| Sep 23, 1978 | App State 24, Richmond 19 | Box score |
| Sep 23, 1978 | 2Arkansas 19, Oklahoma State 7 | Box score |
| Sep 23, 1978 | Arkansas State 10, Drake 0 | Box score |
| Sep 23, 1978 | Auburn 18, Virginia Tech 7 | Box score |
| Sep 23, 1978 | Ball State 20, Toledo 0 | Box score |
| Sep 23, 1978 | BYU 32, Colorado State 6 | Box score |
| Sep 23, 1978 | California 24, Pacific 6 | Box score |
| Sep 23, 1978 | Chattanooga 27, Marshall 23 | Box score |
| Sep 23, 1978 | The Citadel 14, VMI 3 | Box score |
| Sep 23, 1978 | 19Colorado 22, San José State 7 | Box score |
| Sep 23, 1978 | Columbia 21, Harvard 19upset | Box score |
| Sep 23, 1978 | Dartmouth 31, Pennsylvania 21 | Box score |
| Sep 23, 1978 | Duke 16, South Carolina 12 | Box score |
| Sep 23, 1978 | East Carolina 38, Louisiana 9 | Box score |
| Sep 23, 1978 | Eastern Michigan 27, Indiana State 8 | Box score |
| Sep 23, 1978 | 13Florida State 31, Miami 21 | Box score |
| Sep 23, 1978 | Georgia 12, Clemson 0 | Box score |
| Sep 23, 1978 | Georgia Tech 27, Tulane 17 | Box score |
| Sep 23, 1978 | Holy Cross 35, Air Force 18 | Box score |
| Sep 23, 1978 | Houston 42, Utah 25 | Box score |
| Sep 23, 1978 | Indiana 14, 15Washington 7upset | Box score |
| Sep 23, 1978 | 20Iowa State 31, Iowa 0 | Box score |
| Sep 23, 1978 | Kansas 28, 8UCLA 24upset | Box score |
| Sep 23, 1978 | Kent State 34, Illinois State 3 | Box score |
| Sep 23, 1978 | Kentucky 25, Baylor 21 | Box score |
| Sep 23, 1978 | 10LSU 13, Wake Forest 11 | Box score |
| Sep 23, 1978 | Louisiana Tech 28, Texas–Arlington 21 | Box score |
| Sep 23, 1978 | UL Monroe 27, Northern Illinois 10 | Box score |
| Sep 23, 1978 | Louisville 28, Cincinnati 14upset | Box score |
| Sep 23, 1978 | 18Maryland 21, North Carolina 20 | Box score |
| Sep 23, 1978 | Miami (OH) 7, Western Michigan 3 | Box score |
| Sep 23, 1978 | 5Michigan 28, 14Notre Dame 14 | Box score |
| Sep 23, 1978 | Michigan State 49, Syracuse 21 | Box score |
| Sep 23, 1978 | Mississippi State 44, Memphis 14 | Box score |
| Sep 23, 1978 | 17Missouri 45, Ole Miss 14 | Box score |
| Sep 23, 1978 | New Mexico 24, UNLV 0 | Box score |
| Sep 23, 1978 | NC State 29, West Virginia 15 | Box score |
| Sep 23, 1978 | North Texas 22, New Mexico State 21 | Box score |
| Sep 23, 1978 | 16Ohio State 27, Minnesota 10 | Box score |
| Sep 23, 1978 | 3Oklahoma 66, Rice 7 | Box score |
| Sep 23, 1978 | Tennessee 13, Oregon State 13 | Box score |
| Sep 23, 1978 | 3Penn State 26, SMU 21 | Box score |
| Sep 23, 1978 | 11Pittsburgh 20, Temple 12 | Box score |
| Sep 23, 1978 | Cornell 14, Princeton 14 | Box score |
| Sep 23, 1978 | Purdue 24, Ohio 0 | Box score |
| Sep 23, 1978 | 7USC 24, 1Alabama 14upset | Box score |
| Sep 23, 1978 | Southern Illinois 17, West Texas 3 | Box score |
| Sep 23, 1978 | Stanford 35, Illinois 10 | Box score |
| Sep 23, 1978 | 6Texas 17, Wyoming 3 | Box score |
| Sep 23, 1978 | 9Texas A&M 37, Boston College 2 | Box score |
| Sep 23, 1978 | TCU 14, Oregon 10 | Box score |
| Sep 23, 1978 | Texas Tech 41, Arizona 26 | Box score |
| Sep 23, 1978 | UTEP 31, San Diego State 24upset | Box score |
| Sep 23, 1978 | Tulsa 24, Kansas State 14 | Box score |
| Sep 23, 1978 | Utah State 45, Fresno State 22 | Box score |
| Sep 23, 1978 | Vanderbilt 17, Furman 10 | Box score |
| Sep 23, 1978 | Virginia 21, Army 17upset | Box score |
| Sep 23, 1978 | Washington State 51, Arizona State 26 | Box score |
| Sep 23, 1978 | William & Mary 21, Villanova 17 | Box score |
| Sep 23, 1978 | Wisconsin 28, Northwestern 7 | Box score |
| Sep 23, 1978 | Yale 21, Brown 0 | Box score |