| Oct 3, 1975 | BYU 16, New Mexico 15 | Box score |
| Oct 4, 1975 | 9Alabama 32, Ole Miss 6 | Box score |
| Oct 4, 1975 | 17Arizona 41, Northwestern 6 | Box score |
| Oct 4, 1975 | 14Arizona State 29, Idaho 3 | Box score |
| Oct 4, 1975 | Arkansas 19, TCU 8 | Box score |
| Oct 4, 1975 | Arkansas State 39, Louisiana 17 | Box score |
| Oct 4, 1975 | Boston College 41, Villanova 12 | Box score |
| Oct 4, 1975 | Bowling Green 28, Western Michigan 0 | Box score |
| Oct 4, 1975 | Brown 17, Pennsylvania 8 | Box score |
| Oct 4, 1975 | California 27, San José State 24 | Box score |
| Oct 4, 1975 | The Citadel 21, William & Mary 6 | Box score |
| Oct 4, 1975 | Colorado State 3, Wyoming 0 | Box score |
| Oct 4, 1975 | Dartmouth 28, Holy Cross 7 | Box score |
| Oct 4, 1975 | Dayton 24, Toledo 13upset | Box score |
| Oct 4, 1975 | 20Florida 34, LSU 6 | Box score |
| Oct 4, 1975 | Georgia 35, Clemson 7 | Box score |
| Oct 4, 1975 | Georgia Tech 30, Florida State 0 | Box score |
| Oct 4, 1975 | Illinois 27, Washington State 21 | Box score |
| Oct 4, 1975 | Iowa State 31, Utah 3 | Box score |
| Oct 4, 1975 | Kansas 41, Wisconsin 7 | Box score |
| Oct 4, 1975 | Long Beach State 31, Southern Illinois 24 | Box score |
| Oct 4, 1975 | Maryland 24, Syracuse 7 | Box score |
| Oct 4, 1975 | McNeese 33, Marshall 3upset | Box score |
| Oct 4, 1975 | Memphis 21, North Texas 19 | Box score |
| Oct 4, 1975 | Miami (OH) 14, Purdue 3 | Box score |
| Oct 4, 1975 | 12Michigan 31, 5Missouri 7upset | Box score |
| Oct 4, 1975 | Michigan State 10, 8Notre Dame 3upset | Box score |
| Oct 4, 1975 | Minnesota 21, Ohio 0 | Box score |
| Oct 4, 1975 | Mississippi State 7, Southern Miss 3 | Box score |
| Oct 4, 1975 | Navy 17, Air Force 0 | Box score |
| Oct 4, 1975 | 4Nebraska 31, Miami 16 | Box score |
| Oct 4, 1975 | North Carolina 31, Virginia 28 | Box score |
| Oct 4, 1975 | NC State 27, Indiana 0 | Box score |
| Oct 4, 1975 | Northern Illinois 38, Kent State 15upset | Box score |
| Oct 4, 1975 | 2Ohio State 41, 13UCLA 20 | Box score |
| Oct 4, 1975 | 1Oklahoma 21, 19Colorado 20 | Box score |
| Oct 4, 1975 | 15Oklahoma State 17, Texas Tech 16 | Box score |
| Oct 4, 1975 | Pacific 40, UTEP 10 | Box score |
| Oct 4, 1975 | 10Penn State 10, Kentucky 3 | Box score |
| Oct 4, 1975 | Pittsburgh 14, Duke 0 | Box score |
| Oct 4, 1975 | Princeton 27, Columbia 7 | Box score |
| Oct 4, 1975 | Richmond 17, East Carolina 14upset | Box score |
| Oct 4, 1975 | Rutgers 7, Hawai’i 3 | Box score |
| Oct 4, 1975 | San Diego State 59, Cal State Fullerton 14 | Box score |
| Oct 4, 1975 | South Carolina 24, 18Baylor 13upset | Box score |
| Oct 4, 1975 | 3USC 27, Iowa 16 | Box score |
| Oct 4, 1975 | Stanford 67, Army 14 | Box score |
| Oct 4, 1975 | Temple 21, Cincinnati 17 | Box score |
| Oct 4, 1975 | 7Texas 61, Utah State 7 | Box score |
| Oct 4, 1975 | 6Texas A&M 10, Kansas State 0 | Box score |
| Oct 4, 1975 | Texas–Arlington 39, West Texas 7upset | Box score |
| Oct 4, 1975 | Tulsa 35, New Mexico State 7 | Box score |
| Oct 4, 1975 | Vanderbilt 6, Tulane 3 | Box score |
| Oct 4, 1975 | VMI 13, Furman 10 | Box score |
| Oct 4, 1975 | Virginia Tech 23, Auburn 16upset | Box score |
| Oct 4, 1975 | Washington 27, Oregon 17 | Box score |
| Oct 4, 1975 | 11West Virginia 28, SMU 22 | Box score |
| Oct 4, 1975 | Wichita State 13, Louisville 10 | Box score |
| Oct 4, 1975 | Yale 24, Colgate 10 | Box score |