| Sep 21, 1973 | 16Houston 27, South Carolina 19 | Box score |
| Sep 21, 1973 | Miami 20, 6Texas 15upset | Box score |
| Sep 22, 1973 | Air Force 24, Oregon 17 | Box score |
| Sep 22, 1973 | 4Alabama 28, Kentucky 14 | Box score |
| Sep 22, 1973 | Arizona 26, Indiana 10 | Box score |
| Sep 22, 1973 | 13Arizona State 20, Washington State 9 | Box score |
| Sep 22, 1973 | Baylor 20, Pittsburgh 14 | Box score |
| Sep 22, 1973 | 20Bowling Green 31, Dayton 16 | Box score |
| Sep 22, 1973 | 19Colorado 28, Wisconsin 25 | Box score |
| Sep 22, 1973 | Colorado State 31, New Mexico State 27 | Box score |
| Sep 22, 1973 | Duke 23, Washington 21 | Box score |
| Sep 22, 1973 | East Carolina 42, Southern Illinois 25 | Box score |
| Sep 22, 1973 | 15Florida 14, Southern Miss 13 | Box score |
| Sep 22, 1973 | Georgia 31, Clemson 14 | Box score |
| Sep 22, 1973 | Illinois 27, California 7 | Box score |
| Sep 22, 1973 | Iowa State 48, Idaho 0 | Box score |
| Sep 22, 1973 | Kansas 28, Florida State 0 | Box score |
| Sep 22, 1973 | Kansas State 21, Tulsa 0 | Box score |
| Sep 22, 1973 | Kent State 35, Ohio 7 | Box score |
| Sep 22, 1973 | 11LSU 28, Texas A&M 23 | Box score |
| Sep 22, 1973 | Louisiana Tech 23, Louisiana 0 | Box score |
| Sep 22, 1973 | Louisville 27, Drake 17 | Box score |
| Sep 22, 1973 | Maryland 23, North Carolina 3upset | Box score |
| Sep 22, 1973 | Memphis 17, Ole Miss 13 | Box score |
| Sep 22, 1973 | Miami (OH) 24, Purdue 19 | Box score |
| Sep 22, 1973 | 5Michigan 47, Stanford 10 | Box score |
| Sep 22, 1973 | Michigan State 14, Syracuse 8 | Box score |
| Sep 22, 1973 | Mississippi State 52, Vanderbilt 21 | Box score |
| Sep 22, 1973 | 20Missouri 31, Virginia 7 | Box score |
| Sep 22, 1973 | 2Nebraska 31, 14NC State 14 | Box score |
| Sep 22, 1973 | North Texas 32, West Texas 15 | Box score |
| Sep 22, 1973 | 8Notre Dame 44, Northwestern 0 | Box score |
| Sep 22, 1973 | 17Oklahoma State 38, Arkansas 6 | Box score |
| Sep 22, 1973 | 7Penn State 39, Navy 0 | Box score |
| Sep 22, 1973 | Richmond 35, VMI 0 | Box score |
| Sep 22, 1973 | San Diego State 35, Utah State 7 | Box score |
| Sep 22, 1973 | San José State 24, Long Beach State 6 | Box score |
| Sep 22, 1973 | 1USC 23, Georgia Tech 6 | Box score |
| Sep 22, 1973 | SMU 35, Oregon State 16 | Box score |
| Sep 22, 1973 | Tampa 34, Xavier 7 | Box score |
| Sep 22, 1973 | 10Tennessee 37, Army 18 | Box score |
| Sep 22, 1973 | TCU 49, Texas–Arlington 13 | Box score |
| Sep 22, 1973 | Texas Tech 41, New Mexico 7 | Box score |
| Sep 22, 1973 | Tulane 21, Boston College 16 | Box score |
| Sep 22, 1973 | 18UCLA 55, Iowa 18 | Box score |
| Sep 22, 1973 | Utah 82, UTEP 6 | Box score |
| Sep 22, 1973 | Villanova 14, Cincinnati 7 | Box score |
| Sep 22, 1973 | West Virginia 24, Virginia Tech 10 | Box score |
| Sep 22, 1973 | Western Michigan 28, Northern Illinois 14 | Box score |
| Sep 22, 1973 | Wichita State 14, Arkansas State 12 | Box score |
| Sep 22, 1973 | William & Mary 15, Wake Forest 14 | Box score |
| Sep 22, 1973 | Wyoming 49, Pacific 14 | Box score |