| Sep 10, 1971 | 16Alabama 17, 5USC 10upset | Box score |
| Sep 10, 1971 | BYU 41, North Texas 13 | Box score |
| Sep 11, 1971 | 7Arkansas 51, California 20 | Box score |
| Sep 11, 1971 | Colorado 31, 9LSU 21upset | Box score |
| Sep 11, 1971 | Dayton 16, Cincinnati 3 | Box score |
| Sep 11, 1971 | Duke 12, Florida 6upset | Box score |
| Sep 11, 1971 | Florida State 24, Southern Miss 9 | Box score |
| Sep 11, 1971 | 18Georgia 56, Oregon State 25 | Box score |
| Sep 11, 1971 | Houston 23, Rice 21 | Box score |
| Sep 11, 1971 | Kansas 34, Washington State 0 | Box score |
| Sep 11, 1971 | Kent State 23, NC State 21 | Box score |
| Sep 11, 1971 | Kentucky 13, Clemson 10 | Box score |
| Sep 11, 1971 | Louisiana Tech 28, Tampa 20 | Box score |
| Sep 11, 1971 | Memphis 30, West Texas 0 | Box score |
| Sep 11, 1971 | Miami (OH) 17, Pacific 10 | Box score |
| Sep 11, 1971 | 4Michigan 21, 20Northwestern 6 | Box score |
| Sep 11, 1971 | Michigan State 10, Illinois 0 | Box score |
| Sep 11, 1971 | Minnesota 28, Indiana 0 | Box score |
| Sep 11, 1971 | Ole Miss 29, Long Beach State 13 | Box score |
| Sep 11, 1971 | Navy 10, Virginia 6 | Box score |
| Sep 11, 1971 | 2Nebraska 34, Oregon 7 | Box score |
| Sep 11, 1971 | New Mexico State 7, Drake 3 | Box score |
| Sep 11, 1971 | North Carolina 28, Richmond 0 | Box score |
| Sep 11, 1971 | 11Ohio State 52, Iowa 21 | Box score |
| Sep 11, 1971 | Oklahoma State 26, Mississippi State 7 | Box score |
| Sep 11, 1971 | Pittsburgh 29, 15UCLA 25upset | Box score |
| Sep 11, 1971 | South Carolina 24, 17Georgia Tech 7upset | Box score |
| Sep 11, 1971 | 19Stanford 19, Missouri 0 | Box score |
| Sep 11, 1971 | Texas A&M 41, Wichita State 7 | Box score |
| Sep 11, 1971 | UTEP 38, Texas–Arlington 9 | Box score |
| Sep 11, 1971 | Toledo 45, East Carolina 0 | Box score |
| Sep 11, 1971 | Tulane 15, Texas Tech 9 | Box score |
| Sep 11, 1971 | Utah State 10, Kansas State 7upset | Box score |
| Sep 11, 1971 | Villanova 28, Maryland 13 | Box score |
| Sep 11, 1971 | Wake Forest 27, Davidson 7 | Box score |
| Sep 11, 1971 | Washington 65, California–Santa Barbara 7 | Box score |
| Sep 11, 1971 | West Virginia 45, Boston College 14 | Box score |
| Sep 11, 1971 | William & Mary 35, The Citadel 28 | Box score |
| Sep 11, 1971 | Wisconsin 31, Northern Illinois 0 | Box score |