| Nov 18, 1978 | App State 39, Western Carolina 13 | Box score |
| Nov 18, 1978 | Arizona 31, Washington State 24 | Box score |
| Nov 18, 1978 | Arizona State 44, Oregon State 22 | Box score |
| Nov 18, 1978 | 13Arkansas 26, Texas A&M 7 | Box score |
| Nov 18, 1978 | Arkansas State 6, Lamar 3 | Box score |
| Nov 18, 1978 | Ball State 31, Northern Illinois 13 | Box score |
| Nov 18, 1978 | Brown 24, Columbia 12 | Box score |
| Nov 18, 1978 | Central Michigan 35, Western Michigan 14 | Box score |
| Nov 18, 1978 | 12Clemson 28, 11Maryland 24upset | Box score |
| Nov 18, 1978 | Colorado State 50, West Virginia 14 | Box score |
| Nov 18, 1978 | Cornell 35, Pennsylvania 17 | Box score |
| Nov 18, 1978 | Dartmouth 28, Princeton 21 | Box score |
| Nov 18, 1978 | East Carolina 45, Marshall 0 | Box score |
| Nov 18, 1978 | Florida 18, Kentucky 16upset | Box score |
| Nov 18, 1978 | Florida State 38, Navy 6 | Box score |
| Nov 18, 1978 | Furman 17, The Citadel 13 | Box score |
| Nov 18, 1978 | Auburn 22, 8Georgia 22 | Box score |
| Nov 18, 1978 | Hawai’i 27, Wyoming 22 | Box score |
| Nov 18, 1978 | Illinois State 14, Eastern Michigan 13 | Box score |
| Nov 18, 1978 | Indiana State 42, Wichita State 18 | Box score |
| Nov 18, 1978 | Iowa 38, Wisconsin 24 | Box score |
| Nov 18, 1978 | Iowa State 20, Colorado 16 | Box score |
| Nov 18, 1978 | Kansas State 36, Kansas 20 | Box score |
| Nov 18, 1978 | Kent State 17, Toledo 13 | Box score |
| Nov 18, 1978 | Long Beach State 25, Drake 0 | Box score |
| Nov 18, 1978 | UL Monroe 18, Louisiana Tech 0upset | Box score |
| Nov 18, 1978 | Miami 16, San Diego State 14 | Box score |
| Nov 18, 1978 | Miami (OH) 28, Cincinnati 24 | Box score |
| Nov 18, 1978 | 7Michigan 24, 15Purdue 6 | Box score |
| Nov 18, 1978 | 16Michigan State 52, Northwestern 3 | Box score |
| Nov 18, 1978 | Minnesota 24, Illinois 6 | Box score |
| Nov 18, 1978 | Mississippi State 16, 17LSU 14upset | Box score |
| Nov 18, 1978 | Missouri 35, 2Nebraska 31upset | Box score |
| Nov 18, 1978 | UNLV 27, UTEP 0 | Box score |
| Nov 18, 1978 | New Mexico 44, Pacific 6 | Box score |
| Nov 18, 1978 | North Carolina 38, Virginia 20 | Box score |
| Nov 18, 1978 | NC State 24, Duke 10 | Box score |
| Nov 18, 1978 | North Texas 41, Memphis 24 | Box score |
| Nov 18, 1978 | 10Notre Dame 38, 20Georgia Tech 21 | Box score |
| Nov 18, 1978 | Ohio 19, Bowling Green 15upset | Box score |
| Nov 18, 1978 | 19Ohio State 21, Indiana 18 | Box score |
| Nov 18, 1978 | 4Oklahoma 62, Oklahoma State 7 | Box score |
| Nov 18, 1978 | 18Pittsburgh 35, Army 17 | Box score |
| Nov 18, 1978 | Rice 24, Baylor 10upset | Box score |
| Nov 18, 1978 | Richmond 17, William & Mary 3 | Box score |
| Nov 18, 1978 | Rutgers 31, Holy Cross 21 | Box score |
| Nov 18, 1978 | South Carolina 37, Wake Forest 14 | Box score |
| Nov 18, 1978 | 5USC 17, 14UCLA 10 | Box score |
| Nov 18, 1978 | Southern Illinois 10, Louisiana 9 | Box score |
| Nov 18, 1978 | Southern Miss 37, Louisville 3 | Box score |
| Nov 18, 1978 | Stanford 30, California 10 | Box score |
| Nov 18, 1978 | Syracuse 37, Boston College 23 | Box score |
| Nov 18, 1978 | Temple 27, Villanova 17 | Box score |
| Nov 18, 1978 | Tennessee 41, Ole Miss 17 | Box score |
| Nov 18, 1978 | Tennessee State 27, Chattanooga 23 | Box score |
| Nov 18, 1978 | 9Texas 41, TCU 0 | Box score |
| Nov 18, 1978 | Texas Tech 19, SMU 16 | Box score |
| Nov 18, 1978 | Texas–Arlington 20, McNeese 17 | Box score |
| Nov 18, 1978 | Utah 23, BYU 22upset | Box score |
| Nov 18, 1978 | Vanderbilt 41, Air Force 27 | Box score |
| Nov 18, 1978 | Virginia Tech 28, VMI 2 | Box score |
| Nov 18, 1978 | Yale 35, Harvard 28 | Box score |