| Sep 23, 1960 | Denver 28, Washington State 26 | Box score |
| Sep 23, 1960 | Iowa State 44, Detroit Mercy 21 | Box score |
| Sep 23, 1960 | San José State 21, BYU 8 | Box score |
| Sep 23, 1960 | Southern Miss 27, Hardin Simmons 0 | Box score |
| Sep 23, 1960 | VMI 28, Buffalo 14 | Box score |
| Sep 24, 1960 | Air Force 32, Colorado State 8 | Box score |
| Sep 24, 1960 | Tulane 6, 5Alabama 6 | Box score |
| Sep 24, 1960 | Arizona State 14, West Texas 3 | Box score |
| Sep 24, 1960 | Arkansas 48, Tulsa 7 | Box score |
| Sep 24, 1960 | Army 20, Boston College 7 | Box score |
| Sep 24, 1960 | Baylor 26, Colorado 0 | Box score |
| Sep 24, 1960 | Cincinnati 27, Dayton 21 | Box score |
| Sep 24, 1960 | 9Clemson 28, Wake Forest 7 | Box score |
| Sep 24, 1960 | Colgate 28, Cornell 8upset | Box score |
| Sep 24, 1960 | Columbia 37, Brown 0 | Box score |
| Sep 24, 1960 | Duke 31, South Carolina 0 | Box score |
| Sep 24, 1960 | Florida 3, Florida State 0 | Box score |
| Sep 24, 1960 | George Washington 19, The Citadel 14 | Box score |
| Sep 24, 1960 | Georgia 18, Vanderbilt 7 | Box score |
| Sep 24, 1960 | 13Georgia Tech 16, Rice 13 | Box score |
| Sep 24, 1960 | Harvard 13, Holy Cross 6 | Box score |
| Sep 24, 1960 | Houston 14, Mississippi State 10 | Box score |
| Sep 24, 1960 | 4Illinois 17, Indiana 6 | Box score |
| Sep 24, 1960 | 19Iowa 22, 10Oregon State 12upset | Box score |
| Sep 24, 1960 | 7Kansas 41, Kansas State 0 | Box score |
| Sep 24, 1960 | Marquette 20, Pacific 0 | Box score |
| Sep 24, 1960 | Michigan 21, Oregon 0 | Box score |
| Sep 24, 1960 | 17Pittsburgh 7, 6Michigan State 7 | Box score |
| Sep 24, 1960 | Minnesota 26, 12Nebraska 14upset | Box score |
| Sep 24, 1960 | 1Ole Miss 21, Kentucky 6 | Box score |
| Sep 24, 1960 | 16Missouri 28, Oklahoma State 7 | Box score |
| Sep 24, 1960 | Navy 41, Villanova 7 | Box score |
| Sep 24, 1960 | NC State 3, North Carolina 0upset | Box score |
| Sep 24, 1960 | 14Northwestern 19, Oklahoma 3 | Box score |
| Sep 24, 1960 | Notre Dame 21, California 7 | Box score |
| Sep 24, 1960 | 20Ohio State 24, SMU 0 | Box score |
| Sep 24, 1960 | Rutgers 13, Princeton 8 | Box score |
| Sep 24, 1960 | 2Syracuse 35, Boston University 7 | Box score |
| Sep 24, 1960 | Tennessee 10, Auburn 3upset | Box score |
| Sep 24, 1960 | 15Texas 34, Maryland 0 | Box score |
| Sep 24, 1960 | TCU 7, USC 6 | Box score |
| Sep 24, 1960 | Texas A&M 14, Texas Tech 14 | Box score |
| Sep 24, 1960 | North Texas 16, UTEP 16 | Box score |
| Sep 24, 1960 | Purdue 27, 8UCLA 27 | Box score |
| Sep 24, 1960 | Utah 13, Arizona 3 | Box score |
| Sep 24, 1960 | Utah State 14, Montana 12 | Box score |
| Sep 24, 1960 | Virginia Tech 15, West Virginia 0 | Box score |
| Sep 24, 1960 | 3Washington 41, Idaho 12 | Box score |
| Sep 24, 1960 | Wichita State 20, Xavier 13 | Box score |
| Sep 24, 1960 | William & Mary 41, Virginia 21 | Box score |
| Sep 24, 1960 | Wisconsin 24, Stanford 7 | Box score |
| Sep 24, 1960 | Wyoming 13, New Mexico 3 | Box score |