| Sep 12, 1975 | 4USC 35, Duke 7 | Box score |
| Sep 13, 1975 | App State 41, East Carolina 25 | Box score |
| Sep 13, 1975 | Arizona State 35, Washington 12 | Box score |
| Sep 13, 1975 | Arkansas 35, Air Force 0 | Box score |
| Sep 13, 1975 | Arkansas State 23, Idaho 6 | Box score |
| Sep 13, 1975 | Army 44, Holy Cross 7 | Box score |
| Sep 13, 1975 | Ball State 38, Toledo 28 | Box score |
| Sep 13, 1975 | Bowling Green 23, BYU 21 | Box score |
| Sep 13, 1975 | Cincinnati 19, Richmond 6 | Box score |
| Sep 13, 1975 | Colorado 34, California 27 | Box score |
| Sep 13, 1975 | 19Florida 40, SMU 14 | Box score |
| Sep 13, 1975 | Illinois 27, Iowa 12 | Box score |
| Sep 13, 1975 | Indiana 20, Minnesota 14 | Box score |
| Sep 13, 1975 | Kansas State 17, Tulsa 16upset | Box score |
| Sep 13, 1975 | Kent State 31, UL Monroe 29 | Box score |
| Sep 13, 1975 | Kentucky 27, Virginia Tech 8 | Box score |
| Sep 13, 1975 | Long Beach State 24, Northern Illinois 7 | Box score |
| Sep 13, 1975 | Louisiana 27, Southern Illinois 10 | Box score |
| Sep 13, 1975 | Louisiana Tech 21, McNeese 14 | Box score |
| Sep 13, 1975 | Memphis 31, 7Auburn 20upset | Box score |
| Sep 13, 1975 | Miami (OH) 50, Marshall 0 | Box score |
| Sep 13, 1975 | 2Michigan 23, Wisconsin 6 | Box score |
| Sep 13, 1975 | Navy 42, Virginia 14 | Box score |
| Sep 13, 1975 | 6Nebraska 10, LSU 7 | Box score |
| Sep 13, 1975 | New Mexico 29, Fresno State 0 | Box score |
| Sep 13, 1975 | New Mexico State 31, UTEP 24 | Box score |
| Sep 13, 1975 | North Texas 7, Drake 3 | Box score |
| Sep 13, 1975 | Northwestern 31, Purdue 25 | Box score |
| Sep 13, 1975 | Central Michigan 6, Ohio 6 | Box score |
| Sep 13, 1975 | 3Ohio State 21, 11Michigan State 0 | Box score |
| Sep 13, 1975 | 1Oklahoma 62, Oregon 7 | Box score |
| Sep 13, 1975 | Oklahoma State 34, Wichita State 0 | Box score |
| Sep 13, 1975 | 10Penn State 34, Stanford 14 | Box score |
| Sep 13, 1975 | Rice 24, Houston 7upset | Box score |
| Sep 13, 1975 | San Diego State 25, Oregon State 0 | Box score |
| Sep 13, 1975 | South Carolina 23, Georgia Tech 17 | Box score |
| Sep 13, 1975 | Syracuse 24, Villanova 17 | Box score |
| Sep 13, 1975 | 20Tennessee 26, 14Maryland 8upset | Box score |
| Sep 13, 1975 | 12Texas 46, Colorado State 0 | Box score |
| Sep 13, 1975 | 8Texas A&M 7, Ole Miss 0 | Box score |
| Sep 13, 1975 | Texas Tech 31, Florida State 20 | Box score |
| Sep 13, 1975 | Texas–Arlington 24, TCU 7upset | Box score |
| Sep 13, 1975 | Tulane 17, Clemson 13upset | Box score |
| Sep 13, 1975 | 16UCLA 37, Iowa State 21 | Box score |
| Sep 13, 1975 | Utah State 13, Utah 7 | Box score |
| Sep 13, 1975 | Wake Forest 30, 15NC State 22upset | Box score |
| Sep 13, 1975 | Washington State 18, Kansas 14upset | Box score |
| Sep 13, 1975 | West Texas 10, Lamar 8 | Box score |
| Sep 13, 1975 | West Virginia 50, Temple 7 | Box score |
| Sep 15, 1975 | 9Notre Dame 17, Boston College 3 | Box score |