| Oct 11, 1974 | Miami 35, Pacific 6 | Box score |
| Oct 12, 1974 | 3Alabama 8, Florida State 7 | Box score |
| Oct 12, 1974 | 12Arizona 41, Utah 8 | Box score |
| Oct 12, 1974 | 10Auburn 31, Kentucky 13 | Box score |
| Oct 12, 1974 | Ball State 38, Richmond 23upset | Box score |
| Oct 12, 1974 | Baylor 21, 14Arkansas 17upset | Box score |
| Oct 12, 1974 | Boston College 31, William & Mary 16 | Box score |
| Oct 12, 1974 | Bowling Green 26, Kent State 10 | Box score |
| Oct 12, 1974 | BYU 38, Wyoming 7 | Box score |
| Oct 12, 1974 | California 40, Oregon 10 | Box score |
| Oct 12, 1974 | Colgate 21, Holy Cross 16 | Box score |
| Oct 12, 1974 | Colorado 34, Iowa State 7 | Box score |
| Oct 12, 1974 | Duke 33, Army 14 | Box score |
| Oct 12, 1974 | East Carolina 15, Furman 12 | Box score |
| Oct 12, 1974 | Georgia 49, Ole Miss 0 | Box score |
| Oct 12, 1974 | Georgia Tech 29, North Carolina 28 | Box score |
| Oct 12, 1974 | Harvard 34, Columbia 6 | Box score |
| Oct 12, 1974 | Illinois 27, Purdue 23 | Box score |
| Oct 12, 1974 | Indiana 34, Minnesota 3 | Box score |
| Oct 12, 1974 | Iowa 35, Northwestern 10 | Box score |
| Oct 12, 1974 | 19Kansas 20, Kansas State 13 | Box score |
| Oct 12, 1974 | LSU 20, Tennessee 10 | Box score |
| Oct 12, 1974 | Louisiana Tech 35, Louisiana 20 | Box score |
| Oct 12, 1974 | Louisville 24, North Texas 10 | Box score |
| Oct 12, 1974 | Maryland 41, Clemson 0 | Box score |
| Oct 12, 1974 | Memphis 13, Cincinnati 7 | Box score |
| Oct 12, 1974 | 20Miami (OH) 31, Ohio 3 | Box score |
| Oct 12, 1974 | 4Michigan 21, Michigan State 7 | Box score |
| Oct 12, 1974 | Mississippi State 37, Lamar 21 | Box score |
| Oct 12, 1974 | Missouri 21, 5Nebraska 10upset | Box score |
| Oct 12, 1974 | New Mexico State 14, UTEP 13 | Box score |
| Oct 12, 1974 | 11NC State 22, Virginia 21 | Box score |
| Oct 12, 1974 | Northern Illinois 20, Marshall 17 | Box score |
| Oct 12, 1974 | 6Notre Dame 10, Rice 3 | Box score |
| Oct 12, 1974 | 1Ohio State 52, 13Wisconsin 7 | Box score |
| Oct 12, 1974 | 2Oklahoma 16, 17Texas 13 | Box score |
| Oct 12, 1974 | Oregon State 23, Washington 9 | Box score |
| Oct 12, 1974 | 15Penn State 55, Wake Forest 0 | Box score |
| Oct 12, 1974 | Cornell 28, Pennsylvania 28 | Box score |
| Oct 12, 1974 | Pittsburgh 31, West Virginia 14 | Box score |
| Oct 12, 1974 | Princeton 14, Dartmouth 7upset | Box score |
| Oct 12, 1974 | San Diego State 24, Fresno State 21 | Box score |
| Oct 12, 1974 | San José State 13, New Mexico 11 | Box score |
| Oct 12, 1974 | 7USC 54, Washington State 7 | Box score |
| Oct 12, 1974 | SMU 33, TCU 13 | Box score |
| Oct 12, 1974 | Southern Miss 39, Texas–Arlington 10 | Box score |
| Oct 12, 1974 | UCLA 13, Stanford 13 | Box score |
| Oct 12, 1974 | Syracuse 17, Navy 9 | Box score |
| Oct 12, 1974 | Tampa 47, Villanova 8 | Box score |
| Oct 12, 1974 | Temple 59, Southern Illinois 16 | Box score |
| Oct 12, 1974 | 16Texas A&M 28, 9Texas Tech 7upset | Box score |
| Oct 12, 1974 | Toledo 31, Western Michigan 24 | Box score |
| Oct 12, 1974 | Tulane 10, Air Force 3 | Box score |
| Oct 12, 1974 | Tulsa 35, Wichita State 13 | Box score |
| Oct 12, 1974 | Utah State 24, Colorado State 23 | Box score |
| Oct 12, 1974 | Vanderbilt 24, 8Florida 10upset | Box score |
| Oct 12, 1974 | VMI 20, The Citadel 9 | Box score |
| Oct 12, 1974 | Virginia Tech 31, South Carolina 17upset | Box score |
| Oct 12, 1974 | West Texas 21, Idaho 6 | Box score |
| Oct 12, 1974 | Yale 24, Brown 0 | Box score |