| Oct 21, 1972 | 3Alabama 17, 10Tennessee 10 | Box score |
| Oct 21, 1972 | 19Arizona State 49, BYU 17 | Box score |
| Oct 21, 1972 | Army 35, Rutgers 28 | Box score |
| Oct 21, 1972 | 14Auburn 24, Georgia Tech 14 | Box score |
| Oct 21, 1972 | Clemson 37, Virginia 21 | Box score |
| Oct 21, 1972 | Colgate 35, Princeton 26upset | Box score |
| Oct 21, 1972 | 9Colorado 20, 2Oklahoma 14upset | Box score |
| Oct 21, 1972 | Dartmouth 49, Brown 20 | Box score |
| Oct 21, 1972 | Duke 20, Maryland 14 | Box score |
| Oct 21, 1972 | Florida 16, Ole Miss 0upset | Box score |
| Oct 21, 1972 | Florida State 37, Colorado State 0 | Box score |
| Oct 21, 1972 | Georgia 28, Vanderbilt 3 | Box score |
| Oct 21, 1972 | Harvard 33, Cornell 15 | Box score |
| Oct 21, 1972 | 20Iowa State 55, Kansas State 22 | Box score |
| Oct 21, 1972 | Kent State 26, Xavier 16 | Box score |
| Oct 21, 1972 | 7LSU 10, Kentucky 0 | Box score |
| Oct 21, 1972 | Louisville 46, Wichita State 3 | Box score |
| Oct 21, 1972 | Memphis 7, North Texas 6 | Box score |
| Oct 21, 1972 | Miami 33, Houston 13upset | Box score |
| Oct 21, 1972 | Miami (OH) 21, South Carolina 8 | Box score |
| Oct 21, 1972 | 6Michigan 31, Illinois 7 | Box score |
| Oct 21, 1972 | Michigan State 31, Wisconsin 0 | Box score |
| Oct 21, 1972 | Minnesota 43, Iowa 14 | Box score |
| Oct 21, 1972 | Mississippi State 26, Southern Miss 7 | Box score |
| Oct 21, 1972 | Missouri 30, 8Notre Dame 26upset | Box score |
| Oct 21, 1972 | Navy 21, 16Air Force 17upset | Box score |
| Oct 21, 1972 | 5Nebraska 56, Kansas 0 | Box score |
| Oct 21, 1972 | New Mexico 56, UTEP 7 | Box score |
| Oct 21, 1972 | New Mexico State 17, Texas–Arlington 12 | Box score |
| Oct 21, 1972 | North Carolina 21, Wake Forest 0 | Box score |
| Oct 21, 1972 | NC State 38, East Carolina 16 | Box score |
| Oct 21, 1972 | Northern Illinois 17, West Texas 8 | Box score |
| Oct 21, 1972 | 4Ohio State 44, Indiana 7 | Box score |
| Oct 21, 1972 | Oklahoma State 20, Baylor 7 | Box score |
| Oct 21, 1972 | Oregon 15, 13Stanford 13upset | Box score |
| Oct 21, 1972 | Pacific 38, San José State 28 | Box score |
| Oct 21, 1972 | 12Penn State 17, Syracuse 0 | Box score |
| Oct 21, 1972 | Pittsburgh 35, Boston College 20upset | Box score |
| Oct 21, 1972 | Purdue 37, Northwestern 0 | Box score |
| Oct 21, 1972 | San Diego State 35, Bowling Green 19 | Box score |
| Oct 21, 1972 | 1USC 34, 18Washington 7 | Box score |
| Oct 21, 1972 | SMU 29, Rice 14 | Box score |
| Oct 21, 1972 | Tampa 24, Drake 7 | Box score |
| Oct 21, 1972 | 14Texas 35, 17Arkansas 15 | Box score |
| Oct 21, 1972 | TCU 13, Texas A&M 10 | Box score |
| Oct 21, 1972 | Texas Tech 35, Arizona 10 | Box score |
| Oct 21, 1972 | Toledo 20, Dayton 17 | Box score |
| Oct 21, 1972 | 11UCLA 49, California 13 | Box score |
| Oct 21, 1972 | Utah 27, Wyoming 6 | Box score |
| Oct 21, 1972 | Virginia Tech 53, Ohio 21 | Box score |
| Oct 21, 1972 | Washington State 37, Oregon State 7 | Box score |
| Oct 21, 1972 | West Virginia 31, Tulane 19 | Box score |
| Oct 21, 1972 | Western Michigan 34, Marshall 0 | Box score |
| Oct 21, 1972 | William & Mary 31, VMI 3 | Box score |
| Oct 21, 1972 | Yale 28, Columbia 14 | Box score |