| Oct 18, 1969 | Air Force 60, Oregon 13 | Box score |
| Oct 18, 1969 | Arizona 26, UTEP 10 | Box score |
| Oct 18, 1969 | Arizona State 45, San José State 11 | Box score |
| Oct 18, 1969 | 4Arkansas 21, Baylor 7 | Box score |
| Oct 18, 1969 | 15Auburn 17, Georgia Tech 14 | Box score |
| Oct 18, 1969 | Bowling Green 7, Kent State 0 | Box score |
| Oct 18, 1969 | Cincinnati 21, Wichita State 14 | Box score |
| Oct 18, 1969 | The Citadel 28, VMI 2 | Box score |
| Oct 18, 1969 | Clemson 28, Wake Forest 14 | Box score |
| Oct 18, 1969 | Colgate 35, Princeton 28upset | Box score |
| Oct 18, 1969 | Colorado State 27, West Texas 7 | Box score |
| Oct 18, 1969 | Cornell 41, Harvard 24upset | Box score |
| Oct 18, 1969 | Dartmouth 38, Brown 13 | Box score |
| Oct 18, 1969 | Davidson 17, William & Mary 15 | Box score |
| Oct 18, 1969 | Dayton 56, Northern Illinois 24 | Box score |
| Oct 18, 1969 | 10Florida 52, North Carolina 2 | Box score |
| Oct 18, 1969 | Florida State 38, Tulsa 20 | Box score |
| Oct 18, 1969 | 14Georgia 40, Vanderbilt 8 | Box score |
| Oct 18, 1969 | Indiana 41, Illinois 20 | Box score |
| Oct 18, 1969 | Kansas State 34, Iowa State 7 | Box score |
| Oct 18, 1969 | 9LSU 37, Kentucky 10 | Box score |
| Oct 18, 1969 | Louisville 34, Marshall 17 | Box score |
| Oct 18, 1969 | Maryland 20, Duke 7 | Box score |
| Oct 18, 1969 | Memphis 26, Miami 13 | Box score |
| Oct 18, 1969 | Miami (OH) 24, Ohio 21 | Box score |
| Oct 18, 1969 | Michigan State 23, 13Michigan 12upset | Box score |
| Oct 18, 1969 | 19Ole Miss 69, Southern Miss 7 | Box score |
| Oct 18, 1969 | Mississippi State 30, Texas Tech 26upset | Box score |
| Oct 18, 1969 | 6Missouri 31, Oklahoma State 21 | Box score |
| Oct 18, 1969 | Nebraska 21, Kansas 17 | Box score |
| Oct 18, 1969 | NC State 31, Virginia 0 | Box score |
| Oct 18, 1969 | North Texas 30, New Mexico State 12 | Box score |
| Oct 18, 1969 | Northwestern 27, Wisconsin 7 | Box score |
| Oct 18, 1969 | 1Ohio State 34, Minnesota 7 | Box score |
| Oct 18, 1969 | 12Oklahoma 42, Colorado 30 | Box score |
| Oct 18, 1969 | Oregon State 10, Washington 6 | Box score |
| Oct 18, 1969 | Pacific 28, Idaho 0 | Box score |
| Oct 18, 1969 | 5Penn State 15, Syracuse 14 | Box score |
| Oct 18, 1969 | 17Purdue 35, Iowa 31 | Box score |
| Oct 18, 1969 | Richmond 24, East Carolina 7 | Box score |
| Oct 18, 1969 | Rutgers 20, Navy 6 | Box score |
| Oct 18, 1969 | South Carolina 17, Virginia Tech 16 | Box score |
| Oct 18, 1969 | 11Notre Dame 14, 3USC 14 | Box score |
| Oct 18, 1969 | SMU 34, Rice 14 | Box score |
| Oct 18, 1969 | 18Stanford 49, Washington State 0 | Box score |
| Oct 18, 1969 | 7Tennessee 41, 20Alabama 14 | Box score |
| Oct 18, 1969 | TCU 16, Texas A&M 6 | Box score |
| Oct 18, 1969 | Toledo 38, Western Michigan 13 | Box score |
| Oct 18, 1969 | Tulane 26, Pittsburgh 22 | Box score |
| Oct 18, 1969 | 8UCLA 32, California 0 | Box score |
| Oct 18, 1969 | Utah 24, New Mexico 0 | Box score |
| Oct 18, 1969 | Utah State 23, Army 7upset | Box score |
| Oct 18, 1969 | Villanova 24, Boston College 6 | Box score |
| Oct 18, 1969 | 16Wyoming 40, BYU 7 | Box score |
| Oct 18, 1969 | Yale 41, Columbia 6 | Box score |