| Sep 28, 1974 | 4Alabama 23, Vanderbilt 10 | Box score |
| Sep 28, 1974 | 15Arizona 15, New Mexico 10 | Box score |
| Sep 28, 1974 | Arkansas 60, Tulsa 0 | Box score |
| Sep 28, 1974 | Auburn 21, 14Tennessee 0upset | Box score |
| Sep 28, 1974 | Baylor 31, 12Oklahoma State 14upset | Box score |
| Sep 28, 1974 | Bowling Green 21, Western Michigan 13 | Box score |
| Sep 28, 1974 | California 27, Army 14 | Box score |
| Sep 28, 1974 | Cincinnati 7, Louisville 6 | Box score |
| Sep 28, 1974 | Clemson 21, Georgia Tech 17 | Box score |
| Sep 28, 1974 | Colorado 24, 11Wisconsin 21upset | Box score |
| Sep 28, 1974 | Cornell 40, Colgate 21 | Box score |
| Sep 28, 1974 | Duke 27, Virginia 7 | Box score |
| Sep 28, 1974 | East Carolina 17, Southern Illinois 16 | Box score |
| Sep 28, 1974 | Florida 29, Mississippi State 13 | Box score |
| Sep 28, 1974 | Furman 10, William & Mary 0 | Box score |
| Sep 28, 1974 | Georgia 52, South Carolina 14 | Box score |
| Sep 28, 1974 | Harvard 24, Holy Cross 14 | Box score |
| Sep 28, 1974 | Houston 49, Virginia Tech 12 | Box score |
| Sep 28, 1974 | 16Illinois 21, Washington State 19 | Box score |
| Sep 28, 1974 | Iowa State 34, BYU 7 | Box score |
| Sep 28, 1974 | Kansas 40, Florida State 9 | Box score |
| Sep 28, 1974 | Kansas State 38, Pacific 7 | Box score |
| Sep 28, 1974 | Kentucky 28, Indiana 22 | Box score |
| Sep 28, 1974 | Lamar 27, North Texas 7 | Box score |
| Sep 28, 1974 | Long Beach State 20, Drake 13 | Box score |
| Sep 28, 1974 | Rice 10, 17LSU 10 | Box score |
| Sep 28, 1974 | Louisiana Tech 20, Arkansas State 7 | Box score |
| Sep 28, 1974 | Maryland 24, North Carolina 12 | Box score |
| Sep 28, 1974 | Memphis 20, Colorado State 18 | Box score |
| Sep 28, 1974 | 20Miami 28, Tampa 26 | Box score |
| Sep 28, 1974 | Miami (OH) 42, Marshall 0 | Box score |
| Sep 28, 1974 | 5Michigan 52, Navy 0 | Box score |
| Sep 28, 1974 | Minnesota 9, TCU 7 | Box score |
| Sep 28, 1974 | Ole Miss 20, Southern Miss 14 | Box score |
| Sep 28, 1974 | Missouri 9, 7Arizona State 0upset | Box score |
| Sep 28, 1974 | 10Nebraska 49, Northwestern 7 | Box score |
| Sep 28, 1974 | New Mexico State 42, Texas–Arlington 14 | Box score |
| Sep 28, 1974 | 13NC State 28, Syracuse 22 | Box score |
| Sep 28, 1974 | 1Ohio State 28, SMU 9 | Box score |
| Sep 28, 1974 | 3Oklahoma 72, Utah State 3 | Box score |
| Sep 28, 1974 | Oregon 23, Utah 16 | Box score |
| Sep 28, 1974 | 19Penn State 27, Iowa 0 | Box score |
| Sep 28, 1974 | Purdue 31, 2Notre Dame 20upset | Box score |
| Sep 28, 1974 | Richmond 27, The Citadel 24 | Box score |
| Sep 28, 1974 | Princeton 6, Rutgers 6 | Box score |
| Sep 28, 1974 | San Diego State 26, UTEP 12 | Box score |
| Sep 28, 1974 | Stanford 21, San José State 21 | Box score |
| Sep 28, 1974 | 18USC 16, 8Pittsburgh 7upset | Box score |
| Sep 28, 1974 | Temple 34, Boston College 7 | Box score |
| Sep 28, 1974 | 9Texas A&M 28, Washington 15 | Box score |
| Sep 28, 1974 | Texas Tech 26, 6Texas 3upset | Box score |
| Sep 28, 1974 | Toledo 19, Ohio 16upset | Box score |
| Sep 28, 1974 | Tulane 17, West Virginia 14 | Box score |
| Sep 28, 1974 | UCLA 56, Michigan State 14 | Box score |
| Sep 28, 1974 | Villanova 15, Idaho 7 | Box score |
| Sep 28, 1974 | VMI 43, Davidson 7 | Box score |
| Sep 28, 1974 | West Texas 41, Wichita State 7 | Box score |
| Sep 28, 1974 | Wyoming 20, Air Force 16 | Box score |