| Sep 23, 1972 | Air Force 41, Pittsburgh 13 | Box score |
| Sep 23, 1972 | 7Alabama 35, Kentucky 0 | Box score |
| Sep 23, 1972 | 10Arizona State 56, Kansas State 14 | Box score |
| Sep 23, 1972 | Arkansas 24, Oklahoma State 23 | Box score |
| Sep 23, 1972 | Baylor 27, Missouri 0upset | Box score |
| Sep 23, 1972 | Boston College 49, Temple 27 | Box score |
| Sep 23, 1972 | Bowling Green 16, Miami (OH) 7upset | Box score |
| Sep 23, 1972 | 3Colorado 38, Minnesota 6 | Box score |
| Sep 23, 1972 | Dayton 39, Marshall 0 | Box score |
| Sep 23, 1972 | Drake 23, Memphis 7 | Box score |
| Sep 23, 1972 | East Carolina 35, App State 7 | Box score |
| Sep 23, 1972 | 17Florida State 27, Virginia Tech 15 | Box score |
| Sep 23, 1972 | Fresno State 49, New Mexico State 17 | Box score |
| Sep 23, 1972 | Georgia Tech 21, 18Michigan State 16upset | Box score |
| Sep 23, 1972 | Holy Cross 30, Brown 24 | Box score |
| Sep 23, 1972 | Houston 21, Tulsa 0 | Box score |
| Sep 23, 1972 | Iowa 19, Oregon State 11 | Box score |
| Sep 23, 1972 | Iowa State 44, Utah 22 | Box score |
| Sep 23, 1972 | Kansas 52, Wyoming 14 | Box score |
| Sep 23, 1972 | Kent State 37, Ohio 14 | Box score |
| Sep 23, 1972 | 8LSU 42, Texas A&M 17 | Box score |
| Sep 23, 1972 | Maryland 28, VMI 16 | Box score |
| Sep 23, 1972 | 12Michigan 26, 6UCLA 9upset | Box score |
| Sep 23, 1972 | 20Ole Miss 21, South Carolina 0 | Box score |
| Sep 23, 1972 | Mississippi State 10, Vanderbilt 6 | Box score |
| Sep 23, 1972 | 9Nebraska 77, Army 7 | Box score |
| Sep 23, 1972 | North Carolina 34, NC State 33 | Box score |
| Sep 23, 1972 | 13Notre Dame 37, Northwestern 0 | Box score |
| Sep 23, 1972 | 2Oklahoma 68, Oregon 3 | Box score |
| Sep 23, 1972 | Pacific 19, UTEP 14 | Box score |
| Sep 23, 1972 | 11Penn State 21, Navy 10 | Box score |
| Sep 23, 1972 | Rice 29, Clemson 10 | Box score |
| Sep 23, 1972 | Richmond 17, UL Monroe 0 | Box score |
| Sep 23, 1972 | San Diego State 25, North Texas 0 | Box score |
| Sep 23, 1972 | San José State 17, California 10upset | Box score |
| Sep 23, 1972 | 1USC 55, Illinois 20 | Box score |
| Sep 23, 1972 | SMU 21, Florida 14 | Box score |
| Sep 23, 1972 | 19Stanford 10, Duke 6 | Box score |
| Sep 23, 1972 | 5Tennessee 45, Wake Forest 6 | Box score |
| Sep 23, 1972 | 14Texas 23, Miami 10 | Box score |
| Sep 23, 1972 | TCU 31, Indiana 28 | Box score |
| Sep 23, 1972 | Texas Tech 41, New Mexico 16 | Box score |
| Sep 23, 1972 | Toledo 38, Texas–Arlington 24 | Box score |
| Sep 23, 1972 | Tulane 24, 16Georgia 13upset | Box score |
| Sep 23, 1972 | Utah State 42, BYU 19 | Box score |
| Sep 23, 1972 | Villanova 20, William & Mary 17 | Box score |
| Sep 23, 1972 | 15Washington 22, Purdue 21 | Box score |
| Sep 23, 1972 | Washington State 28, Arizona 6 | Box score |
| Sep 23, 1972 | West Texas 41, Colorado State 14 | Box score |
| Sep 23, 1972 | West Virginia 48, Virginia 10 | Box score |
| Sep 23, 1972 | Western Michigan 14, Northern Illinois 10 | Box score |
| Sep 23, 1972 | Wichita State 6, Arkansas State 0upset | Box score |
| Sep 23, 1972 | Wisconsin 31, Syracuse 7 | Box score |
| Sep 23, 1972 | Xavier 19, Cincinnati 7upset | Box score |