| Sep 16, 1978 | Air Force 18, Boston College 7upset | Box score |
| Sep 16, 1978 | 1Alabama 38, 11Missouri 20 | Box score |
| Sep 16, 1978 | App State 28, Marshall 7 | Box score |
| Sep 16, 1978 | Arizona 21, Oregon State 7 | Box score |
| Sep 16, 1978 | Arizona State 24, BYU 17 | Box score |
| Sep 16, 1978 | 2Arkansas 48, Vanderbilt 17 | Box score |
| Sep 16, 1978 | Auburn 45, Kansas State 32 | Box score |
| Sep 16, 1978 | Ball State 27, Kent State 3 | Box score |
| Sep 16, 1978 | Bowling Green 43, Eastern Michigan 6 | Box score |
| Sep 16, 1978 | California 34, Georgia Tech 22 | Box score |
| Sep 16, 1978 | Central Michigan 37, Miami (OH) 18 | Box score |
| Sep 16, 1978 | Chattanooga 12, Louisiana Tech 7upset | Box score |
| Sep 16, 1978 | Cincinnati 26, Southern Miss 14 | Box score |
| Sep 16, 1978 | Clemson 58, The Citadel 3 | Box score |
| Sep 16, 1978 | Colorado 17, Miami 7 | Box score |
| Sep 16, 1978 | 16Florida State 38, Oklahoma State 20 | Box score |
| Sep 16, 1978 | Georgia 16, Baylor 14 | Box score |
| Sep 16, 1978 | Holy Cross 27, Colgate 14upset | Box score |
| Sep 16, 1978 | Iowa 20, Northwestern 3 | Box score |
| Sep 16, 1978 | 19Iowa State 14, San Diego State 13 | Box score |
| Sep 16, 1978 | South Carolina 14, 17Kentucky 14 | Box score |
| Sep 16, 1978 | 13LSU 24, Indiana 17 | Box score |
| Sep 16, 1978 | UL Monroe 21, Arkansas State 13 | Box score |
| Sep 16, 1978 | 20Maryland 24, Louisville 17 | Box score |
| Sep 16, 1978 | McNeese 45, West Texas 13upset | Box score |
| Sep 16, 1978 | Memphis 17, Houston 3 | Box score |
| Sep 16, 1978 | 4Michigan 31, Illinois 0 | Box score |
| Sep 16, 1978 | Minnesota 38, Toledo 12 | Box score |
| Sep 16, 1978 | Navy 32, Virginia 0 | Box score |
| Sep 16, 1978 | 12Nebraska 56, Hawai’i 10 | Box score |
| Sep 16, 1978 | New Mexico 16, Wichita State 14 | Box score |
| Sep 16, 1978 | New Mexico State 35, UTEP 32 | Box score |
| Sep 16, 1978 | North Carolina 14, East Carolina 10 | Box score |
| Sep 16, 1978 | NC State 27, Syracuse 19 | Box score |
| Sep 16, 1978 | North Texas 28, Texas–Arlington 23 | Box score |
| Sep 16, 1978 | 3Oklahoma 52, West Virginia 10 | Box score |
| Sep 16, 1978 | 5Penn State 19, 6Ohio State 0 | Box score |
| Sep 16, 1978 | 14Pittsburgh 24, Tulane 6 | Box score |
| Sep 16, 1978 | Purdue 21, Michigan State 14 | Box score |
| Sep 16, 1978 | 8USC 37, Oregon 10 | Box score |
| Sep 16, 1978 | Southern Illinois 22, Lamar 20 | Box score |
| Sep 16, 1978 | SMU 35, Florida 25 | Box score |
| Sep 16, 1978 | Stanford 38, San José State 9 | Box score |
| Sep 16, 1978 | Temple 36, Drake 29 | Box score |
| Sep 16, 1978 | 7Texas 34, Rice 0 | Box score |
| Sep 16, 1978 | Tulsa 10, Louisiana 3 | Box score |
| Sep 16, 1978 | 9UCLA 13, Tennessee 0 | Box score |
| Sep 16, 1978 | Utah State 21, Colorado State 20upset | Box score |
| Sep 16, 1978 | Virginia Tech 28, Wake Forest 6 | Box score |
| Sep 16, 1978 | 18Washington 31, Kansas 2 | Box score |
| Sep 16, 1978 | Western Michigan 44, Northern Illinois 30 | Box score |
| Sep 16, 1978 | Wisconsin 7, Richmond 6 | Box score |