| Sep 21, 1977 | Richmond 21, App State 13 | Box score |
| Sep 24, 1977 | Air Force 15, Pacific 13 | Box score |
| Sep 24, 1977 | 10Alabama 24, Vanderbilt 12 | Box score |
| Sep 24, 1977 | Arizona 41, Iowa 7 | Box score |
| Sep 24, 1977 | Arizona State 33, Oregon State 31 | Box score |
| Sep 24, 1977 | 16Arkansas 37, Tulsa 3 | Box score |
| Sep 24, 1977 | Arkansas State 21, Southern Illinois 6 | Box score |
| Sep 24, 1977 | Auburn 14, Tennessee 12upset | Box score |
| Sep 24, 1977 | Boston College 49, Army 28 | Box score |
| Sep 24, 1977 | 20BYU 65, Utah State 6 | Box score |
| Sep 24, 1977 | California 28, Missouri 21 | Box score |
| Sep 24, 1977 | Central Michigan 31, Ohio 14 | Box score |
| Sep 24, 1977 | Cincinnati 63, UL Monroe 0 | Box score |
| Sep 24, 1977 | Clemson 31, Georgia Tech 14 | Box score |
| Sep 24, 1977 | Colgate 28, Cornell 22 | Box score |
| Sep 24, 1977 | 8Colorado 42, New Mexico 7 | Box score |
| Sep 24, 1977 | Dartmouth 17, Holy Cross 14 | Box score |
| Sep 24, 1977 | Duke 31, Virginia 7 | Box score |
| Sep 24, 1977 | East Carolina 14, VMI 13 | Box score |
| Sep 24, 1977 | Eastern Michigan 9, McNeese 7upset | Box score |
| Sep 24, 1977 | 13Florida 24, 12Mississippi State 22upset | Box score |
| Sep 24, 1977 | Furman 17, Chattanooga 7 | Box score |
| Sep 24, 1977 | Georgia 15, South Carolina 13 | Box score |
| Sep 24, 1977 | Hawai’i 45, Idaho 26 | Box score |
| Sep 24, 1977 | 19Houston 34, Utah 16 | Box score |
| Sep 24, 1977 | Iowa State 35, Bowling Green 21 | Box score |
| Sep 24, 1977 | Kansas 14, 15Washington State 12upset | Box score |
| Sep 24, 1977 | Kansas State 21, Wichita State 14 | Box score |
| Sep 24, 1977 | Kent State 13, Ball State 12 | Box score |
| Sep 24, 1977 | Kentucky 28, 17West Virginia 13upset | Box score |
| Sep 24, 1977 | Long Beach State 21, Lamar 7 | Box score |
| Sep 24, 1977 | Louisiana 30, Texas–Arlington 20 | Box score |
| Sep 24, 1977 | LSU 77, Rice 0 | Box score |
| Sep 24, 1977 | Illinois State 21, Louisiana Tech 21 | Box score |
| Sep 24, 1977 | Marshall 24, Toledo 0 | Box score |
| Sep 24, 1977 | Memphis 21, Virginia Tech 20 | Box score |
| Sep 24, 1977 | Miami 23, Florida State 17upset | Box score |
| Sep 24, 1977 | Miami (OH) 21, Indiana 20 | Box score |
| Sep 24, 1977 | 1Michigan 14, Navy 7 | Box score |
| Sep 24, 1977 | Michigan State 34, Wyoming 16 | Box score |
| Sep 24, 1977 | Minnesota 27, 18UCLA 13upset | Box score |
| Sep 24, 1977 | 14Nebraska 31, Baylor 10 | Box score |
| Sep 24, 1977 | New Mexico State 35, Drake 9 | Box score |
| Sep 24, 1977 | North Carolina 41, Northwestern 7 | Box score |
| Sep 24, 1977 | NC State 41, Wake Forest 14 | Box score |
| Sep 24, 1977 | North Texas 31, West Texas 20 | Box score |
| Sep 24, 1977 | 11Notre Dame 31, Purdue 24 | Box score |
| Sep 24, 1977 | 3Oklahoma 29, 4Ohio State 28 | Box score |
| Sep 24, 1977 | Oklahoma State 54, UTEP 0 | Box score |
| Sep 24, 1977 | 5Penn State 27, Maryland 9 | Box score |
| Sep 24, 1977 | Pittsburgh 76, Temple 0 | Box score |
| Sep 24, 1977 | Rutgers 10, Princeton 6 | Box score |
| Sep 24, 1977 | San José State 23, Cal State Fullerton 12 | Box score |
| Sep 24, 1977 | 2USC 51, TCU 0 | Box score |
| Sep 24, 1977 | SMU 28, Tulane 23 | Box score |
| Sep 24, 1977 | Southern Miss 27, Ole Miss 19upset | Box score |
| Sep 24, 1977 | Stanford 37, Illinois 24 | Box score |
| Sep 24, 1977 | Syracuse 22, Washington 20 | Box score |
| Sep 24, 1977 | Tennessee State 23, Texas Southern 7upset | Box score |
| Sep 24, 1977 | 6Texas A&M 33, 7Texas Tech 17 | Box score |
| Sep 24, 1977 | Western Carolina 15, Indiana State 14upset | Box score |
| Sep 24, 1977 | Western Michigan 49, Northern Illinois 21 | Box score |
| Sep 24, 1977 | William & Mary 21, Louisville 7 | Box score |
| Sep 24, 1977 | Wisconsin 22, Oregon 10 | Box score |