |
| Sep 30, 1978 | VMI 17, Virginia 9 | Box score |
| Sep 30, 1978 | Virginia Tech 22, William & Mary 19 | Box score |
| Sep 30, 1978 | Washington 34, Oregon State 0 | Box score |
| Sep 30, 1978 | Army 21, Washington State 21 | Box score |
| Sep 30, 1978 | Western Carolina 21, Marshall 14 | Box score |
| Sep 30, 1978 | Western Michigan 24, Bowling Green 20 | Box score |
| Sep 30, 1978 | Wichita State 38, West Texas 37 | Box score |
| Sep 30, 1978 | Wisconsin 22, Oregon 19 | Box score |