| Sep 26, 1975 | Long Beach State 28, Pacific 12 | Box score |
| Sep 26, 1975 | 1Oklahoma 20, Miami 17 | Box score |
| Sep 27, 1975 | 11Alabama 40, Vanderbilt 7 | Box score |
| Sep 27, 1975 | 15Arizona 14, Wyoming 0 | Box score |
| Sep 27, 1975 | 13Arizona State 20, BYU 0 | Box score |
| Sep 27, 1975 | Arkansas 31, Tulsa 15 | Box score |
| Sep 27, 1975 | Arkansas State 29, Memphis 10 | Box score |
| Sep 27, 1975 | 9Michigan 14, Baylor 14 | Box score |
| Sep 27, 1975 | Bowling Green 21, Dayton 14 | Box score |
| Sep 27, 1975 | California 33, Washington State 21 | Box score |
| Sep 27, 1975 | Central Michigan 34, Toledo 27upset | Box score |
| Sep 27, 1975 | Cincinnati 46, Louisville 27 | Box score |
| Sep 27, 1975 | Colgate 24, Cornell 22 | Box score |
| Sep 27, 1975 | Colorado 52, Wichita State 0 | Box score |
| Sep 27, 1975 | Colorado State 27, New Mexico 16 | Box score |
| Sep 27, 1975 | Duke 26, Virginia 11 | Box score |
| Sep 27, 1975 | East Carolina 41, Southern Illinois 7 | Box score |
| Sep 27, 1975 | 19Florida 27, Mississippi State 10 | Box score |
| Sep 27, 1975 | Furman 30, App State 23 | Box score |
| Sep 27, 1975 | Georgia 28, South Carolina 20 | Box score |
| Sep 27, 1975 | Georgia Tech 33, Clemson 28 | Box score |
| Sep 27, 1975 | Harvard 18, Holy Cross 7 | Box score |
| Sep 27, 1975 | Indiana 31, Utah 7 | Box score |
| Sep 27, 1975 | Iowa State 10, Florida State 6 | Box score |
| Sep 27, 1975 | Kansas 20, Oregon State 0 | Box score |
| Sep 27, 1975 | Kansas State 17, Wake Forest 16 | Box score |
| Sep 27, 1975 | Louisiana 31, New Mexico State 7 | Box score |
| Sep 27, 1975 | LSU 16, Rice 13 | Box score |
| Sep 27, 1975 | Louisiana Tech 24, Lamar 10 | Box score |
| Sep 27, 1975 | UL Monroe 38, Drake 25 | Box score |
| Sep 27, 1975 | Kentucky 10, 20Maryland 10 | Box score |
| Sep 27, 1975 | Miami (OH) 35, Ball State 28 | Box score |
| Sep 27, 1975 | Michigan State 37, NC State 15 | Box score |
| Sep 27, 1975 | Minnesota 10, Oregon 7 | Box score |
| Sep 27, 1975 | Ole Miss 24, Southern Miss 8 | Box score |
| Sep 27, 1975 | 5Missouri 27, Wisconsin 21 | Box score |
| Sep 27, 1975 | 4Nebraska 56, TCU 14 | Box score |
| Sep 27, 1975 | Northern Illinois 20, Western Michigan 0 | Box score |
| Sep 27, 1975 | 7Notre Dame 31, Northwestern 7 | Box score |
| Sep 27, 1975 | Ohio 23, Kent State 21 | Box score |
| Sep 27, 1975 | 2Ohio State 32, North Carolina 7 | Box score |
| Sep 27, 1975 | 17Oklahoma State 61, North Texas 7 | Box score |
| Sep 27, 1975 | 12Penn State 30, Iowa 10 | Box score |
| Sep 27, 1975 | Pittsburgh 47, William & Mary 0 | Box score |
| Sep 27, 1975 | Princeton 10, Rutgers 7 | Box score |
| Sep 27, 1975 | San Diego State 19, Utah State 10 | Box score |
| Sep 27, 1975 | San José State 36, 18Stanford 34upset | Box score |
| Sep 27, 1975 | 3USC 19, Purdue 6 | Box score |
| Sep 27, 1975 | SMU 27, Houston 16upset | Box score |
| Sep 27, 1975 | Syracuse 31, Tulane 13upset | Box score |
| Sep 27, 1975 | 16Tennessee 21, Auburn 17 | Box score |
| Sep 27, 1975 | 6Texas 42, Texas Tech 18 | Box score |
| Sep 27, 1975 | 8Texas A&M 43, Illinois 13 | Box score |
| Sep 27, 1975 | Air Force 20, 10UCLA 20 | Box score |
| Sep 27, 1975 | Villanova 10, Army 0upset | Box score |
| Sep 27, 1975 | VMI 55, Davidson 0 | Box score |
| Sep 27, 1975 | Virginia Tech 21, Richmond 9 | Box score |
| Sep 27, 1975 | Washington 14, Navy 13 | Box score |
| Sep 27, 1975 | 14West Virginia 35, Boston College 18 | Box score |