| Oct 8, 1977 | 7Alabama 21, 1USC 20upset | Box score |
| Oct 8, 1977 | Arizona State 45, New Mexico 24 | Box score |
| Oct 8, 1977 | Arkansas State 10, Lamar 6 | Box score |
| Oct 8, 1977 | Army 34, Villanova 32 | Box score |
| Oct 8, 1977 | Ball State 27, Illinois State 16 | Box score |
| Oct 8, 1977 | Baylor 9, SMU 6 | Box score |
| Oct 8, 1977 | Boston College 30, Tulane 28 | Box score |
| Oct 8, 1977 | Bowling Green 21, Toledo 13 | Box score |
| Oct 8, 1977 | Cal State Fullerton 31, UL Monroe 10 | Box score |
| Oct 8, 1977 | Central Michigan 25, Northern Illinois 21 | Box score |
| Oct 8, 1977 | Chattanooga 21, Western Carolina 10 | Box score |
| Oct 8, 1977 | Clemson 31, Virginia 0 | Box score |
| Oct 8, 1977 | Colgate 31, Holy Cross 14 | Box score |
| Oct 8, 1977 | 6Colorado 29, Oklahoma State 13 | Box score |
| Oct 8, 1977 | Colorado State 31, UTEP 14 | Box score |
| Oct 8, 1977 | Dartmouth 3, Yale 0 | Box score |
| Oct 8, 1977 | Duke 25, South Carolina 21 | Box score |
| Oct 8, 1977 | East Carolina 33, Southern Illinois 0 | Box score |
| Oct 8, 1977 | Eastern Michigan 31, Ohio 14 | Box score |
| Oct 8, 1977 | Florida State 14, Cincinnati 0 | Box score |
| Oct 8, 1977 | Fresno State 34, San Diego State 14upset | Box score |
| Oct 8, 1977 | Georgia 14, Ole Miss 13 | Box score |
| Oct 8, 1977 | Georgia Tech 24, Tennessee 8upset | Box score |
| Oct 8, 1977 | Harvard 17, Cornell 7 | Box score |
| Oct 8, 1977 | Indiana 28, Northwestern 3 | Box score |
| Oct 8, 1977 | Indiana State 23, Drake 20 | Box score |
| Oct 8, 1977 | Iowa 18, Minnesota 6 | Box score |
| Oct 8, 1977 | Iowa State 7, Missouri 0 | Box score |
| Oct 8, 1977 | Kent State 20, Western Michigan 16 | Box score |
| Oct 8, 1977 | 16Kentucky 23, Mississippi State 7 | Box score |
| Oct 8, 1977 | Louisiana 21, Louisiana Tech 21 | Box score |
| Oct 8, 1977 | 18LSU 28, Vanderbilt 15 | Box score |
| Oct 8, 1977 | Louisville 33, Tulsa 0 | Box score |
| Oct 8, 1977 | Maryland 24, Syracuse 10 | Box score |
| Oct 8, 1977 | Miami 14, Kansas 7 | Box score |
| Oct 8, 1977 | Miami (OH) 29, Marshall 19 | Box score |
| Oct 8, 1977 | 3Michigan 24, Michigan State 14 | Box score |
| Oct 8, 1977 | Navy 10, Air Force 7 | Box score |
| Oct 8, 1977 | 9Nebraska 26, Kansas State 9 | Box score |
| Oct 8, 1977 | North Carolina 24, Wake Forest 3 | Box score |
| Oct 8, 1977 | NC State 17, Auburn 15 | Box score |
| Oct 8, 1977 | North Texas 27, Southern Miss 14 | Box score |
| Oct 8, 1977 | 4Ohio State 46, Purdue 0 | Box score |
| Oct 8, 1977 | Oregon State 24, 13BYU 19upset | Box score |
| Oct 8, 1977 | Pacific 37, Hawai’i 7 | Box score |
| Oct 8, 1977 | 10Penn State 16, Utah State 7 | Box score |
| Oct 8, 1977 | Pennsylvania 14, Brown 7upset | Box score |
| Oct 8, 1977 | 20Florida 17, 15Pittsburgh 17 | Box score |
| Oct 8, 1977 | Princeton 28, Columbia 7 | Box score |
| Oct 8, 1977 | Stanford 32, UCLA 28 | Box score |
| Oct 8, 1977 | Tennessee State 26, Grambling 8 | Box score |
| Oct 8, 1977 | 5Texas 13, 2Oklahoma 6upset | Box score |
| Oct 8, 1977 | TCU 35, Rice 15upset | Box score |
| Oct 8, 1977 | Texas Southern 37, Alcorn State 14 | Box score |
| Oct 8, 1977 | 17Texas Tech 32, Arizona 26 | Box score |
| Oct 8, 1977 | Texas–Arlington 24, McNeese 7 | Box score |
| Oct 8, 1977 | Utah 23, Wyoming 13 | Box score |
| Oct 8, 1977 | VMI 25, Richmond 0 | Box score |
| Oct 8, 1977 | Virginia Tech 17, William & Mary 8 | Box score |
| Oct 8, 1977 | Washington 54, Oregon 0 | Box score |
| Oct 8, 1977 | Washington State 17, 14California 10upset | Box score |
| Oct 8, 1977 | West Texas 17, New Mexico State 14 | Box score |
| Oct 8, 1977 | West Virginia 38, Temple 16 | Box score |
| Oct 8, 1977 | 19Wisconsin 26, Illinois 0 | Box score |