| Oct 14, 1972 | 16Air Force 13, Boston College 9 | Box score |
| Oct 14, 1972 | 3Alabama 24, Florida 7 | Box score |
| Oct 14, 1972 | Arizona 27, New Mexico 15upset | Box score |
| Oct 14, 1972 | Arizona State 59, Utah 48 | Box score |
| Oct 14, 1972 | 20Arkansas 31, Baylor 20 | Box score |
| Oct 14, 1972 | BYU 21, UTEP 14 | Box score |
| Oct 14, 1972 | 13Colorado 34, 18Iowa State 22 | Box score |
| Oct 14, 1972 | Cornell 24, Pennsylvania 20 | Box score |
| Oct 14, 1972 | Dartmouth 35, Princeton 14 | Box score |
| Oct 14, 1972 | Duke 7, Clemson 0 | Box score |
| Oct 14, 1972 | East Carolina 27, The Citadel 21 | Box score |
| Oct 14, 1972 | Florida State 25, Mississippi State 21 | Box score |
| Oct 14, 1972 | Georgia 14, Ole Miss 13 | Box score |
| Oct 14, 1972 | Harvard 20, Columbia 18 | Box score |
| Oct 14, 1972 | Colgate 21, Holy Cross 21 | Box score |
| Oct 14, 1972 | Houston 49, San Diego State 14 | Box score |
| Oct 14, 1972 | Idaho 31, Northern Illinois 13 | Box score |
| Oct 14, 1972 | Indiana 33, Wisconsin 7 | Box score |
| Oct 14, 1972 | Iowa 23, Northwestern 12upset | Box score |
| Oct 14, 1972 | Kansas State 20, Kansas 19 | Box score |
| Oct 14, 1972 | Kent State 14, Bowling Green 10upset | Box score |
| Oct 14, 1972 | 8LSU 35, 9Auburn 7 | Box score |
| Oct 14, 1972 | Louisville 56, North Texas 6 | Box score |
| Oct 14, 1972 | Maryland 37, Villanova 7 | Box score |
| Oct 14, 1972 | Memphis 38, Utah State 29 | Box score |
| Oct 14, 1972 | Miami 24, Tulane 21 | Box score |
| Oct 14, 1972 | Miami (OH) 31, Ohio 7 | Box score |
| Oct 14, 1972 | 5Michigan 10, Michigan State 0 | Box score |
| Oct 14, 1972 | 6Nebraska 62, Missouri 0 | Box score |
| Oct 14, 1972 | North Carolina 31, Kentucky 20 | Box score |
| Oct 14, 1972 | NC State 42, Wake Forest 13 | Box score |
| Oct 14, 1972 | 7Notre Dame 42, Pittsburgh 16 | Box score |
| Oct 14, 1972 | 4Ohio State 26, Illinois 7 | Box score |
| Oct 14, 1972 | 2Oklahoma 27, 10Texas 0 | Box score |
| Oct 14, 1972 | Pacific 14, Long Beach State 10 | Box score |
| Oct 14, 1972 | 15Penn State 45, Army 0 | Box score |
| Oct 14, 1972 | Purdue 28, Minnesota 3 | Box score |
| Oct 14, 1972 | South Carolina 41, App State 7 | Box score |
| Oct 14, 1972 | 1USC 42, California 14 | Box score |
| Oct 14, 1972 | Southern Miss 34, Richmond 9 | Box score |
| Oct 14, 1972 | 17Stanford 24, 12Washington 0upset | Box score |
| Oct 14, 1972 | Syracuse 30, Navy 14 | Box score |
| Oct 14, 1972 | Temple 39, West Virginia 36upset | Box score |
| Oct 14, 1972 | TCU 35, Tulsa 9 | Box score |
| Oct 14, 1972 | Texas Tech 17, Texas A&M 14 | Box score |
| Oct 14, 1972 | Toledo 20, Western Michigan 13 | Box score |
| Oct 14, 1972 | 14UCLA 37, Oregon State 7 | Box score |
| Oct 14, 1972 | Vanderbilt 21, William & Mary 17 | Box score |
| Oct 14, 1972 | Virginia 45, VMI 14 | Box score |
| Oct 14, 1972 | Virginia Tech 34, 19Oklahoma State 32upset | Box score |
| Oct 14, 1972 | Washington State 31, Oregon 14 | Box score |
| Oct 14, 1972 | West Texas 63, New Mexico State 14 | Box score |
| Oct 14, 1972 | Wichita State 20, Cincinnati 17 | Box score |
| Oct 14, 1972 | Wyoming 28, Colorado State 9 | Box score |
| Oct 14, 1972 | Xavier 14, Marshall 0 | Box score |
| Oct 14, 1972 | Yale 53, Brown 19 | Box score |