| Sep 26, 1941 | Auburn 13, Samford 0 | Box score |
| Sep 26, 1941 | Duquesne 33, Niagara 0 | Box score |
| Sep 26, 1941 | Furman 40, Wofford 19 | Box score |
| Sep 26, 1941 | Georgetown 16, Ole Miss 6 | Box score |
| Sep 26, 1941 | Montana 20, BYU 7upset | Box score |
| Sep 26, 1941 | New Mexico 12, Northern Arizona 6 | Box score |
| Sep 26, 1941 | New Mexico State 7, Western New Mexico 6 | Box score |
| Sep 26, 1941 | Saint Louis 13, Missouri–Rolla 7 | Box score |
| Sep 26, 1941 | San José State 30, Utah State 0 | Box score |
| Sep 26, 1941 | Syracuse 39, Clarkson 0 | Box score |
| Sep 26, 1941 | Texas A&M–Kingsville 35, Arizona State 7upset | Box score |
| Sep 26, 1941 | Wyoming 19, Northern Colorado 6 | Box score |
| Sep 27, 1941 | Alabama 47, Louisiana 6 | Box score |
| Sep 27, 1941 | Arkansas 56, East Central 0 | Box score |
| Sep 27, 1941 | Brown 20, Wesleyan (CT) 6 | Box score |
| Sep 27, 1941 | The Citadel 45, High Point 0 | Box score |
| Sep 27, 1941 | Clemson 36, VMI 7 | Box score |
| Sep 27, 1941 | Colgate 66, St. Lawrence 0 | Box score |
| Sep 27, 1941 | Colorado State 21, Colorado School of Mines 6 | Box score |
| Sep 27, 1941 | Dartmouth 35, Norwich 0 | Box score |
| Sep 27, 1941 | Kansas State 0, Fort Hays 0 | Box score |
| Sep 27, 1941 | George Washington 25, Mount St. Mary’s 0 | Box score |
| Sep 27, 1941 | Georgia 81, Mercer 0 | Box score |
| Sep 27, 1941 | UTEP 0, Louisiana Tech 0 | Box score |
| Sep 27, 1941 | Loyola Marymount 20, Redlands 0 | Box score |
| Sep 27, 1941 | Manhattan 20, St. Bonaventure 12 | Box score |
| Sep 27, 1941 | Maryland 18, Hampden Sydney 0 | Box score |
| Sep 27, 1941 | New York University 25, Pennsylvania Military 7 | Box score |
| Sep 27, 1941 | Pacific Lutheran 26, Gonzaga 13upset | Box score |
| Sep 27, 1941 | Richmond 26, Randolph Macon 0 | Box score |
| Sep 27, 1941 | SMU 54, North Texas 0 | Box score |
| Sep 27, 1941 | Texas A&M 54, Sam Houston 0 | Box score |
| Sep 27, 1941 | Utah 26, Idaho 7 | Box score |
| Sep 27, 1941 | Virginia 25, Lafayette 0 | Box score |
| Sep 27, 1941 | West Texas 7, Fresno State 6 | Box score |
| Sep 27, 1941 | West Virginia 13, Waynesburg 7 | Box score |