| Sep 20, 1969 | 13Alabama 17, Virginia Tech 13 | Box score |
| Sep 20, 1969 | Arizona State 48, 19Minnesota 26upset | Box score |
| Sep 20, 1969 | 2Arkansas 39, Oklahoma State 0 | Box score |
| Sep 20, 1969 | Army 31, New Mexico 14 | Box score |
| Sep 20, 1969 | 20Auburn 57, Wake Forest 0 | Box score |
| Sep 20, 1969 | BYU 22, Colorado State 20 | Box score |
| Sep 20, 1969 | Buffalo 17, Xavier 0 | Box score |
| Sep 20, 1969 | Cincinnati 26, William & Mary 18 | Box score |
| Sep 20, 1969 | Clemson 21, Virginia 14 | Box score |
| Sep 20, 1969 | Colorado 35, Tulsa 14 | Box score |
| Sep 20, 1969 | Florida 59, 7Houston 34upset | Box score |
| Sep 20, 1969 | Florida State 24, Wichita State 0 | Box score |
| Sep 20, 1969 | 8Georgia 35, Tulane 0 | Box score |
| Sep 20, 1969 | Georgia Tech 24, SMU 21 | Box score |
| Sep 20, 1969 | 14Indiana 58, Kentucky 30 | Box score |
| Sep 20, 1969 | Kansas State 45, Baylor 15 | Box score |
| Sep 20, 1969 | Long Beach State 32, California–Santa Barbara 16 | Box score |
| Sep 20, 1969 | LSU 35, Texas A&M 6 | Box score |
| Sep 20, 1969 | Miami (OH) 19, Dayton 9 | Box score |
| Sep 20, 1969 | Michigan 42, Vanderbilt 14 | Box score |
| Sep 20, 1969 | 12Michigan State 27, Washington 11 | Box score |
| Sep 20, 1969 | 9Ole Miss 28, Memphis 3 | Box score |
| Sep 20, 1969 | Mississippi State 17, Richmond 14 | Box score |
| Sep 20, 1969 | 10Missouri 19, Air Force 17 | Box score |
| Sep 20, 1969 | NC State 10, North Carolina 3 | Box score |
| Sep 20, 1969 | Northern Illinois 47, Idaho 30 | Box score |
| Sep 20, 1969 | 11Notre Dame 35, Northwestern 10 | Box score |
| Sep 20, 1969 | Ohio 35, Kent State 0 | Box score |
| Sep 20, 1969 | 6Oklahoma 48, Wisconsin 21 | Box score |
| Sep 20, 1969 | Oregon 28, Utah 17 | Box score |
| Sep 20, 1969 | Oregon State 42, Iowa 14 | Box score |
| Sep 20, 1969 | Pacific 21, Western Michigan 0 | Box score |
| Sep 20, 1969 | 3Penn State 45, Navy 22 | Box score |
| Sep 20, 1969 | 18Purdue 42, TCU 35 | Box score |
| Sep 20, 1969 | Rice 55, VMI 0 | Box score |
| Sep 20, 1969 | South Carolina 27, Duke 20 | Box score |
| Sep 20, 1969 | 5USC 31, Nebraska 21 | Box score |
| Sep 20, 1969 | 16Stanford 63, San José State 21 | Box score |
| Sep 20, 1969 | Syracuse 14, Iowa State 13 | Box score |
| Sep 20, 1969 | 4Texas 17, California 0 | Box score |
| Sep 20, 1969 | Texas Tech 38, Kansas 22 | Box score |
| Sep 20, 1969 | Toledo 45, Villanova 18 | Box score |
| Sep 20, 1969 | 17UCLA 42, Pittsburgh 8 | Box score |
| Sep 20, 1969 | Utah State 14, Bowling Green 6 | Box score |
| Sep 20, 1969 | Washington State 19, Illinois 18 | Box score |
| Sep 20, 1969 | West Virginia 31, Maryland 7 | Box score |
| Sep 20, 1969 | Wyoming 23, Arizona 7 | Box score |