| Oct 10, 1969 | 14LSU 20, Miami 0 | Box score |
| Oct 10, 1969 | SMU 19, TCU 17 | Box score |
| Oct 11, 1969 | Air Force 20, North Carolina 10 | Box score |
| Oct 11, 1969 | 20Auburn 51, Clemson 0 | Box score |
| Oct 11, 1969 | BYU 41, New Mexico 15 | Box score |
| Oct 11, 1969 | Buffalo 27, Dayton 0 | Box score |
| Oct 11, 1969 | California 44, Washington 13 | Box score |
| Oct 11, 1969 | Colorado 14, Iowa State 0 | Box score |
| Oct 11, 1969 | Colorado State 37, Utah State 33upset | Box score |
| Oct 11, 1969 | Dartmouth 41, Pennsylvania 0 | Box score |
| Oct 11, 1969 | Davidson 37, Richmond 7 | Box score |
| Oct 11, 1969 | Duke 27, Wake Forest 20 | Box score |
| Oct 11, 1969 | 12Florida 18, Tulane 17 | Box score |
| Oct 11, 1969 | Harvard 51, Columbia 0 | Box score |
| Oct 11, 1969 | Houston 34, Arizona 17 | Box score |
| Oct 11, 1969 | Indiana 17, Minnesota 7 | Box score |
| Oct 11, 1969 | Kansas State 26, Kansas 22 | Box score |
| Oct 11, 1969 | Kentucky 7, Virginia Tech 6upset | Box score |
| Oct 11, 1969 | Memphis 52, Cincinnati 6 | Box score |
| Oct 11, 1969 | Miami (OH) 35, Marshall 7 | Box score |
| Oct 11, 1969 | Michigan 31, 9Purdue 20upset | Box score |
| Oct 11, 1969 | Ole Miss 25, 6Georgia 17upset | Box score |
| Oct 11, 1969 | Mississippi State 34, Southern Miss 20 | Box score |
| Oct 11, 1969 | 7Missouri 17, 20Nebraska 7 | Box score |
| Oct 11, 1969 | New Mexico State 23, Wichita State 6 | Box score |
| Oct 11, 1969 | Northwestern 10, Illinois 6 | Box score |
| Oct 11, 1969 | 15Notre Dame 45, Army 0 | Box score |
| Oct 11, 1969 | Ohio 31, Xavier 6 | Box score |
| Oct 11, 1969 | 1Ohio State 54, 19Michigan State 21 | Box score |
| Oct 11, 1969 | Pacific 38, California–Santa Barbara 0 | Box score |
| Oct 11, 1969 | 5Penn State 20, 17West Virginia 0 | Box score |
| Oct 11, 1969 | Pittsburgh 46, Navy 19 | Box score |
| Oct 11, 1969 | Princeton 24, Cornell 17 | Box score |
| Oct 11, 1969 | San Diego State 24, West Texas 14upset | Box score |
| Oct 11, 1969 | San José State 36, Oregon 34upset | Box score |
| Oct 11, 1969 | South Carolina 21, NC State 16 | Box score |
| Oct 11, 1969 | 4USC 26, 16Stanford 24 | Box score |
| Oct 11, 1969 | Syracuse 20, Maryland 9 | Box score |
| Oct 11, 1969 | 10Tennessee 26, Georgia Tech 8 | Box score |
| Oct 11, 1969 | 2Texas 27, 8Oklahoma 17 | Box score |
| Oct 11, 1969 | Texas Tech 13, Texas A&M 9 | Box score |
| Oct 11, 1969 | Toledo 27, Bowling Green 26 | Box score |
| Oct 11, 1969 | 11UCLA 46, Washington State 14 | Box score |
| Oct 11, 1969 | Utah 24, Arizona State 23 | Box score |
| Oct 11, 1969 | Vanderbilt 14, 13Alabama 10upset | Box score |
| Oct 11, 1969 | Virginia 28, VMI 10 | Box score |
| Oct 11, 1969 | Western Michigan 33, Kent State 13 | Box score |
| Oct 11, 1969 | William & Mary 21, The Citadel 14 | Box score |
| Oct 11, 1969 | Wisconsin 23, Iowa 17upset | Box score |
| Oct 11, 1969 | 18Wyoming 37, UTEP 9 | Box score |
| Oct 11, 1969 | Yale 27, Brown 13 | Box score |