| Oct 7, 1972 | 19Air Force 52, Colorado State 13 | Box score |
| Oct 7, 1972 | 4Alabama 25, Georgia 7 | Box score |
| Oct 7, 1972 | Arizona State 38, Oregon State 7 | Box score |
| Oct 7, 1972 | Arkansas 27, TCU 13 | Box score |
| Oct 7, 1972 | 17Auburn 19, 18Ole Miss 13 | Box score |
| Oct 7, 1972 | Baylor 10, Miami 3 | Box score |
| Oct 7, 1972 | Boston College 21, Villanova 20 | Box score |
| Oct 7, 1972 | Bowling Green 19, Toledo 8upset | Box score |
| Oct 7, 1972 | BYU 38, Long Beach State 27upset | Box score |
| Oct 7, 1972 | Brown 28, Pennsylvania 20 | Box score |
| Oct 7, 1972 | The Citadel 42, VMI 3 | Box score |
| Oct 7, 1972 | 12Colorado 38, Kansas State 17 | Box score |
| Oct 7, 1972 | Princeton 0, Columbia 0 | Box score |
| Oct 7, 1972 | Cornell 36, Rutgers 22 | Box score |
| Oct 7, 1972 | Dartmouth 17, Holy Cross 7 | Box score |
| Oct 7, 1972 | Davidson 10, App State 10 | Box score |
| Oct 7, 1972 | East Carolina 21, Richmond 0 | Box score |
| Oct 7, 1972 | Florida 42, 13Florida State 13upset | Box score |
| Oct 7, 1972 | Georgia Tech 31, Clemson 9 | Box score |
| Oct 7, 1972 | Virginia Tech 27, Houston 27 | Box score |
| Oct 7, 1972 | Indiana 10, Syracuse 2 | Box score |
| Oct 7, 1972 | Kansas 34, Minnesota 28 | Box score |
| Oct 7, 1972 | Kentucky 17, Mississippi State 13 | Box score |
| Oct 7, 1972 | 8LSU 12, Rice 6 | Box score |
| Oct 7, 1972 | Louisiana Tech 35, Texas–Arlington 14 | Box score |
| Oct 7, 1972 | Louisville 17, Tampa 14 | Box score |
| Oct 7, 1972 | Maryland 23, Wake Forest 0 | Box score |
| Oct 7, 1972 | Miami (OH) 22, Marshall 7 | Box score |
| Oct 7, 1972 | 5Michigan 35, Navy 7 | Box score |
| Oct 7, 1972 | New Mexico 17, Wyoming 14 | Box score |
| Oct 7, 1972 | NC State 17, Duke 0 | Box score |
| Oct 7, 1972 | Northern Illinois 20, Xavier 7 | Box score |
| Oct 7, 1972 | 7Notre Dame 16, Michigan State 0 | Box score |
| Oct 7, 1972 | Ohio 28, Cincinnati 14 | Box score |
| Oct 7, 1972 | 3Ohio State 35, California 18 | Box score |
| Oct 7, 1972 | Oklahoma State 17, Missouri 16 | Box score |
| Oct 7, 1972 | Pacific 17, Fresno State 0upset | Box score |
| Oct 7, 1972 | 16Penn State 35, Illinois 17 | Box score |
| Oct 7, 1972 | Purdue 24, Iowa 0 | Box score |
| Oct 7, 1972 | San Diego State 23, San José State 12 | Box score |
| Oct 7, 1972 | 1USC 30, 15Stanford 21 | Box score |
| Oct 7, 1972 | SMU 55, New Mexico State 6 | Box score |
| Oct 7, 1972 | Southern Miss 14, West Texas 7 | Box score |
| Oct 7, 1972 | 10Tennessee 38, Memphis 7 | Box score |
| Oct 7, 1972 | 9Texas 27, Utah State 12 | Box score |
| Oct 7, 1972 | Texas Tech 35, Tulsa 18 | Box score |
| Oct 7, 1972 | Tulane 38, Pittsburgh 6 | Box score |
| Oct 7, 1972 | 14UCLA 42, Arizona 31 | Box score |
| Oct 7, 1972 | Utah 39, UTEP 20 | Box score |
| Oct 7, 1972 | Vanderbilt 10, Virginia 7 | Box score |
| Oct 7, 1972 | 11Washington 23, Oregon 17 | Box score |
| Oct 7, 1972 | Washington State 35, Idaho 14 | Box score |
| Oct 7, 1972 | West Virginia 49, William & Mary 34 | Box score |
| Oct 7, 1972 | Western Michigan 13, Kent State 12 | Box score |
| Oct 7, 1972 | Wichita State 23, North Texas 6 | Box score |
| Oct 7, 1972 | Wisconsin 21, Northwestern 14 | Box score |
| Oct 7, 1972 | Yale 27, Colgate 7 | Box score |