| Oct 3, 1969 | Idaho 31, Southern Miss 21upset | Box score |
| Oct 3, 1969 | Miami 23, NC State 13 | Box score |
| Oct 4, 1969 | 15Alabama 33, 20Ole Miss 32 | Box score |
| Oct 4, 1969 | Arizona State 23, BYU 7 | Box score |
| Oct 4, 1969 | 3Arkansas 24, TCU 6 | Box score |
| Oct 4, 1969 | Auburn 44, Kentucky 3 | Box score |
| Oct 4, 1969 | Boston College 28, Tulane 24 | Box score |
| Oct 4, 1969 | Bowling Green 21, Western Michigan 10 | Box score |
| Oct 4, 1969 | California 31, Rice 21 | Box score |
| Oct 4, 1969 | Cincinnati 17, Xavier 14 | Box score |
| Oct 4, 1969 | The Citadel 31, East Carolina 13 | Box score |
| Oct 4, 1969 | Clemson 21, Georgia Tech 10 | Box score |
| Oct 4, 1969 | Colorado 30, Indiana 7 | Box score |
| Oct 4, 1969 | Dartmouth 38, Holy Cross 6 | Box score |
| Oct 4, 1969 | Drake 27, North Texas 23 | Box score |
| Oct 4, 1969 | 12Florida 21, Florida State 6 | Box score |
| Oct 4, 1969 | 7Georgia 41, South Carolina 16 | Box score |
| Oct 4, 1969 | Houston 74, Mississippi State 0 | Box score |
| Oct 4, 1969 | Iowa 31, Arizona 19 | Box score |
| Oct 4, 1969 | Iowa State 48, Illinois 20 | Box score |
| Oct 4, 1969 | Kent State 17, Buffalo 8 | Box score |
| Oct 4, 1969 | 16LSU 63, Baylor 8 | Box score |
| Oct 4, 1969 | Louisville 24, Dayton 17 | Box score |
| Oct 4, 1969 | Maryland 19, Wake Forest 14upset | Box score |
| Oct 4, 1969 | 9Missouri 40, 13Michigan 17 | Box score |
| Oct 4, 1969 | Nebraska 42, Minnesota 14 | Box score |
| Oct 4, 1969 | New Mexico 16, Kansas 7upset | Box score |
| Oct 4, 1969 | North Carolina 38, Vanderbilt 22 | Box score |
| Oct 4, 1969 | Northern Illinois 18, Marshall 17upset | Box score |
| Oct 4, 1969 | Notre Dame 42, 14Michigan State 28upset | Box score |
| Oct 4, 1969 | 1Ohio State 41, Washington 14 | Box score |
| Oct 4, 1969 | Oklahoma State 17, Texas Tech 10 | Box score |
| Oct 4, 1969 | Oregon 25, Washington State 24 | Box score |
| Oct 4, 1969 | Pacific 40, Fresno State 21 | Box score |
| Oct 4, 1969 | 2Penn State 17, Kansas State 14 | Box score |
| Oct 4, 1969 | Pennsylvania 23, Brown 2 | Box score |
| Oct 4, 1969 | Pittsburgh 14, Duke 12upset | Box score |
| Oct 4, 1969 | Princeton 21, Columbia 7 | Box score |
| Oct 4, 1969 | 8Purdue 36, 17Stanford 35 | Box score |
| Oct 4, 1969 | Richmond 17, Virginia Tech 10 | Box score |
| Oct 4, 1969 | Rutgers 21, Cornell 7 | Box score |
| Oct 4, 1969 | San Diego State 55, San José State 21 | Box score |
| Oct 4, 1969 | 5USC 31, Oregon State 7 | Box score |
| Oct 4, 1969 | Syracuse 43, Wisconsin 7 | Box score |
| Oct 4, 1969 | 10Tennessee 55, Memphis 16 | Box score |
| Oct 4, 1969 | 4Texas 56, Navy 17 | Box score |
| Oct 4, 1969 | Texas A&M 20, Army 13upset | Box score |
| Oct 4, 1969 | Toledo 34, Ohio 9 | Box score |
| Oct 4, 1969 | 11UCLA 36, Northwestern 0 | Box score |
| Oct 4, 1969 | Utah 24, UTEP 6upset | Box score |
| Oct 4, 1969 | Virginia 28, William & Mary 15 | Box score |
| Oct 4, 1969 | West Texas 24, Wichita State 14 | Box score |
| Oct 4, 1969 | 18West Virginia 32, VMI 0 | Box score |
| Oct 4, 1969 | 19Wyoming 39, Colorado State 3 | Box score |
| Oct 4, 1969 | Yale 40, Colgate 21 | Box score |