| Sep 26, 1969 | Florida State 16, Miami 14 | Box score |
| Sep 27, 1969 | 15Alabama 63, Southern Miss 14 | Box score |
| Sep 27, 1969 | 3Arkansas 55, Tulsa 0 | Box score |
| Sep 27, 1969 | Army 16, Vanderbilt 6 | Box score |
| Sep 27, 1969 | Boston College 21, Navy 14 | Box score |
| Sep 27, 1969 | Bowling Green 27, Dayton 7 | Box score |
| Sep 27, 1969 | California 17, 10Indiana 14upset | Box score |
| Sep 27, 1969 | The Citadel 14, Arkansas State 10 | Box score |
| Sep 27, 1969 | Colgate 28, Cornell 24upset | Box score |
| Sep 27, 1969 | Colorado State 50, Wichita State 21 | Box score |
| Sep 27, 1969 | 12Florida 47, Mississippi State 35 | Box score |
| Sep 27, 1969 | 7Georgia 30, Clemson 0 | Box score |
| Sep 27, 1969 | Georgia Tech 17, Baylor 10 | Box score |
| Sep 27, 1969 | Harvard 13, Holy Cross 0 | Box score |
| Sep 27, 1969 | Iowa 61, Washington State 35 | Box score |
| Sep 27, 1969 | Iowa State 10, BYU 0 | Box score |
| Sep 27, 1969 | Kansas 13, Syracuse 0 | Box score |
| Sep 27, 1969 | Kansas State 42, Arizona 27 | Box score |
| Sep 27, 1969 | Kent State 23, Xavier 7 | Box score |
| Sep 27, 1969 | Kentucky 10, 8Ole Miss 9upset | Box score |
| Sep 27, 1969 | LSU 42, Rice 0 | Box score |
| Sep 27, 1969 | Memphis 15, North Texas 13 | Box score |
| Sep 27, 1969 | Miami (OH) 24, Western Michigan 20 | Box score |
| Sep 27, 1969 | 20Michigan 45, Washington 7 | Box score |
| Sep 27, 1969 | 13Michigan State 23, SMU 15 | Box score |
| Sep 27, 1969 | 11Missouri 37, Illinois 6 | Box score |
| Sep 27, 1969 | Nebraska 14, Texas A&M 0 | Box score |
| Sep 27, 1969 | NC State 24, Maryland 7 | Box score |
| Sep 27, 1969 | Minnesota 35, Ohio 35 | Box score |
| Sep 27, 1969 | 1Ohio State 62, TCU 0 | Box score |
| Sep 27, 1969 | 6Oklahoma 37, Pittsburgh 8 | Box score |
| Sep 27, 1969 | Oklahoma State 24, Houston 18 | Box score |
| Sep 27, 1969 | Oregon State 30, 18Arizona State 7upset | Box score |
| Sep 27, 1969 | Pacific 36, Utah State 3upset | Box score |
| Sep 27, 1969 | 2Penn State 27, Colorado 3 | Box score |
| Sep 27, 1969 | 16Purdue 28, 9Notre Dame 14upset | Box score |
| Sep 27, 1969 | Richmond 20, VMI 0 | Box score |
| Sep 27, 1969 | Rutgers 29, Princeton 0 | Box score |
| Sep 27, 1969 | San Diego State 49, Cal State Los Angeles 0 | Box score |
| Sep 27, 1969 | South Carolina 14, North Carolina 6 | Box score |
| Sep 27, 1969 | 5USC 48, Northwestern 6 | Box score |
| Sep 27, 1969 | Stanford 28, Oregon 0 | Box score |
| Sep 27, 1969 | 19Tennessee 45, 17Auburn 19upset | Box score |
| Sep 27, 1969 | 4Texas 49, Texas Tech 7 | Box score |
| Sep 27, 1969 | UTEP 21, New Mexico 6 | Box score |
| Sep 27, 1969 | Toledo 38, Marshall 13 | Box score |
| Sep 27, 1969 | 14UCLA 34, Wisconsin 23 | Box score |
| Sep 27, 1969 | Utah 42, San José State 7 | Box score |
| Sep 27, 1969 | Virginia 10, Duke 0 | Box score |
| Sep 27, 1969 | Wake Forest 16, Virginia Tech 10 | Box score |
| Sep 27, 1969 | West Texas 22, Northern Illinois 7 | Box score |
| Sep 27, 1969 | West Virginia 35, Tulane 17 | Box score |
| Sep 27, 1969 | Wyoming 27, Air Force 25 | Box score |