| Nov 4, 1978 | 3Alabama 35, Mississippi State 14 | Box score |
| Nov 4, 1978 | Arizona State 35, California 21 | Box score |
| Nov 4, 1978 | 17Arkansas 37, Rice 7 | Box score |
| Nov 4, 1978 | Arkansas State 16, Louisiana 6 | Box score |
| Nov 4, 1978 | Army 28, Air Force 14 | Box score |
| Nov 4, 1978 | Ball State 39, Bowling Green 14 | Box score |
| Nov 4, 1978 | BYU 48, Wyoming 14 | Box score |
| Nov 4, 1978 | Brown 31, Harvard 30 | Box score |
| Nov 4, 1978 | Central Michigan 27, Toledo 3 | Box score |
| Nov 4, 1978 | Cincinnati 20, UL Monroe 7 | Box score |
| Nov 4, 1978 | 16Clemson 51, Wake Forest 6 | Box score |
| Nov 4, 1978 | Dartmouth 37, Columbia 7 | Box score |
| Nov 4, 1978 | East Carolina 33, App State 8 | Box score |
| Nov 4, 1978 | Florida 31, Auburn 7 | Box score |
| Nov 4, 1978 | Fresno State 42, Long Beach State 41 | Box score |
| Nov 4, 1978 | 13Georgia 41, VMI 3 | Box score |
| Nov 4, 1978 | Hawai’i 35, UTEP 13 | Box score |
| Nov 4, 1978 | 10Houston 63, TCU 6 | Box score |
| Nov 4, 1978 | Iowa State 24, Kansas State 0 | Box score |
| Nov 4, 1978 | Kentucky 28, Virginia Tech 0 | Box score |
| Nov 4, 1978 | 12LSU 30, Ole Miss 8 | Box score |
| Nov 4, 1978 | Louisiana Tech 40, Lamar 3 | Box score |
| Nov 4, 1978 | Louisville 38, Wichita State 20 | Box score |
| Nov 4, 1978 | Memphis 35, Vanderbilt 14 | Box score |
| Nov 4, 1978 | Miami (OH) 31, Ohio 16 | Box score |
| Nov 4, 1978 | 8Michigan 34, Iowa 0 | Box score |
| Nov 4, 1978 | 18Michigan State 59, Illinois 19 | Box score |
| Nov 4, 1978 | Minnesota 32, Indiana 31 | Box score |
| Nov 4, 1978 | 4Nebraska 63, Kansas 21 | Box score |
| Nov 4, 1978 | New Mexico 24, Utah 12 | Box score |
| Nov 4, 1978 | New Mexico State 21, Drake 20 | Box score |
| Nov 4, 1978 | NC State 22, South Carolina 13 | Box score |
| Nov 4, 1978 | North Texas 25, Southern Miss 12 | Box score |
| Nov 4, 1978 | Northern Illinois 27, Kent State 21 | Box score |
| Nov 4, 1978 | 15Notre Dame 27, 11Navy 7upset | Box score |
| Nov 4, 1978 | Ohio State 49, Wisconsin 14 | Box score |
| Nov 4, 1978 | 1Oklahoma 28, Colorado 7 | Box score |
| Nov 4, 1978 | Oklahoma State 35, Missouri 20 | Box score |
| Nov 4, 1978 | Oregon State 32, Washington State 31upset | Box score |
| Nov 4, 1978 | 2Penn State 27, 5Maryland 3 | Box score |
| Nov 4, 1978 | 19Pittsburgh 18, Syracuse 17 | Box score |
| Nov 4, 1978 | Princeton 21, Pennsylvania 0 | Box score |
| Nov 4, 1978 | 14Purdue 31, Northwestern 0 | Box score |
| Nov 4, 1978 | Richmond 27, North Carolina 18upset | Box score |
| Nov 4, 1978 | San Diego State 34, Colorado State 31 | Box score |
| Nov 4, 1978 | San José State 30, Cal State Fullerton 21 | Box score |
| Nov 4, 1978 | 6USC 13, Stanford 7 | Box score |
| Nov 4, 1978 | Southern Illinois 28, Indiana State 7 | Box score |
| Nov 4, 1978 | Tennessee 34, Duke 0 | Box score |
| Nov 4, 1978 | Texas A&M 20, SMU 17 | Box score |
| Nov 4, 1978 | Texas Tech 27, Baylor 9 | Box score |
| Nov 4, 1978 | Tulane 20, Miami 16 | Box score |
| Nov 4, 1978 | Tulsa 44, West Texas 23 | Box score |
| Nov 4, 1978 | 9UCLA 23, Oregon 21 | Box score |
| Nov 4, 1978 | Utah State 40, Pacific 14 | Box score |
| Nov 4, 1978 | Villanova 28, Boston College 16 | Box score |
| Nov 4, 1978 | 20Washington 31, Arizona 21 | Box score |
| Nov 4, 1978 | West Virginia 20, Virginia 17 | Box score |
| Nov 4, 1978 | Western Carolina 31, Chattanooga 21upset | Box score |
| Nov 4, 1978 | Western Michigan 24, Marshall 6 | Box score |
| Nov 4, 1978 | William & Mary 12, The Citadel 8 | Box score |
| Nov 4, 1978 | Yale 42, Cornell 14 | Box score |