| Sep 19, 1975 | 4USC 24, Oregon State 7 | Box score |
| Sep 20, 1975 | 14Alabama 56, Clemson 0 | Box score |
| Sep 20, 1975 | App State 19, Wake Forest 17 | Box score |
| Sep 20, 1975 | 17Arizona 16, Pacific 0 | Box score |
| Sep 20, 1975 | 18Arizona State 33, TCU 10 | Box score |
| Sep 20, 1975 | Arkansas State 24, McNeese 7 | Box score |
| Sep 20, 1975 | Baylor 10, Auburn 10 | Box score |
| Sep 20, 1975 | Boston College 27, Temple 9 | Box score |
| Sep 20, 1975 | Bowling Green 16, Southern Miss 14 | Box score |
| Sep 20, 1975 | Cincinnati 13, Memphis 3 | Box score |
| Sep 20, 1975 | Colgate 16, The Citadel 0 | Box score |
| Sep 20, 1975 | Colorado 27, Wyoming 10 | Box score |
| Sep 20, 1975 | Colorado State 21, BYU 17 | Box score |
| Sep 20, 1975 | Drake 31, Louisville 7 | Box score |
| Sep 20, 1975 | East Carolina 20, William & Mary 0 | Box score |
| Sep 20, 1975 | Florida State 17, Utah State 8upset | Box score |
| Sep 20, 1975 | Georgia 28, Mississippi State 6 | Box score |
| Sep 20, 1975 | Georgia Tech 38, Miami 23 | Box score |
| Sep 20, 1975 | Iowa State 17, Air Force 12 | Box score |
| Sep 20, 1975 | Kansas 14, Kentucky 10upset | Box score |
| Sep 20, 1975 | Kansas State 32, Wichita State 0 | Box score |
| Sep 20, 1975 | Kent State 17, Virginia Tech 11 | Box score |
| Sep 20, 1975 | Long Beach State 32, Cal State Fullerton 6 | Box score |
| Sep 20, 1975 | Louisiana Tech 37, Texas–Arlington 8 | Box score |
| Sep 20, 1975 | Maryland 34, North Carolina 7 | Box score |
| Sep 20, 1975 | Michigan State 14, 19Miami (OH) 13upset | Box score |
| Sep 20, 1975 | Minnesota 38, Western Michigan 0 | Box score |
| Sep 20, 1975 | 5Missouri 30, Illinois 20 | Box score |
| Sep 20, 1975 | 6Nebraska 45, Indiana 0 | Box score |
| Sep 20, 1975 | New Mexico State 17, Lamar 14 | Box score |
| Sep 20, 1975 | NC State 8, 13Florida 7upset | Box score |
| Sep 20, 1975 | Northwestern 10, Northern Illinois 3 | Box score |
| Sep 20, 1975 | 9Notre Dame 17, Purdue 0 | Box score |
| Sep 20, 1975 | Ohio 10, Ball State 0 | Box score |
| Sep 20, 1975 | 3Ohio State 17, 7Penn State 9 | Box score |
| Sep 20, 1975 | 1Oklahoma 46, 15Pittsburgh 10 | Box score |
| Sep 20, 1975 | Oklahoma State 20, 16Arkansas 13upset | Box score |
| Sep 20, 1975 | Richmond 27, Furman 21 | Box score |
| Sep 20, 1975 | San Diego State 30, North Texas 12 | Box score |
| Sep 20, 1975 | San José State 5, Oregon 0 | Box score |
| Sep 20, 1975 | South Carolina 24, Duke 16 | Box score |
| Sep 20, 1975 | 2Michigan 19, Stanford 19 | Box score |
| Sep 20, 1975 | Syracuse 10, Iowa 7 | Box score |
| Sep 20, 1975 | 8Texas 28, Washington 10 | Box score |
| Sep 20, 1975 | 11Texas A&M 39, LSU 8 | Box score |
| Sep 20, 1975 | Texas Tech 24, New Mexico 17 | Box score |
| Sep 20, 1975 | Tulane 14, Ole Miss 3 | Box score |
| Sep 20, 1975 | Tulsa 23, West Texas 14 | Box score |
| Sep 20, 1975 | 12UCLA 34, 10Tennessee 28upset | Box score |
| Sep 20, 1975 | Vanderbilt 9, Rice 6 | Box score |
| Sep 20, 1975 | Villanova 14, Toledo 10 | Box score |
| Sep 20, 1975 | Virginia 22, VMI 21 | Box score |
| Sep 20, 1975 | Washington State 30, Utah 14 | Box score |
| Sep 20, 1975 | 20West Virginia 28, California 10 | Box score |