| Sep 15, 1973 | 6Alabama 66, California 0 | Box score |
| Sep 15, 1973 | Arizona 21, Wyoming 7 | Box score |
| Sep 15, 1973 | 13Arizona State 26, Oregon 20 | Box score |
| Sep 15, 1973 | Arkansas State 27, Louisiana 13 | Box score |
| Sep 15, 1973 | 12Auburn 18, Oregon State 9 | Box score |
| Sep 15, 1973 | Boston College 45, Temple 0 | Box score |
| Sep 15, 1973 | Bowling Green 41, Syracuse 14 | Box score |
| Sep 15, 1973 | Cincinnati 40, Xavier 7 | Box score |
| Sep 15, 1973 | Colorado State 21, BYU 13upset | Box score |
| Sep 15, 1973 | East Carolina 13, Southern Miss 0 | Box score |
| Sep 15, 1973 | 14Florida 21, Kansas State 10 | Box score |
| Sep 15, 1973 | Furman 17, App State 0 | Box score |
| Sep 15, 1973 | 18Houston 24, Rice 6 | Box score |
| Sep 15, 1973 | Illinois 28, Indiana 14 | Box score |
| Sep 15, 1973 | Kansas 29, Washington State 8 | Box score |
| Sep 15, 1973 | Kent State 10, Louisville 3 | Box score |
| Sep 15, 1973 | Kentucky 31, Virginia Tech 26 | Box score |
| Sep 15, 1973 | 15LSU 17, 10Colorado 6upset | Box score |
| Sep 15, 1973 | Mississippi State 21, UL Monroe 21 | Box score |
| Sep 15, 1973 | Memphis 24, North Texas 3 | Box score |
| Sep 15, 1973 | Miami (OH) 32, Dayton 0 | Box score |
| Sep 15, 1973 | 5Michigan 31, Iowa 7 | Box score |
| Sep 15, 1973 | Missouri 17, Ole Miss 0 | Box score |
| Sep 15, 1973 | Navy 37, VMI 6 | Box score |
| Sep 15, 1973 | New Mexico 48, New Mexico State 6 | Box score |
| Sep 15, 1973 | 19North Carolina 34, William & Mary 27 | Box score |
| Sep 15, 1973 | 17NC State 43, Virginia 23 | Box score |
| Sep 15, 1973 | Northern Illinois 34, Southern Illinois 28 | Box score |
| Sep 15, 1973 | Northwestern 14, Michigan State 10 | Box score |
| Sep 15, 1973 | 3Ohio State 56, Minnesota 7 | Box score |
| Sep 15, 1973 | 11Oklahoma 42, Baylor 14 | Box score |
| Sep 15, 1973 | Oklahoma State 56, Texas–Arlington 7 | Box score |
| Sep 15, 1973 | Pacific 34, UTEP 9 | Box score |
| Sep 15, 1973 | 7Penn State 20, Stanford 6 | Box score |
| Sep 15, 1973 | Georgia 7, Pittsburgh 7 | Box score |
| Sep 15, 1973 | Purdue 14, Wisconsin 13 | Box score |
| Sep 15, 1973 | Richmond 42, Davidson 0 | Box score |
| Sep 15, 1973 | San José State 24, Fresno State 6 | Box score |
| Sep 15, 1973 | South Carolina 41, Georgia Tech 28 | Box score |
| Sep 15, 1973 | 1USC 17, Arkansas 0 | Box score |
| Sep 15, 1973 | Tampa 35, Toledo 25 | Box score |
| Sep 15, 1973 | 9Tennessee 21, Duke 17 | Box score |
| Sep 15, 1973 | Texas A&M 48, Wichita State 0 | Box score |
| Sep 15, 1973 | 20Texas Tech 29, Utah 22 | Box score |
| Sep 15, 1973 | Tulsa 48, West Texas 3 | Box score |
| Sep 15, 1973 | Wake Forest 9, Florida State 7upset | Box score |
| Sep 15, 1973 | West Virginia 20, Maryland 13 | Box score |
| Sep 15, 1973 | Western Michigan 13, Long Beach State 8 | Box score |