| Nov 11, 1978 | 3Alabama 31, 10LSU 10 | Box score |
| Nov 11, 1978 | App State 31, VMI 10 | Box score |
| Nov 11, 1978 | Arizona 24, Oregon 3 | Box score |
| Nov 11, 1978 | 16Arkansas 27, Baylor 14 | Box score |
| Nov 11, 1978 | Army 29, Boston College 26 | Box score |
| Nov 11, 1978 | Auburn 6, Mississippi State 0upset | Box score |
| Nov 11, 1978 | Ball State 20, Western Michigan 14 | Box score |
| Nov 11, 1978 | BYU 21, San Diego State 3 | Box score |
| Nov 11, 1978 | California 22, Washington State 14 | Box score |
| Nov 11, 1978 | Central Michigan 41, Eastern Michigan 9 | Box score |
| Nov 11, 1978 | Chattanooga 30, Richmond 3 | Box score |
| Nov 11, 1978 | Cincinnati 35, Ohio 0 | Box score |
| Nov 11, 1978 | 15Clemson 13, North Carolina 9 | Box score |
| Nov 11, 1978 | Colorado State 26, New Mexico 15upset | Box score |
| Nov 11, 1978 | Cornell 35, Columbia 14 | Box score |
| Nov 11, 1978 | Dartmouth 31, Brown 21 | Box score |
| Nov 11, 1978 | Drake 24, West Texas 21 | Box score |
| Nov 11, 1978 | Duke 3, Wake Forest 0 | Box score |
| Nov 11, 1978 | East Carolina 20, William & Mary 3 | Box score |
| Nov 11, 1978 | Florida State 24, Virginia Tech 14 | Box score |
| Nov 11, 1978 | Furman 24, Western Carolina 7 | Box score |
| Nov 11, 1978 | 11Georgia 24, Florida 22 | Box score |
| Nov 11, 1978 | Georgia Tech 42, Air Force 21 | Box score |
| Nov 11, 1978 | Harvard 17, Pennsylvania 13 | Box score |
| Nov 11, 1978 | Hawai’i 35, New Mexico State 20 | Box score |
| Nov 11, 1978 | 8Houston 10, 6Texas 7upset | Box score |
| Nov 11, 1978 | Illinois State 27, Indiana State 14 | Box score |
| Nov 11, 1978 | Indiana 34, Iowa 14 | Box score |
| Nov 11, 1978 | Iowa State 28, Oklahoma State 15 | Box score |
| Nov 11, 1978 | Kansas State 20, Colorado 10upset | Box score |
| Nov 11, 1978 | Kentucky 53, Vanderbilt 2 | Box score |
| Nov 11, 1978 | Louisiana Tech 24, Arkansas State 10 | Box score |
| Nov 11, 1978 | 13Maryland 17, Virginia 7 | Box score |
| Nov 11, 1978 | McNeese 24, Lamar 23 | Box score |
| Nov 11, 1978 | Memphis 29, Louisville 22upset | Box score |
| Nov 11, 1978 | Miami (OH) 38, Kent State 13 | Box score |
| Nov 11, 1978 | 7Michigan 59, Northwestern 14 | Box score |
| Nov 11, 1978 | 17Michigan State 33, Minnesota 9 | Box score |
| Nov 11, 1978 | Ole Miss 13, Tulane 3 | Box score |
| Nov 11, 1978 | Missouri 48, Kansas 0 | Box score |
| Nov 11, 1978 | 4Nebraska 17, 1Oklahoma 14upset | Box score |
| Nov 11, 1978 | UNLV 12, Wyoming 10 | Box score |
| Nov 11, 1978 | North Texas 28, UL Monroe 6 | Box score |
| Nov 11, 1978 | 14Notre Dame 31, Tennessee 14 | Box score |
| Nov 11, 1978 | Ohio State 45, Illinois 7 | Box score |
| Nov 11, 1978 | Oregon State 15, 9UCLA 13upset | Box score |
| Nov 11, 1978 | 2Penn State 19, NC State 10 | Box score |
| Nov 11, 1978 | 20Pittsburgh 52, West Virginia 7 | Box score |
| Nov 11, 1978 | Wisconsin 24, 12Purdue 24 | Box score |
| Nov 11, 1978 | Rutgers 13, Temple 10 | Box score |
| Nov 11, 1978 | San José State 33, Pacific 31 | Box score |
| Nov 11, 1978 | 5USC 28, 19Washington 10 | Box score |
| Nov 11, 1978 | Southern Illinois 15, Marshall 14 | Box score |
| Nov 11, 1978 | SMU 58, Rice 0 | Box score |
| Nov 11, 1978 | Southern Miss 38, Bowling Green 21 | Box score |
| Nov 11, 1978 | Stanford 21, Arizona State 14 | Box score |
| Nov 11, 1978 | Syracuse 20, 18Navy 17upset | Box score |
| Nov 11, 1978 | Texas Tech 27, TCU 17 | Box score |
| Nov 11, 1978 | Toledo 35, Northern Illinois 16 | Box score |
| Nov 11, 1978 | Tulsa 27, Wichita State 13 | Box score |
| Nov 11, 1978 | Utah 38, UTEP 0 | Box score |
| Nov 11, 1978 | Yale 23, Princeton 7 | Box score |