| Sep 16, 1972 | Air Force 45, Wyoming 14 | Box score |
| Sep 16, 1972 | 13Arizona State 33, Houston 28 | Box score |
| Sep 16, 1972 | Bowling Green 17, 18Purdue 14upset | Box score |
| Sep 16, 1972 | BYU 32, Kansas State 9 | Box score |
| Sep 16, 1972 | California 37, Washington State 23 | Box score |
| Sep 16, 1972 | The Citadel 28, App State 21 | Box score |
| Sep 16, 1972 | 2Colorado 56, Cincinnati 14 | Box score |
| Sep 16, 1972 | Davidson 18, VMI 14 | Box score |
| Sep 16, 1972 | Drake 40, West Texas 12 | Box score |
| Sep 16, 1972 | 20Florida State 37, Miami 14 | Box score |
| Sep 16, 1972 | Fresno State 41, Western Michigan 14 | Box score |
| Sep 16, 1972 | 16Georgia 24, Baylor 14 | Box score |
| Sep 16, 1972 | Georgia Tech 34, South Carolina 6 | Box score |
| Sep 16, 1972 | Holy Cross 24, Rutgers 14 | Box score |
| Sep 16, 1972 | Idaho 17, Ohio 14 | Box score |
| Sep 16, 1972 | Indiana 27, Minnesota 23 | Box score |
| Sep 16, 1972 | Iowa State 41, Colorado State 0 | Box score |
| Sep 16, 1972 | Kentucky 25, Villanova 7 | Box score |
| Sep 16, 1972 | Long Beach State 24, North Texas 21 | Box score |
| Sep 16, 1972 | 9LSU 31, Pacific 13 | Box score |
| Sep 16, 1972 | Louisiana Tech 33, Southern Miss 14upset | Box score |
| Sep 16, 1972 | Louisville 34, Kent State 0 | Box score |
| Sep 16, 1972 | Miami (OH) 34, Dayton 7 | Box score |
| Sep 16, 1972 | 11Michigan 7, Northwestern 0 | Box score |
| Sep 16, 1972 | Michigan State 24, Illinois 0 | Box score |
| Sep 16, 1972 | 19Ole Miss 34, Memphis 29 | Box score |
| Sep 16, 1972 | Mississippi State 42, UL Monroe 7 | Box score |
| Sep 16, 1972 | Navy 13, William & Mary 9 | Box score |
| Sep 16, 1972 | 10Nebraska 37, Texas A&M 7 | Box score |
| Sep 16, 1972 | New Mexico 55, New Mexico State 20 | Box score |
| Sep 16, 1972 | North Carolina 31, Maryland 26 | Box score |
| Sep 16, 1972 | NC State 43, Syracuse 20 | Box score |
| Sep 16, 1972 | 3Ohio State 21, Iowa 0 | Box score |
| Sep 16, 1972 | 4Oklahoma 49, Utah State 0 | Box score |
| Sep 16, 1972 | Oklahoma State 21, Texas–Arlington 3 | Box score |
| Sep 16, 1972 | Oregon 34, Arizona 7 | Box score |
| Sep 16, 1972 | 1USC 51, Oregon State 6 | Box score |
| Sep 16, 1972 | SMU 56, Wake Forest 10 | Box score |
| Sep 16, 1972 | Stanford 44, San José State 0 | Box score |
| Sep 16, 1972 | Temple 16, Xavier 12 | Box score |
| Sep 16, 1972 | 7Tennessee 28, 6Penn State 21upset | Box score |
| Sep 16, 1972 | Texas Tech 45, Utah 2 | Box score |
| Sep 16, 1972 | Tulane 10, Boston College 0upset | Box score |
| Sep 16, 1972 | Tulsa 10, Wichita State 9 | Box score |
| Sep 16, 1972 | 8UCLA 38, Pittsburgh 28 | Box score |
| Sep 16, 1972 | Virginia 24, Virginia Tech 20 | Box score |
| Sep 16, 1972 | 12Washington 14, Duke 6 | Box score |
| Sep 16, 1972 | West Virginia 28, Richmond 7 | Box score |
| Sep 16, 1972 | Wisconsin 31, Northern Illinois 7 | Box score |