| Sep 18, 1971 | Air Force 7, Missouri 6 | Box score |
| Sep 18, 1971 | 9Alabama 42, Southern Miss 6 | Box score |
| Sep 18, 1971 | Arizona 39, Washington State 28 | Box score |
| Sep 18, 1971 | 16Arizona State 18, 20Houston 17 | Box score |
| Sep 18, 1971 | 6Arkansas 31, Oklahoma State 10 | Box score |
| Sep 18, 1971 | Arkansas State 16, Wichita State 14 | Box score |
| Sep 18, 1971 | Boston College 17, Temple 3 | Box score |
| Sep 18, 1971 | Bowling Green 20, Ohio 19upset | Box score |
| Sep 18, 1971 | BYU 54, Colorado State 14 | Box score |
| Sep 18, 1971 | California 20, West Virginia 10 | Box score |
| Sep 18, 1971 | Cincinnati 42, Kent State 20 | Box score |
| Sep 18, 1971 | 12Colorado 56, Wyoming 13 | Box score |
| Sep 18, 1971 | Duke 28, 19South Carolina 12upset | Box score |
| Sep 18, 1971 | Florida State 20, Miami 17 | Box score |
| Sep 18, 1971 | Fresno State 14, San José State 7 | Box score |
| Sep 18, 1971 | 11Georgia 17, Tulane 7 | Box score |
| Sep 18, 1971 | Georgia Tech 10, 18Michigan State 0upset | Box score |
| Sep 18, 1971 | Indiana 26, Kentucky 8 | Box score |
| Sep 18, 1971 | Iowa State 24, Idaho 7 | Box score |
| Sep 18, 1971 | Kansas 22, Baylor 0 | Box score |
| Sep 18, 1971 | Kansas State 19, Tulsa 10 | Box score |
| Sep 18, 1971 | LSU 37, Texas A&M 0 | Box score |
| Sep 18, 1971 | Vanderbilt 0, Louisville 0 | Box score |
| Sep 18, 1971 | Maryland 35, NC State 7 | Box score |
| Sep 18, 1971 | Miami (OH) 17, Xavier 7 | Box score |
| Sep 18, 1971 | 4Michigan 56, Virginia 0 | Box score |
| Sep 18, 1971 | Ole Miss 49, Memphis 21 | Box score |
| Sep 18, 1971 | Mississippi State 13, Florida 10 | Box score |
| Sep 18, 1971 | 1Nebraska 35, Minnesota 7 | Box score |
| Sep 18, 1971 | New Mexico 13, Texas Tech 10 | Box score |
| Sep 18, 1971 | North Carolina 27, Illinois 0 | Box score |
| Sep 18, 1971 | Northern Illinois 48, Long Beach State 38 | Box score |
| Sep 18, 1971 | 2Notre Dame 50, Northwestern 7 | Box score |
| Sep 18, 1971 | 10Oklahoma 30, SMU 0 | Box score |
| Sep 18, 1971 | Oregon 36, Utah 29 | Box score |
| Sep 18, 1971 | Oregon State 33, Iowa 19 | Box score |
| Sep 18, 1971 | 14Penn State 56, Navy 3 | Box score |
| Sep 18, 1971 | 17USC 24, Rice 0 | Box score |
| Sep 18, 1971 | 13Stanford 38, Army 3 | Box score |
| Sep 18, 1971 | 8Tennessee 48, California–Santa Barbara 6 | Box score |
| Sep 18, 1971 | 3Texas 28, UCLA 10 | Box score |
| Sep 18, 1971 | TCU 42, Texas–Arlington 0 | Box score |
| Sep 18, 1971 | UTEP 21, Pacific 3 | Box score |
| Sep 18, 1971 | Toledo 10, Villanova 7 | Box score |
| Sep 18, 1971 | Utah State 34, New Mexico State 0 | Box score |
| Sep 18, 1971 | VMI 27, Davidson 3 | Box score |
| Sep 18, 1971 | Wake Forest 20, Virginia Tech 9 | Box score |
| Sep 18, 1971 | Washington 38, Purdue 35 | Box score |
| Sep 18, 1971 | William & Mary 28, East Carolina 10 | Box score |
| Sep 18, 1971 | 15Syracuse 20, Wisconsin 20 | Box score |