| Sep 30, 1977 | 15BYU 54, New Mexico 19 | Box score |
| Sep 30, 1977 | 2USC 41, Washington State 7 | Box score |
| Oct 1, 1977 | 10Alabama 18, Georgia 10 | Box score |
| Oct 1, 1977 | App State 28, Marshall 20 | Box score |
| Oct 1, 1977 | 12Arkansas 42, TCU 6 | Box score |
| Oct 1, 1977 | Auburn 21, Ole Miss 15 | Box score |
| Oct 1, 1977 | Ball State 28, Central Michigan 12 | Box score |
| Oct 1, 1977 | Bowling Green 34, Western Michigan 14 | Box score |
| Oct 1, 1977 | Brown 10, Princeton 7 | Box score |
| Oct 1, 1977 | 17California 52, San José State 3 | Box score |
| Oct 1, 1977 | Cincinnati 17, Southern Miss 6 | Box score |
| Oct 1, 1977 | Clemson 31, Virginia Tech 13 | Box score |
| Oct 1, 1977 | Colgate 38, Harvard 21 | Box score |
| Oct 1, 1977 | 7Colorado 31, Army 0 | Box score |
| Oct 1, 1977 | Colorado State 44, Utah 3 | Box score |
| Oct 1, 1977 | Columbia 30, Pennsylvania 18 | Box score |
| Oct 1, 1977 | Duke 28, Navy 16 | Box score |
| Oct 1, 1977 | Eastern Michigan 17, Toledo 7 | Box score |
| Oct 1, 1977 | Florida State 25, Oklahoma State 17upset | Box score |
| Oct 1, 1977 | Georgia Tech 30, Air Force 3 | Box score |
| Oct 1, 1977 | Hawai’i 20, Louisiana 6upset | Box score |
| Oct 1, 1977 | 19Houston 28, Baylor 24 | Box score |
| Oct 1, 1977 | Illinois State 16, Northern Illinois 7 | Box score |
| Oct 1, 1977 | Kent State 44, Ohio 23 | Box score |
| Oct 1, 1977 | Kentucky 24, 4Penn State 20upset | Box score |
| Oct 1, 1977 | Long Beach State 27, Drake 10 | Box score |
| Oct 1, 1977 | LSU 36, 9Florida 14upset | Box score |
| Oct 1, 1977 | Louisiana Tech 14, McNeese 7 | Box score |
| Oct 1, 1977 | Louisville 14, Memphis 13upset | Box score |
| Oct 1, 1977 | Miami 24, Pacific 3 | Box score |
| Oct 1, 1977 | Miami (OH) 28, Yale 14upset | Box score |
| Oct 1, 1977 | 3Michigan 41, 5Texas A&M 3 | Box score |
| Oct 1, 1977 | Minnesota 19, Washington 17 | Box score |
| Oct 1, 1977 | 18Mississippi State 24, Kansas State 21 | Box score |
| Oct 1, 1977 | Missouri 15, 20Arizona State 0upset | Box score |
| Oct 1, 1977 | 11Nebraska 31, Indiana 13 | Box score |
| Oct 1, 1977 | NC State 24, Maryland 20 | Box score |
| Oct 1, 1977 | North Texas 47, Richmond 14 | Box score |
| Oct 1, 1977 | 14Notre Dame 16, Michigan State 6 | Box score |
| Oct 1, 1977 | 6Ohio State 35, SMU 7 | Box score |
| Oct 1, 1977 | 1Oklahoma 24, Kansas 9 | Box score |
| Oct 1, 1977 | 16Pittsburgh 45, Boston College 7 | Box score |
| Oct 1, 1977 | Purdue 26, Wake Forest 17 | Box score |
| Oct 1, 1977 | Rutgers 30, Cornell 14 | Box score |
| Oct 1, 1977 | San Diego State 19, Utah State 0 | Box score |
| Oct 1, 1977 | South Carolina 19, East Carolina 16 | Box score |
| Oct 1, 1977 | Southern Illinois 9, Lamar 5 | Box score |
| Oct 1, 1977 | Stanford 20, Oregon 10 | Box score |
| Oct 1, 1977 | Syracuse 30, Illinois 20upset | Box score |
| Oct 1, 1977 | Tennessee 41, Oregon State 10 | Box score |
| Oct 1, 1977 | 8Texas 72, Rice 15 | Box score |
| Oct 1, 1977 | 13Texas Tech 10, North Carolina 7 | Box score |
| Oct 1, 1977 | Texas–Arlington 17, West Texas 13 | Box score |
| Oct 1, 1977 | UTEP 23, New Mexico State 21upset | Box score |
| Oct 1, 1977 | Tulane 36, Vanderbilt 7 | Box score |
| Oct 1, 1977 | UCLA 34, Iowa 16 | Box score |
| Oct 1, 1977 | West Virginia 13, Virginia 0 | Box score |
| Oct 1, 1977 | Furman 24, Western Carolina 24 | Box score |
| Oct 1, 1977 | Wichita State 38, Tulsa 26upset | Box score |
| Oct 1, 1977 | William & Mary 28, Villanova 8 | Box score |
| Oct 1, 1977 | Wisconsin 19, Northwestern 7 | Box score |
| Oct 1, 1977 | Wyoming 13, Arizona 12 | Box score |