| Oct 24, 1969 | Miami 14, TCU 9 | Box score |
| Oct 25, 1969 | 20Air Force 28, Colorado State 7 | Box score |
| Oct 25, 1969 | Alabama 38, Clemson 13 | Box score |
| Oct 25, 1969 | Arizona 52, New Mexico 28 | Box score |
| Oct 25, 1969 | 4Arkansas 52, Wichita State 14 | Box score |
| Oct 25, 1969 | Army 38, Boston College 7 | Box score |
| Oct 25, 1969 | Bowling Green 3, Miami (OH) 0 | Box score |
| Oct 25, 1969 | BYU 30, UTEP 7 | Box score |
| Oct 25, 1969 | California 17, Washington State 0 | Box score |
| Oct 25, 1969 | The Citadel 34, Davidson 28 | Box score |
| Oct 25, 1969 | Colgate 20, Brown 6 | Box score |
| Oct 25, 1969 | Colorado 31, 5Missouri 24upset | Box score |
| Oct 25, 1969 | Dartmouth 24, Harvard 10 | Box score |
| Oct 25, 1969 | NC State 25, Duke 25 | Box score |
| Oct 25, 1969 | 10Florida 41, Vanderbilt 20 | Box score |
| Oct 25, 1969 | Florida State 20, Mississippi State 17 | Box score |
| Oct 25, 1969 | Fresno State 24, Cal State Los Angeles 0 | Box score |
| Oct 25, 1969 | 13Georgia 30, Kentucky 0 | Box score |
| Oct 25, 1969 | Houston 25, 17Ole Miss 11upset | Box score |
| Oct 25, 1969 | Iowa 19, Michigan State 18 | Box score |
| Oct 25, 1969 | Iowa State 44, Kansas 20 | Box score |
| Oct 25, 1969 | 18Kansas State 59, 11Oklahoma 21upset | Box score |
| Oct 25, 1969 | 9LSU 21, 14Auburn 20 | Box score |
| Oct 25, 1969 | Memphis 40, Utah State 0 | Box score |
| Oct 25, 1969 | Michigan 35, Minnesota 9 | Box score |
| Oct 25, 1969 | Navy 10, Virginia 0 | Box score |
| Oct 25, 1969 | Nebraska 13, Oklahoma State 3 | Box score |
| Oct 25, 1969 | North Carolina 23, Wake Forest 3 | Box score |
| Oct 25, 1969 | North Texas 31, Louisville 13 | Box score |
| Oct 25, 1969 | 12Notre Dame 37, Tulane 0 | Box score |
| Oct 25, 1969 | 1Ohio State 41, Illinois 0 | Box score |
| Oct 25, 1969 | Oregon 22, Washington 7 | Box score |
| Oct 25, 1969 | 8Penn State 42, Ohio 3 | Box score |
| Oct 25, 1969 | Princeton 42, Pennsylvania 0 | Box score |
| Oct 25, 1969 | 15Purdue 45, Northwestern 20 | Box score |
| Oct 25, 1969 | Rutgers 21, Columbia 14 | Box score |
| Oct 25, 1969 | San Diego State 55, California–Santa Barbara 13 | Box score |
| Oct 25, 1969 | South Carolina 17, Maryland 0 | Box score |
| Oct 25, 1969 | 7USC 29, Georgia Tech 18 | Box score |
| Oct 25, 1969 | Southern Miss 31, Richmond 28 | Box score |
| Oct 25, 1969 | 2Texas 31, Rice 0 | Box score |
| Oct 25, 1969 | Texas A&M 24, Baylor 0 | Box score |
| Oct 25, 1969 | Texas Tech 27, SMU 24upset | Box score |
| Oct 25, 1969 | Toledo 43, Kent State 17 | Box score |
| Oct 25, 1969 | Tulsa 40, Cincinnati 24 | Box score |
| Oct 25, 1969 | 19Stanford 20, 6UCLA 20 | Box score |
| Oct 25, 1969 | Utah 7, Oregon State 3upset | Box score |
| Oct 25, 1969 | Villanova 35, Xavier 7 | Box score |
| Oct 25, 1969 | Virginia Tech 21, Buffalo 7 | Box score |
| Oct 25, 1969 | West Texas 17, New Mexico State 16 | Box score |
| Oct 25, 1969 | West Virginia 49, Pittsburgh 18 | Box score |
| Oct 25, 1969 | Western Michigan 48, Marshall 14 | Box score |
| Oct 25, 1969 | William & Mary 25, VMI 17 | Box score |
| Oct 25, 1969 | Wisconsin 36, Indiana 34upset | Box score |
| Oct 25, 1969 | 16Wyoming 16, San José State 7 | Box score |
| Oct 25, 1969 | Yale 17, Cornell 0 | Box score |