1974: Week 1
19 games. One ranked team lost. Two games matched two ranked teams. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Upsets
A ranked team beaten as the betting favorite, or, where no line is on file, by an unranked or lower-ranked team.
FBS vs. FBS
| Sep 7, 1974 | 15Arizona State 30, 11Houston 9upset | Box score |
| Sep 7, 1974 | Dayton 21, Drake 7 | Box score |
| Sep 7, 1974 | Memphis 16, Louisville 10 | Box score |
| Sep 7, 1974 | Mississippi State 49, William & Mary 7 | Box score |
| Sep 7, 1974 | New Mexico State 13, Wichita State 12 | Box score |
| Sep 7, 1974 | 18NC State 33, Wake Forest 15 | Box score |
| Sep 7, 1974 | Richmond 14, Villanova 13 | Box score |
| Sep 7, 1974 | Syracuse 23, Oregon State 15 | Box score |
| Sep 7, 1974 | 16Tennessee 17, 12UCLA 17 | Box score |
| Sep 7, 1974 | Western Michigan 33, Texas–Arlington 6 | Box score |
| Sep 9, 1974 | 3Notre Dame 31, Georgia Tech 7 | Box score |
Everyone else
| Sep 7, 1974 | App State 16, East Tennessee State 7 | Box score |
| Sep 7, 1974 | Cal Poly-Pomona 13, Fresno State 12upset | Box score |
| Sep 7, 1974 | Kent State 21, Central Michigan 14 | Box score |
| Sep 7, 1974 | McNeese 19, Northern Illinois 16upset | Box score |
| Sep 7, 1974 | Miami (OH) 39, Eastern Michigan 0 | Box score |
| Sep 7, 1974 | Pacific 21, Sacramento State 0 | Box score |
| Sep 7, 1974 | San José State 47, Santa Clara 10 | Box score |
| Sep 7, 1974 | Tampa 28, Chattanooga 0 | Box score |